Publications
Swaminathan A, Hwang Y, Winward A, Socolovsky M. Identification and Isolation of Burst-Forming Unit and Colony-Forming Unit Erythroid Progenitors from Mouse Tissue by Flow Cytometry. J Vis Exp. 2022 Nov 4;(189). doi: 10.3791/64373. PubMed PMID: 36408979 [View in: PubMed]
Socolovsky, M. “Progress in Hematology” invited review: ‘The role of specialized cell cycles during erythroid lineage development: insights from single‑cell RNA sequencing’. International Journal of Hematology https://doi.org/10.1007/s12185-022-03406-9 (2022)
Vogel C, Balázsi G, Löwer A, Jiang C, Schmid AK, Sommer M, Yang L, Münch C, Wang A, Israni-Winger K, Mühlhaus T, Des Marais DL, Oster H.; Socolovsky, M. ‘What differentiates a stress response from responsiveness in general?’ Invited opinion column, Cell Systems, 13 (3), 195-200. PMID: 35298910 (2022)
Daniel Hidalgo, Jacob Bejder, Ramona Pop, Kyle Gellatly, Yung Hwag, S. Maxwell Scalf, Anna E. Eastman, Jane-Jane-Chen, L.Julie Zhu, Jules AAC Heugerger, Shangqin Guo, Mark J. Koury, Nikolai Baastrup Nordsborg, Merav Socolovsky. EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis. Nature Communications 2021 Dec 17; 12(1):7334. PMID: 34921133
The shifting shape and functional specializations of the cell cycle during lineage development. WIREs Mech Dis. 2021 Mar;13(2):e1504. doi: 10.1002/wsbm.1504. Epub 2020 Sep 11. Review. PubMed PMID: 32916032; PubMed Central PMCID: PMC9004340.
A. Marieke Oudelaar, Robert A. Beagrie, Matthew Gosden, Sara de Ornellas, Emily Georgiades, Jon Kerry, Daniel Hidalgo, Joana Carrelha, Arun Shivalingam, Afaf H. El-Sagheer, Jelena M. Telenius, Tom Brown, Veronica J. Buckle, Merav Socolovsky, Douglas R. Higgs and Jim R. Hughes. Dynamics of the 4D genome during in vivo mouse erythroid lineage specification and differentiation. Nature Communications 2020 Jun 1;11(1):2722. doi: 10.1038/s41467-020-16598-7. PubMed PMID: 32483172; PubMed Central PMCID: PMC7264236 [View in: PubMed]
Pawaria S, Nündel K, Gao KM, Moses S, Busto P, Holt K, Sharma RB, Brehm MA, Gravallese EM, Socolovsky M, Christ A, Marshak-Rothstein A. Role of Interferon-g-Producing Th1 Cells in a Murine Model of Type I Interferon-Independent Autoinflammation Resulting from DNase II Deficiency. Arthritis Rheumatol. 2019; doi: 10.1002/art.41090. PubMed PMID: 31464028 [View in: PubMed]
Betsabeh Khoramian Tusi, Samuel L. Wolock, Caleb Weinreb, Yung Hwang, Daniel Hidalgo, Rapolas Zilionis, Ari Waisman, Jun R. Huh, Allon M. Klein and Merav Socolovsky. Population Snapshots Predict Early Hematopoietic and Erythroid Hierarchies. Nature. 2018 Mar 1;555(7694):54-60. doi: 10.1038/nature25741. Epub 2018 Feb 21.[View in: Nature.com]
Betsabeh Khoramian Tusi and Merav Socolovsky. High Throughput Single-Cell Fate Potential Assay of Murine Hematopoietic Progenitors in Vitro. Experimental Hematology, in press. Exp Hematol. 2018 Apr;60:21-29.e3. doi: 10.1016/j.exphem.2018.01.005. Epub 2018 Jan 31. [View in: Experimental Hematology]
Yung Hwang, Melinda Futran, Daniel Hidalgo, Ramona Pop, Divya Ramalingam Iyer, Ralph Scully, Nicholas Rhind and Merav Socolovsky. Global Increase in Replication Fork Speed During a p57KIP2-Regulated Erythroid Cell Fate Switch. Science Advances, 26 May 2017: Vol. 3, no. 5, e1700298 DOI: 10.1126/sciadv.1700298 [View in: Science Advances]
Koulnis M, Porpiglia E, Hidalgo D, Socolovsky M. Erythropoiesis: from molecular pathways to system properties. Adv Exp Med Biol. 2014; 844:37-58. [View in: PubMed]
Socolovsky M. Exploring the erythroblastic island. Nat Med. 2013 Apr; 19(4):399-401. [View in: PubMed]
Porpiglia E, Hidalgo D, Koulnis M, Tzafriri AR, Socolovsky M. Stat5 Signaling Specifies Basal versus Stress Erythropoietic Responses through Distinct Binary and Graded Dynamic Modalities. PLoS Biol. 2012 Aug; 10(8):e1001383. [View in: PubMed]
Koulnis M, Porpiglia E, Porpiglia PA, Liu Y, Hallstrom K, Hidalgo D, Socolovsky M. Contrasting dynamic responses in vivo of the BCL-XL and BIM erythropoietic survival pathways. Blood. 2011 Nov 15. [View in: PubMed]
Shearstone JR, Pop R, Bock C, Boyle P, Meissner A, Socolovsky M. Global DNA demethylation during mouse erythropoiesis in vivo. Science. 2011 Nov 11; 334(6057):799-802. [View in: PubMed]
