Publications 2018
Bochenek MA, Veiseh O, Vegas AJ, McGarrigle JJ, Qi M, Marchese E, Omami M, Doloff JC, Mendoza-Elias J, Nourmohammadzadeh M, Khan A, Yeh CC, Xing Y, Isa D, Ghani S, Li J, Landry C, Bader AR, Olejnik K, Chen M, Hollister-Lock J, Wang Y, Greiner DL, Weir GC, Strand BL, Rokstad AMA, Lacik I, Langer R, Anderson DG, Oberholzer J. Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques. Nat Biomed Eng. 2018;2(11):810-21. Epub 2019/03/16. doi: 10.1038/s41551-018-0275-1. PubMed PMID: 30873298; PMCID: PMC6413527.
https://www.ncbi.nlm.nih.gov/pubmed/30873298
McManus M, Henderson J, Gautam A, Brody R, Weiss ER, Persaud D, Mick E, Luzuriaga K, Investigators P. Quantitative Human Immunodeficiency Virus (HIV)-1 Antibodies Correlate With Plasma HIV-1 RNA and Cell-associated DNA Levels in Children on Antiretroviral Therapy. Clin Infect Dis. 2018. Epub 2019/01/23. doi: 10.1093/cid/ciy753. PubMed PMID: 30668843; PMCID: PMC6495016.
https://www.ncbi.nlm.nih.gov/pubmed/30668843
Gawron MA, Duval M, Carbone C, Jaiswal S, Wallace A, Martin JC, 3rd, Dauphin A, Brehm MA, Greiner DL, Shultz LD, Luban J, Cavacini LA. Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1. J Immunol. 2019;202(3):799-804. Epub 2018/12/30. doi: 10.4049/jimmunol.1801085. PubMed PMID: 30593536; PMCID: PMC6344273.
https://www.ncbi.nlm.nih.gov/pubmed/30593536
Jung SM, Guertin DA. Insulin PACS a Punch in SIRT1 Activity. Mol Cell. 2018;72(6):917-9. Epub 2018/12/24. doi: 10.1016/j.molcel.2018.12.004. PubMed PMID: 30576653. https://www.ncbi.nlm.nih.gov/pubmed/30576653
Henriques F, Lopes MA, Franco FO, Knobl P, Santos KB, Bueno LL, Correa VA, Bedard AH, Guilherme A, Birbrair A, Peres SB, Farmer SR, Batista ML, Jr. Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival in Cancer Cachexia Syndrome. Sci Rep. 2018;8(1):18024. Epub 2018/12/24. doi: 10.1038/s41598-018-36626-3. PubMed PMID: 30575787; PMCID: PMC6303407.
https://www.ncbi.nlm.nih.gov/pubmed/30575787
McCauley SM, Kim K, Nowosielska A, Dauphin A, Yurkovetskiy L, Diehl WE, Luban J. Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines. Nat Commun. 2018;9(1):5305. Epub 2018/12/14. doi: 10.1038/s41467-018-07753-2. PubMed PMID: 30546110; PMCID: PMC6294009. https://www.ncbi.nlm.nih.gov/pubmed/30546110
Bolukbasi MF, Liu P, Luk K, Kwok SF, Gupta A, Amrani N, Sontheimer EJ, Zhu LJ, Wolfe SA. Publisher Correction: Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing. Nat Commun. 2018;9(1):5294. Epub 2018/12/12. doi: 10.1038/s41467-018-07776-9. PubMed PMID: 30531933; PMCID: PMC6288159. https://www.ncbi.nlm.nih.gov/pubmed/30531933
Amrani N, Gao XD, Liu P, Edraki A, Mir A, Ibraheim R, Gupta A, Sasaki KE, Wu T, Donohoue PD, Settle AH, Lied AM, McGovern K, Fuller CK, Cameron P, Fazzio TG, Zhu LJ, Wolfe SA, Sontheimer EJ. NmeCas9 is an intrinsically high-fidelity genome-editing platform. Genome Biol. 2018;19(1):214. Epub 2018/12/07. doi: 10.1186/s13059-018-1591-1. PubMed PMID: 30518407; PMCID: PMC6282386. https://www.ncbi.nlm.nih.gov/pubmed/30518407
Lee J, Mir A, Edraki A, Garcia B, Amrani N, Lou HE, Gainetdinov I, Pawluk A, Ibraheim R, Gao XD, Liu P, Davidson AR, Maxwell KL, Sontheimer EJ. Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins. MBio. 2018;9(6). Epub 2018/12/06. doi: 10.1128/mBio.02321-18. PubMed PMID: 30514786; PMCID: PMC6282205.
