Research Focus - Medicinal Chemistry of Therapeutic RNAs
Development of novel oligonucleotide-based therapeutics
Drug development
Mechanism of small RNA trafficking
RNA medicinal chemistry and delivery
Representative Publications
An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis. Yenilmez B, Wetoska N, Kelly M, Echeverria D, Min K, Lifshitz L, Alterman JF, Hassler MR, Hildebrand S, DiMarzio C, McHugh N, Vangjeli L, Sousa J, Pan M, Han X, Brehm MA, Khvorova A, Czech MP.Mol Ther. 2021 Nov 10:S1525-0016(21)00578-5. doi: 10.1016/j.ymthe.2021.11.007. Online ahead of print.PMID: 34774753Read Publication
Novel siRNA backbone developed at UMass Chan enhances stability, durability of potentially therapeutic platform
A biochemical breakthrough using simple carbon atoms by Ken Yamada, PhD, and Anastasia Khvorova, PhD, has dramatically improved the stability and efficacy of a potential oligonucleotide therapeutic platform in mice.
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, Graduate School of Biomedical Sciences, School of Medicine, Faculty, Research, Anastasia Khvorova, RNA Therapeutics Institute, Latest News, Top Stories,
Apr 4, 2024
Local high school students compete in Central Mass. Brain Bee at UMass Chan
Natick resident and Stanford Online High School student Rebecca Ahn outperformed other local high school students in the final round of the competition on March 16.
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, Graduate School of Biomedical Sciences, School of Medicine, Faculty, Psychiatry, Community, Anastasia Khvorova, Neurobiology, Neurology, Neurological Surgery, Radiology, RNA Therapeutics Institute, Latest News,
Oct 25, 2023
UMass Chan helps ‘Crack the Code’ at biotech career day in Worcester
Representatives from UMass Chan presented on several topics and career paths, including RNA Therapeutics Institute, ScienceLive, community and government relations, diversity and inclusion and media and arts in sciences.
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, Graduate School of Biomedical Sciences, School of Medicine, Watts Lab, Diversity and Inclusion Office , Employee, Faculty, Community, Anastasia Khvorova, Jonathan K. Watts, RNA Therapeutics Institute, Diversity, Latest News, Khvorova Lab, Angela Messmer-Blust, Top Stories,
Oct 2, 2023
Science for Living: Understanding preeclampsia, its toll on Black women and a promising therapeutic on the way
A new RNA therapeutic for preeclampsia is based on work by UMass Chan researchers and collaborating scientists. Researchers explain the importance of a multipronged approach to addressing factors underlying health disparities in this Science for Living article.
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, Graduate School of Biomedical Sciences, School of Medicine, Diversity and Inclusion Office , Faculty, Melissa Moore, Research, Anastasia Khvorova, RNA Therapeutics Institute, Diversity, Latest News, Khvorova Lab, Moore Lab, Top Stories,
May 15, 2023
MD/PhD student using NIH award to study onset of Huntington’s disease
MD/PhD student Jillian Belgrad has received an award from the National Institute of Neurological Disorders and Stroke to study the pathology that drives the development of Huntington’s disease symptoms.  
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, Graduate School of Biomedical Sciences, School of Medicine, Medicine, Student, Award, Research, Education, MD/PhD, Anastasia Khvorova, Radiology, RNA Therapeutics Institute, Aronin Lab, Program in Molecular Medicine, Neil Aronin, Latest News, Khvorova Lab, Top Stories,
Apr 12, 2023
UMass Chan scientists deliver siRNA therapy to lung
A multidisciplinary team of UMass Chan scientists has developed a technology for delivering siRNA molecules locally to lung tissue, providing the first evidence of a platform capable of delivering chemically modified siRNAs to the lungs nasally and achieving robust genetic silencing.
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, Graduate School of Biomedical Sciences, School of Medicine, Medicine, Watts Lab, Clinician, Faculty, Research, Postdoctoral Scholar, Katherine Fitzgerald, Anastasia Khvorova, Jonathan K. Watts, Novel Coronavirus, Wang Lab, Fitzerald Lab, RNA Therapeutics Institute, Program in Molecular Medicine, Latest News, Mello Lab, Khvorova Lab, Top Stories,
Dec 12, 2022
UMass Chan researcher Anastasia Khvorova named 2022 National Academy of Inventors Fellow
Anastasia Khvorova, PhD, is one of 169 academic inventors selected as a 2022 fellow of the National Academy of Inventors.