Koulnis M, Pop R, Porpiglia E, Shearstone JR, Hidalgo D, Socolovsky M. Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay. J Vis Exp. 2011; (54). [View in: PubMed]
Koulnis M, Liu Y, Hallstrom K, Socolovsky M. Negative autoregulation by fas stabilizes adult erythropoiesis and accelerates its stress response. PLoS One. 2011; 6(7):e21192. [View in: PubMed]
Kang BH, Xia F, Pop R, Dohi T, Socolovsky M, Altieri DC. Developmental Control of Apoptosis by the Immunophilin Aryl Hydrocarbon Receptor-interacting Protein (AIP) Involves Mitochondrial Import of the Survivin Protein. J Biol Chem. 2011 May 13; 286(19):16758-67. [View in: PubMed]
Pop R, Shearstone JR, Shen Q, Liu Y, Hallstrom K, Koulnis M, Gribnau J, Socolovsky M. A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression. PLoS Biol. 2010; 8(9). [View in: PLoS Biology]
Socolovsky M, Murrell M, Liu Y, Pop R, Porpiglia E, Levchenko A. Negative autoregulation by FAS mediates robust fetal erythropoiesis. PLoS Biol. 2007 Oct; 5(10):e252. [View in: PubMed]
Socolovsky M. Molecular insights into stress erythropoiesis. Curr Opin Hematol. 2007 May; 14(3):215-24. [View in: PubMed]
Liu Y, Pop R, Sadegh C, Brugnara C, Haase VH, Socolovsky M. Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood. 2006 Jul 1; 108(1):123-33. [View in: PubMed]
Silberstein L, Sanchez MJ, Socolovsky M, Liu Y, Hoffman G, Kinston S, Piltz S, Bowen M, Gambardella L, Green AR, Gottgens B. Transgenic analysis of the stem cell leukemia +19 stem cell enhancer in adult and embryonic hematopoietic and endothelial cells. Stem Cells. 2005 Oct; 23(9):1378-88. [View in: PubMed]
Zhang J, Socolovsky M, Gross AW, Lodish HF. Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system. Blood. 2003 Dec 1; 102(12):3938-46. [View in: PubMed]
Takahashi C, Bronson RT, Socolovsky M, Contreras B, Lee KY, Jacks T, Noda M, Kucherlapati R, Ewen ME. Rb and N-ras function together to control differentiation in the mouse. Mol Cell Biol. 2003 Aug; 23(15):5256-68. [View in: PubMed]
Brisken C, Socolovsky M, Lodish HF, Weinberg R. The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14241-5. [View in: PubMed]
Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF. Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood. 2001 Dec 1; 98(12):3261-73. [View in: PubMed]
Constantinescu SN, Keren T, Socolovsky M, Nam H, Henis YI, Lodish HF. Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4379-84. [View in: PubMed]
Scully R, Ganesan S, Vlasakova K, Chen J, Socolovsky M, Livingston DM. Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell. 1999 Dec; 4(6):1093-9. [View in: PubMed]
Socolovsky M, Fallon AE, Wang S, Brugnara C, Lodish HF. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell. 1999 Jul 23; 98(2):181-91. [View in: PubMed]
Socolovsky M, Fallon AE, Lodish HF. The prolactin receptor rescues EpoR-/- erythroid progenitors and replaces EpoR in a synergistic interaction with c-kit. Blood. 1998 Sep 1; 92(5):1491-6. [View in: PubMed]
Socolovsky M, Lodish HF, Daley GQ. Control of hematopoietic differentiation: lack of specificity in signaling by cytokine receptors. Proc Natl Acad Sci U S A. 1998 Jun 9; 95(12):6573-5. [View in: PubMed]
Bergelson S, Klingmüller U, Socolovsky M, Hsiao JG, Lodish HF. Tyrosine residues within the intracellular domain of the erythropoietin receptor mediate activation of AP-1 transcription factors. J Biol Chem. 1998 Jan 23; 273(4):2396-401. [View in: PubMed]
Socolovsky M, Constantinescu SN, Bergelson S, Sirotkin A, Lodish HF. Cytokines in hematopoiesis: specificity and redundancy in receptor function. Adv Protein Chem. 1998; 52:141-98. [View in: PubMed]
Socolovsky M, Dusanter-Fourt I, Lodish HF. The prolactin receptor and severely truncated erythropoietin receptors support differentiation of erythroid progenitors. J Biol Chem. 1997 May 30; 272(22):14009-12. [View in: PubMed]
Watowich SS, Wu H, Socolovsky M, Klingmuller U, Constantinescu SN, Lodish HF. Cytokine receptor signal transduction and the control of hematopoietic cell development. Annu Rev Cell Dev Biol. 1996; 12:91-128. [View in: PubMed]