Guramrit Singh, PhD
Associate Professor, The Ohio State University
Former RTI Lab: Postdoctoral Fellow, Moore Lab
Training Period: 2007 - 2013
Prior Academic Degree Institution: University of Colorado at Boulder
Every cell relies on precise and efficient gene expression. Multiple layers of controls operate at transcriptional (DNA to RNA) and post-transcriptional (RNA to protein) levels to govern faithful expression of genes into proteins. Much of the post-transcriptional fate of an mRNA rests in the hands of proteins that complex with RNA to form ribonucleoproteins (mRNPs). mRNP assembly begins as early as the precursor-to-mRNA (pre-mRNA) is transcribed, and proceeds as pre-mRNA is sculpted into mRNA during several processing steps. mRNPs continue to evolve throughout their lifetime, shedding proteins and acquiring others as they move from one cellular compartment to another and/or as they are acted upon by numerous macromolecular machines (e.g. the nuclear pore, the translating ribosome). How these dynamic RNA-protein machineries assemble and function to control mRNA fate remains under intense investigation to fully understand the fidelity and accuracy of gene expression.