Research

The overarching goal of the Spinelli lab is to understand how cells sense and adapt to metabolic stress. We aim to uncover mechanisms underlying metabolic flexibility in healthy mammals, and determine how these adaptations are dysfunctional in the context of diseases like cancer, obesity, mitochondrial myopathies, and ischemia. We employ techniques in biochemistry, chemical biology, and physiology, and often develop new molecular tools to facilitate our research.

 

Technology: The Spinelli Lab is equipped with high resolution mass spectrometry, which we use for in-house metabolite profiling. Spinelli Lab trainees are highly encouraged to learn how to maintain and operate this instrument.