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Kara Smith, MD, publication report from PubMed

Total: 20 results

  • SARS-CoV-2 Illumina GeNome Assembly Line (SIGNAL), a Snakemate workflow for rapid and bulk analysis of Illumina sequencing of SARS-CoV-2 genomes

    Friday, December 20, 2024
    Author(s): Jalees A Nasir,Finlay Maguire,Kendrick M Smith,Emily M Panousis,Sheridan J C Baker,Patryk Aftanas,Amogelang R Raphenya,Brian P Alcock,Hassaan Maan,Natalie C Knox,Arinjay Banerjee,Karen Mossman,Bo Wang,Jared T Simpson,Robert A Kozak,Samira Mubareka,Andrew G McArthur
    Source: NAR genomics and bioinformatics
    The incorporation of sequencing technologies in frontline and public health healthcare settings was vital in developing virus surveillance programs during the Coronavirus Disease 2019 (COVID-19) pandemic caused by transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, increased data acquisition poses challenges for both rapid and accurate analyses. To overcome these hurdles, we developed the SARS-CoV-2 Illumina GeNome Assembly Line (SIGNAL) for quick bulk...

  • Reconstructing decision-making dynamics during public health crises by applying data science to public records

    Wednesday, December 18, 2024
    Author(s): Peter Nadel,Kevin M Smith
    Source: Journal of public health policy
    Public health policies can dramatically shape government responses to emerging public health crises. In cases where a response is inadequate, it's natural to seek improvements to these policies to achieve better results in future crises. However, while policies and outcomes are usually visible, the complex dynamics that link them are seldom obvious. Obscure social network structures, power and information asymmetries, and political agendas all influence the translation of policy to action or...

  • Stochastic Models of Zoonotic Avian Influenza with Multiple Hosts, Environmental Transmission, and Migration in the Natural Reservoir

    Sunday, December 15, 2024
    Author(s): Rowan L Hassman,Iona M H McCabe,Kaia M Smith,Linda J S Allen
    Source: Bulletin of mathematical biology
    Avian influenza virus type A causes an infectious disease that circulates among wild bird populations and regularly spills over into domesticated animals, such as poultry and swine. As the virus replicates in these intermediate hosts, mutations occur, increasing the likelihood of emergence of a new variant with greater transmission to humans and a potential threat to public health. Prior models for spread of avian influenza have included some combinations of the following components: multi-host...

  • Dietary prevention of antibiotic-induced dysbiosis and mortality upon aging in mice

    Tuesday, December 10, 2024
    Author(s): Kelsey M Smith,Sarah G Francisco,Ying Zhu,Tanya LeRoith,Meredith L Davis,Jimmy W Crott,Kathryn Barger,Andrew S Greenberg,Donald E Smith,Allen Taylor,Laxmi Yeruva,Sheldon Rowan
    Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    Oral antibiotic use is both widespread and frequent in older adults and has been linked to dysbiosis of the gut microbiota, enteric infection, and chronic diseases. Diet and nutrients, particularly prebiotics, may modify the susceptibility of the gut microbiome to antibiotic-induced dysbiosis. We fed 12-month-old mice a high glycemic (HG) or low glycemic (LG) diet with or without antibiotics (ampicillin and neomycin) for an additional 11 months. The glycemic index was modulated by the ratio of...

  • Advance Care Planning, End-of-Life Preferences, and Burdensome Care: A Pragmatic Cluster Randomized Clinical Trial

    Monday, December 02, 2024
    Author(s): Jennifer L Wolff,Danny Scerpella,Erin R Giovannetti,David L Roth,Valecia Hanna,Naaz Hussain,Jessica L Colburn,Martha Abshire Saylor,Cynthia M Boyd,Valerie Cotter,Maura McGuire,Christine Rawlinson,Danetta H Sloan,Thomas M Richards,Kathryn Walker,Kelly M Smith,Sydney M Dy,SHARING Choices Investigators
    Source: JAMA internal medicine
    CONCLUSIONS AND RELEVANCE: In this pragmatic cluster randomized clinical trial, the SHARING Choices intervention increased new documentation of end-of-life preferences but also increased potentially burdensome care at end of life. Mixed findings underscore the importance of comprehensive support for those with serious illness and prioritizing patient-relevant outcomes in ACP interventional research.

