Research Focus - CRISPR-Cas Biology and Genome Engineering Applications
Biology and mechanism of RNA-based gene regulation
CRISPR interference
RNA-directed genome editing and gene control
Representative Publications
Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo. Ibraheim R, Tai PWL, Mir A, Javeed N, Wang J, Rodríguez TC, Namkung S, Nelson S, Khokhar ES, Mintzer E, Maitland S, Chen Z, Cao Y, Tsagkaraki E, Wolfe SA, Wang D, Pai AA, Xue W, Gao G, Sontheimer EJ.Nat Commun. 2021 Nov 1;12(1):6267. doi: 10.1038/s41467-021-26518-y.PMID: 34725353Read Publication
UMass Chan BRIDGE Fund invests nearly $2M in 13 faculty projects
The BRIDGE Fund supports critical research milestones for inventions and discoveries that have high potential to change the course of disease and continues to grow, increasing from approximately $1 million per year in 2019 to $3 million in 2024.
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, Graduate School of Biomedical Sciences, School of Medicine, Dermatology, Medicine, Cancer Center, Faculty, Award, Research, Craig Ceol, Dohoon Kim, Paul R. Thompson, Sontheimer Lab, Harris Lab, John Harris, Molecular, Cell and Cancer Biology, RNA Therapeutics Institute, Microbiology and Physiological Systems, Program in Molecular Medicine, Celia Schiffer, Schiffer Lab, Latest News, Andrei Korostelev, Biochemistry and Molecular Biotechnology, Erik Sontheimer, BRIDGE, Top Stories, Fiachra Humphries,
Mar 4, 2024
UMass Chan scientists receive $2.3 million from Rett Syndrome Research Trust for new research
Rett syndrome is a rare geneticneurological disorder that occurs primarily in girls, eventually robbing them of the ability to speak, walk or use their hands, among other devastating effects.
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, Watts Lab, Faculty, Jonathan K. Watts, Scot A. Wolfe, Wolfe Lab, Sontheimer Lab, Molecular, Cell and Cancer Biology, RNA Therapeutics Institute, Latest News, Erik Sontheimer, Top Stories,
