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Former Student Dissertations

 
Jacqueto Zephyr 
Robust Drug Design Strategies and Discovery Targeting Viral Proteases 
 08/2021
 
Anne Jecrois  
CtBPs and IRF3 at the Intersection of Transcriptional Regulation by Macromolecular Complexes 
 05/2021
 
Heather Loring 
Insights into the Role of SARM1 in Pathological Neuron Death
01/2021
 
Florian Leidner
Molecular Mechanisms of Drug Resistance in HIV-1 Protease
12/2020
 
Shurong Hou                      
Structural Mechanism of Substrate Specificity In Human Cytidine Deaminase Family APOBEC3s 
 04/2020
 
Gordon Lockbaum
Molecular Mechanisms of Resistance and Structure-Based Drug Design in Homodimeric Viral Proteases
04/2020
 

Ashley N. Matthew
Targeting Drug Resistance in HCV NS3/4A Protease: Mechanisms and Inhibitor Design Strategies
04/2018

Tania V. Silvas
Investigating the Structural Basis for Human Disease: APOBEC3A and Profilin
01/2018

Debra A. Ragland
The Structural Basis for the Interpendence of Drug Resistance in the HIV-1 Protease
12/2016

Kuan-Hing Lin
Viral Protease as Drug Targets and the Mechanisms of Drug Resistance: A Dissertation
09/2016

Kristina L. Prachanronarong
Understanding Drug Resistance and Antibody Neutralization Escape in Antivirals: A Dissertation
04/2016

Djade I. Soumana
Hepatitis C Virus: Structurel Insights into Protease Inhibitor Efficacy and Drug Resistance: A Dissertation
12/2015

Markus-Frederik Bohn
Establishing APOBEC3F as a Structural Target for Novel Antiretroviral Strategies
03/2014

Brendan Hilbert
Structure-Based Targeting of Transcriptional Regulatory Complexes Implicated in Human Disease
07/2013

Ayşegül Özen
Structure and Dynamics of Viral Substrate Recognition and Drug Resistance: A Dissertation
05/2013

Cihan Aydin 
Hepatitis C Virus Non-Structural Protein 3/4A: A Tale of Two Domains: A Dissertation 
08/2011

Seema Mittal 
Role of Protein Flexibility in Function, Resistance Pathways and Substrate Recognition Specificity in HIV-1 Protease: A Dissertation 
08/2011

Shivender Shandilya 
Structural Studies of the Anti-HIV Human Protein APOBEC3G Catalytic Domain: A Dissertation 
08/2011

Keith P. Romano 
Mechanisms of Substrate Recognition by HCV NS3/4A Protease Provide Insights Into Drug Resistance: A Dissertation 
05/2011

Rajintha M. Bandaranayake 
Exploring Molecular Mechanisms of Drug Resistance in HIV-1 Protease through Biochemical and Biophysical Studies: A Dissertation
05/2010

Michael W. Straza 
A Tale of Two ARFs: Tumor Suppressor and Anti-viral Functions of p14ARF: A Dissertation 
05/2010

Yufeng Cai 
Energetic and Dynamic Analysis of Inhibitor Binding to Drug-Resistant HIV-1 Proteases: A Dissertation 
11/2009 

Madhavi Kolli 
Co-evolution of HIV-1 Protease and its Substrates: A Dissertation 
11/2009 

Jared R. Auclair 
Probing the Structural Topology of HIV-1 Virion Infectivity Factor (VIF): A Dissertation 
12/2007 

Jennifer E. Murzycki 
Probing Protein Dynamics Through Mutational and Computational Studies of HIV-1 Protease: A Dissertation 
09/2006