  • Using Z Codes to Document Social Risk Factors in the Electronic Health Record: A Scoping Review

    Thursday, November 21, 2024
    Author(s): Kelley M Baker,Mary A Hill,Debora G Goldberg,Panagiota Kitsantas,Kristen E Miller,Kelly M Smith,Alicia Hong
    Source: Medical care
    INTRODUCTION: Individual-level social risk factors have a significant impact on health. Social risks can be documented in the electronic health record using ICD-10 diagnosis codes (the "Z codes"). This study aims to summarize the literature on using Z codes to document social risks.

  • Low Success Rate of Closed Reductions when Treating Dislocations after Reverse Shoulder Arthroplasty: A Study by the ASES Complications of RSA Multicenter Research Group

    Friday, November 15, 2024
    Author(s): ASES Complications of RSA Research Group,Richard Puzzitiello,Evan A Glass,Adam R Bowler,Daniel P Swanson,Michael Moverman,Ryan Lohre,Kuhan A Mahendraraj,Miranda McDonald-Stahl,Declan R Diestel,Kiet Le,Warren R Dunn,Dylan J Cannon,Lisa Gm Friedman,Jaina A Gaudette,John Green,Lauren Grobaty,Michael Gutman,Jacquelyn Kakalecik,Michael A Kloby,Elliot N Konrade,Margaret C Knack,Amy Loveland,Joshua I Mathew,Luke Myhre,Jacob Nyfeler,Doug E Parsell,Marissa Pazik,Teja S Polisetty,Padmavathi Ponnuru,Karch M Smith,Katherine A Sprengel,Ocean Thakar,Lacie Turnbull,Alayna Vaughan,John C Wheelwright,Joseph Abboud,April Armstrong,Luke Austin,Tyler Brolin,Vahid Entezari,Grant E Garrigues,Brian Grawe,Lawrence V Gulotta,Rhett Hobgood,John G Horneff,Jason E Hsu,Joseph Iannotti,Michael Khazzam,Joseph J King,Jacob M Kirsch,Jonathan C Levy,Anand Murthi,Surena Namdari,Gregory P Nicholson,Randall J Otto,Eric T Ricchetti,Robert Tashjian,Thomas Throckmorton,Thomas Wright,Andrew Jawa
    Source: Journal of shoulder and elbow surgery
    CONCLUSION: In this large multicenter series of postoperative dislocations following RSA, a closed reduction was initially attempted in the majority of patients, but only about one-third were successful and required no further intervention. Unsuccessful closed reductions were associated with higher patient BMI. Revision surgery for dislocations was complicated by a high rate of recurrent dislocations and re-revision surgery.

  • A rare case report of omental synovial sarcoma complicated hemoperitoneum and literature review

    Friday, November 15, 2024
    Author(s): Nguyen Van Manh,Doan Thanh Huy,Vo Thi Tram Anh,Nguyen Huu Thanh,Kelly Marie Smith
    Source: World journal of surgical oncology
    CONCLUSIONS: Primary omental synovial sarcoma is uncommon and presents with nonspecific clinical symptoms, often leading to potential misdiagnosis with other conditions before surgery. They occur predominantly in females, mainly middle-aged, with a large mass size before presentation. Due to the high recurrence and mortality rate, it needs to be recognized at the early stage.

  • A statistical mechanics investigation of unfolded protein response across organisms

    Tuesday, November 12, 2024
    Author(s): Nicole Luchetti,Keith M Smith,Margherita A G Matarrese,Alessandro Loppini,Simonetta Filippi,Letizia Chiodo
    Source: Scientific reports
    Living systems rely on coordinated molecular interactions, especially those related to gene expression and protein activity. The Unfolded Protein Response is a crucial mechanism in eukaryotic cells, activated when unfolded proteins exceed a critical threshold. It maintains cell homeostasis by enhancing protein folding, initiating quality control, and activating degradation pathways when damage is irreversible. This response functions as a dynamic signaling network, with proteins as nodes and...