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, Graduate School of Biomedical Sciences, School of Medicine, Cancer Center, Faculty, Research, Anastasia Khvorova, RNA Therapeutics Institute,
Apr 5, 2022
Boston Marathon runners raise thousands for UMass Chan ALS research
ALS research at UMass Chan Medical School is the big beneficiary as select Boston Marathon runners raise tens of thousands of dollars each year. This year, five competitors in the April 18 event are running as part of the UMass Chan ALS Cellucci Fund Boston Marathon team and two sons of the late Jake Kennedy will run in support of the Jake Kennedy ALS Fund.
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, Graduate School of Biomedical Sciences, School of Medicine, Clinician, Faculty, Amyotrophic Lateral Sclerosis, Anastasia Khvorova, Neurology, RNA Therapeutics Institute, Latest News,
Nov 17, 2021
UMass Cancer Center funds five UMass Chan research projects
The UMass Cancer Center Pilot Project Program has awarded seed grants to five UMass Chan Medical School research projects to enable investigators to gather pilot data for external cancer-focused funding.
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, Graduate School of Biomedical Sciences, School of Medicine, Dermatology, Medicine, Cancer Center, Thomas Fazzio, Michael R. Green, Anastasia Khvorova, John Harris, Molecular, Cell and Cancer Biology, Population and Quantitative Health Sciences, RNA Therapeutics Institute, Fazzio Lab, Rajani Sadasivam, Marcus Ruscetti, Latest News, Prabhani Atukorale, Chan Zhou, Elise Stevens,
Apr 7, 2021
Erik Sontheimer co-leading efforts to develop gene editing toolkit by NIH Somatic Cell Genome Editing Consortium
Six UMass Medical School scientists are among the members of the National Institutes of Health’s Somatic Cell Genome Editing Consortium to publish a paper in Nature outlining the program’s goals.
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, Graduate School of Biomedical Sciences, School of Medicine, Cancer Center, Watts Lab, Faculty, Rare Disease, Guangping Gao, Anastasia Khvorova, Jonathan K. Watts, Scot A. Wolfe, Wen Xue, Wolfe Lab, Sontheimer Lab, Molecular, Cell and Cancer Biology, RNA Therapeutics Institute, Li Weibo Institute for Rare Diseases Research, Gao Lab, Microbiology and Physiological Systems,
Jan 12, 2021
Atalanta Therapeutics founded by UMass Medical School and three faculty members
Atalanta Therapeutics, a biotech founded by UMass Medical School and three faculty research scientists to pioneer treatment options for neurodegenerative diseases, has launched with financing by venture capital fund F-Prime Capital and strategic collaborations with Biogen and Genentech.
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, Graduate School of Biomedical Sciences, School of Medicine, Medicine, Clinician, Faculty, Craig C. Mello, Anastasia Khvorova, RNA Therapeutics Institute, Aronin Lab, Program in Molecular Medicine, Neil Aronin,
Dec 18, 2020
Inside the new mRNA vaccines for COVID-19
The new vaccines by Pfizer/BioNTech and Moderna use messenger RNA to stimulate the immune system to protect against COVID-19. These vaccines are the first of their kind and researchers at UMass Medical School are among the leading RNA biologists in the world.
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, Graduate School of Biomedical Sciences, School of Medicine, Office of Advancement, Faculty, Craig C. Mello, Anastasia Khvorova, Jonathan K. Watts, Novel Coronavirus, Biochemistry and Molecular Biotechnology, RNA Therapeutics Institute, Ambros Lab, Phillip Zamore, Program in Molecular Medicine,
Oct 14, 2020
UMass Medical School community mourns loss of Jake Kennedy
On behalf of the UMass Medical School community, we extend our sincere condolences to Jake Kennedy’s family and to all who knew and loved him. Jake Kennedy died Tuesday, Oct. 13, at age 65, in his Salem, N.H., home of amyotrophic lateral sclerosis.
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, Graduate School of Biomedical Sciences, School of Medicine, Michael F. Collins, Amyotrophic Lateral Sclerosis, Anastasia Khvorova, Neurology, RNA Therapeutics Institute, Program in Molecular Medicine,
May 11, 2020
Anastasia Khvorova elected director of the American Society of Gene and Cell Therapy
UMass Medical School RNA therapeutics expert Anastasia Khvorova, PhD, has been elected by the membership of the American Society of Gene and Cell Therapy to a three-year term as director-at-large/scientific & research council chair, which will begin at the 2020 ASGCT virtual annual meeting.
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, Graduate School of Biomedical Sciences, Cancer Center, Faculty, Anastasia Khvorova, RNA Therapeutics Institute,