https://www.ncbi.nlm.nih.gov/pubmed/30514786
Dumas SN, Guo CA, Kim JK, Friedline RH, Ntambi JM. Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin, adipose tissue and liver. Biochem Biophys Res Commun. 2019;508(1):87-91. Epub 2018/11/25. doi: 10.1016/j.bbrc.2018.11.083. PubMed PMID: 30470572; PMCID: PMC6309575.
https://www.ncbi.nlm.nih.gov/pubmed/30470572
Saleiro D, Blyth GT, Kosciuczuk EM, Ozark PA, Majchrzak-Kita B, Arslan AD, Fischietti M, Reddy NK, Horvath CM, Davis RJ, Fish EN, Platanias LC. IFN-gamma-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5. Sci Signal. 2018;11(557). Epub 2018/11/22. doi: 10.1126/scisignal.aap9921. PubMed PMID: 30459284. https://www.ncbi.nlm.nih.gov/pubmed/30459284
Swygert SG, Senapati S, Bolukbasi MF, Wolfe SA, Lindsay S, Peterson CL. SIR proteins create compact heterochromatin fibers. Proc Natl Acad Sci U S A. 2018;115(49):12447-52. Epub 2018/11/21. doi: 10.1073/pnas.1810647115. PubMed PMID: 30455303; PMCID: PMC6298083.
https://www.ncbi.nlm.nih.gov/pubmed/30455303
Turanov AA, Lo A, Hassler MR, Makris A, Ashar-Patel A, Alterman JF, Coles AH, Haraszti RA, Roux L, Godinho B, Echeverria D, Pears S, Iliopoulos J, Shanmugalingam R, Ogle R, Zsengeller ZK, Hennessy A, Karumanchi SA, Moore MJ, Khvorova A. RNAi modulation of placental sFLT1 for the treatment of preeclampsia. Nat Biotechnol. 2018. Epub 2018/11/20. doi: 10.1038/nbt.4297. PubMed PMID: 30451990; PMCID: PMC6526074.
https://www.ncbi.nlm.nih.gov/pubmed/30451990
Bolukbasi MF, Liu P, Luk K, Kwok SF, Gupta A, Amrani N, Sontheimer EJ, Zhu LJ, Wolfe SA. Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing. Nat Commun. 2018;9(1):4856. Epub 2018/11/20. doi: 10.1038/s41467-018-07310-x. PubMed PMID: 30451839; PMCID: PMC6242970. https://www.ncbi.nlm.nih.gov/pubmed/30451839
Quitadamo B, Peters PJ, Koch M, Luzuriaga K, Cheng-Mayer C, Clapham PR, Gonzalez-Perez MP. No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications. Arch Virol. 2019;164(2):473-82. Epub 2018/11/12. doi: 10.1007/s00705-018-4094-1. PubMed PMID: 30415390; PMCID: PMC6369005. https://www.ncbi.nlm.nih.gov/pubmed/30415390
Smith JL, Mou H, Xue W. Understanding and repurposing CRISPR-mediated alternative splicing. Genome Biol. 2018;19(1):184. Epub 2018/11/08. doi: 10.1186/s13059-018-1565-3. PubMed PMID: 30400804; PMCID: PMC6219182.