  • Tailored management of cavernous malformations in women: considerations and strategies-a review

    Friday, November 08, 2024
    Author(s): Delal Bektas,Giuseppe Lanzino,Kelsey M Smith,Kelly D Flemming
    Source: Frontiers in neurology
    PURPOSE OF REVIEW: Cavernous malformations (CM) are vascular lesions in the brain and spinal cord, characterized by clusters of endothelial-lined caverns lacking proper tight junctions. These malformations may be discovered incidentally or present with symptoms such as headaches, focal neurologic deficits, or seizures, with or without hemorrhage. This review focuses on non-surgical management considerations important for women with CM, who face challenges related to pregnancy, exogenous hormone...

  • CHD2-related epilepsy with eyelid myoclonia: Report of three cases

    Wednesday, November 06, 2024
    Author(s): Hannah Padilla,Filippo Pinto E Vairo,Elaine C Wirrell,Lily C Wong-Kisiel,Anthony L Fine,Brendan C Lanpher,Kelsey M Smith
    Source: Epileptic disorders : international epilepsy journal with videotape
    The aim of this study is to report three cases of epilepsy with eyelid myoclonia (EEM) with CHD2 pathogenic variants. A database of 134 patients with EEM evaluated at Mayo Clinic sites was searched to identify patients with CHD2 variants. The medical records of those identified were reviewed to describe their presentation, treatment, and clinical course. Three patients (2 males, 1 female) with EEM were found to harbor de novo CHD2 pathogenic variants (c.2636CT p.(Ala879Val), c.3734delA p....

  • Racism and Redlining in the History of Psychiatric Policy and Practice in Atlanta: Implications for Nursing

    Monday, November 04, 2024
    Author(s): Avi Wofsy,Kylie M Smith
    Source: Policy, politics & nursing practice
    Recently, the Georgia state House of Representatives passed House Bill 1013, also called The Mental Health Parity Act. The bill sought to address access to and insurance coverage for mental health services, first identified in a report in 2020. The budget for mental health services was reduced by $8 m in 2020, despite an all-time high demand due to the beginning of the Covid-19 pandemic. There is an increasing inability to secure mental health care in the state. Georgia is ranked 37^(th) in the...

  • Lateral lamina V projection neuron axon collaterals connect sensory processing across the dorsal horn of the mouse spinal cord

    Saturday, November 02, 2024
    Author(s): Tyler J Browne,Kelly M Smith,Mark A Gradwell,Christopher V Dayas,Robert J Callister,David I Hughes,Brett A Graham
    Source: Scientific reports
    Spinal projection neurons (PNs) are defined by long axons that travel from their origin in the spinal cord to the brain where they relay sensory information from the body. The existence and function of a substantial axon collateral network, also arising from PNs and remaining within the spinal cord, is less well appreciated. Here we use a retrograde viral transduction strategy to characterise a novel subpopulation of deep dorsal horn spinoparabrachial neurons. Brainbow assisted analysis...

  • Kappa opioids inhibit spinal output neurons to suppress itch

    Wednesday, September 25, 2024
    Author(s): Tayler D Sheahan,Charles A Warwick,Abby Y Cui,David A A Baranger,Vijay J Perry,Kelly M Smith,Allison P Manalo,Eileen K Nguyen,H Richard Koerber,Sarah E Ross
    Source: Science advances
    Itch is a protective sensation that drives scratching. Although specific cell types have been proposed to underlie itch, the neural basis for itch remains unclear. Here, we used two-photon Ca^(2+) imaging of the dorsal horn to visualize neuronal populations that are activated by itch-inducing agents. We identify a convergent population of spinal interneurons recruited by diverse itch-causing stimuli that represents a subset of neurons that express the gastrin-releasing peptide receptor (GRPR)....

  • A Clinic for the People: Toward an Antiracist Psychiatry at the Tuskegee Institute 1947-1965

    Monday, September 23, 2024
    Author(s): Kylie M Smith
    Source: Bulletin of the history of medicine
    From 1947 until 1963, a small group of psychiatrists from the Tuskegee Veterans Administration Hospital ran a Mental Hygiene Clinic designed to provide outpatient care and education to the Black residents of Macon County, Alabama. In an analysis of the clinic and the work of its Director, Dr. Prince Barker, we see the ways that Black psychiatrists tried to develop an antiracist approach to psychiatry and to develop their own autonomy in segregated Alabama. But there were limitations to this...

  • Using Patient Experience Surveys to Identify Potential Diagnostic Safety Breakdowns: A Mixed Methods Study

    Monday, September 16, 2024
    Author(s): Kelley M Baker,Mark Brahier,Mara Penne,Mary A Hill,Siara Davis,William J Gallagher,Kristen E Miller,Kelly M Smith
    Source: Journal of patient safety
    CONCLUSIONS: Patient feedback in routinely collected patient experience surveys is a valuable and actionable information source on diagnostic breakdowns in the ambulatory setting. The more easily monitored structured survey data provide a screening method to identify encounters that may have included a patient-perceived diagnostic breakdown and therefore require further examination.

  • Leverage pre-requisite courses to teach bachelor of science in nursing students about social determinants of health

    Thursday, September 12, 2024
    Author(s): Lisa Muirhead,Rose Hayes,Melinda Higgins,Kristy Kiel Martyn,Kylie M Smith,Linda McCauley
    Source: Journal of professional nursing : official journal of the American Association of Colleges of Nursing
    BACKGROUND: Nurses have frequent opportunities to address social determinants of health (SDOH) in practice. However, many nurses graduate without completing coursework in SDOH, and there remain barriers to incorporating SDOH content into nursing curricula.

  • Variability in Vowel Space in Parkinson's Disease: Associations With Cognitive and Motor Impairment

    Wednesday, September 11, 2024
    Author(s): Ginige S DeSilva,Prashasti Upadhyay,Michelle Manxhari,Daksha Gopal,Kara M Smith
    Source: Journal of speech, language, and hearing research : JSLHR
    CONCLUSIONS: Variability in vowel space is impacted by cognitive impairment and speech task in PwP. These findings are relevant to the further development of speech markers in PwP and other neurogenerative diseases that impact both cognitive and motor functions.

  • "What Else Could It Be?" A Scoping Review of Questions for Patients to Ask Throughout the Diagnostic Process

    Wednesday, September 11, 2024
    Author(s): Mary A Hill,Tess Coppinger,Kimia Sedig,William J Gallagher,Kelley M Baker,Helen Haskell,Kristen E Miller,Kelly M Smith
    Source: Journal of patient safety
    CONCLUSIONS: Despite recommendations for patients to ask questions, most question prompt lists focus on later stages of the diagnostic process such as communication of the diagnosis, treatment, and outcomes. Further research is needed to identify and prioritize diagnostic-related questions from the patient perspective and to develop simple, usable guidance on question-asking to improve patient safety across the diagnostic continuum.

  • Reported impact and protective factors of the care partner role during persistent critical illness: a content analysis

    Friday, September 06, 2024
    Author(s): Laura Istanboulian,Anthony J Gilding,Lorrie Hamilton,Tasneem Master,Sarah Bingler,Karen Soldatic,Kelly M Smith
    Source: BMC nursing
    CONCLUSIONS: This study identified physical, socio-emotional, and social stress related impacts of care provision on care partners of patients with persistent critical illness during hospitalization. Additionally, this study identified protective factors initiated by care partners to mitigate the reported stresses of the role, as well as protective features of a care partner program. The results provide a better understanding supportive features of care partner programs that are specific to the...