https://www.ncbi.nlm.nih.gov/pubmed/30400804
Liu B, Li Y, Stackpole EE, Novak A, Gao Y, Zhao Y, Zhao X, Richter JD. Regulatory discrimination of mRNAs by FMRP controls mouse adult neural stem cell differentiation. Proc Natl Acad Sci U S A. 2018;115(48):E11397-E405. Epub 2018/10/31. doi: 10.1073/pnas.1809588115. PubMed PMID: 30373821; PMCID: PMC6275535. https://www.ncbi.nlm.nih.gov/pubmed/30373821
Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM. Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Nat Chem Biol. 2018;14(11):1021-31. Epub 2018/10/18. doi: 10.1038/s41589-018-0132-2. PubMed PMID: 30327559; PMCID: PMC6245668.
https://www.ncbi.nlm.nih.gov/pubmed/30327559
Hamza Z, El-Hashash M, Aly S, Hathout A, Soto E, Sabry B, Ostroff G. Preparation and characterization of yeast cell wall beta-glucan encapsulated humic acid nanoparticles as an enhanced aflatoxin B1 binder. Carbohydr Polym. 2019;203:185-92. Epub 2018/10/16. doi: 10.1016/j.carbpol.2018.08.047. PubMed PMID: 30318202. https://www.ncbi.nlm.nih.gov/pubmed/30318202
Yurkovetskiy L, Guney MH, Kim K, Goh SL, McCauley S, Dauphin A, Diehl WE, Luban J. Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex. Nat Microbiol. 2018;3(12):1354-61. Epub 2018/10/10. doi: 10.1038/s41564-018-0256-x. PubMed PMID: 30297740; PMCID: PMC6258279.
https://www.ncbi.nlm.nih.gov/pubmed/30297740
Zhang G, Tu S, Yu T, Zhang XO, Parhad SS, Weng Z, Theurkauf WE. Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin. Cell Rep. 2018;24(13):3413-22 e4. Epub 2018/09/27. doi: 10.1016/j.celrep.2018.08.081. PubMed PMID: 30257203; PMCID: PMC6235161. https://www.ncbi.nlm.nih.gov/pubmed/30257203
Ibraheim R, Song CQ, Mir A, Amrani N, Xue W, Sontheimer EJ. All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo. Genome Biol. 2018;19(1):137. Epub 2018/09/21. doi: 10.1186/s13059-018-1515-0. PubMed PMID: 30231914; PMCID: PMC6146650.
https://www.ncbi.nlm.nih.gov/pubmed/30231914
Alexander MP, Fiering SN, Ostroff GR, Cramer RA, Mullins DW. Beta-glucan-induced inflammatory monocytes mediate antitumor efficacy in the murine lung. Cancer Immunol Immunother. 2018;67(11):1731-42. Epub 2018/09/01. doi: 10.1007/s00262-018-2234-9. PubMed PMID: 30167860.
https://www.ncbi.nlm.nih.gov/pubmed/30167860
Zhang XO, Fu Y, Mou H, Xue W, Weng Z. The temporal landscape of recursive splicing during Pol II transcription elongation in human cells. PLoS Genet. 2018;14(8):e1007579. Epub 2018/08/28. doi: 10.1371/journal.pgen.1007579. PubMed PMID: 30148885; PMCID: PMC6110456.
https://www.ncbi.nlm.nih.gov/pubmed/30148885
Hung CY, Zhang H, Castro-Lopez N, Ostroff GR, Khoshlenar P, Abraham A, Cole GT, Negron A, Forsthuber T, Peng T, Galgiani JN, Ampel NM, Yu JJ. Glucan-Chitin Particles Enhance Th17 Response and Improve Protective Efficacy of a Multivalent Antigen (rCpa1) against Pulmonary Coccidioides posadasii Infection. Infect Immun. 2018;86(11). Epub 2018/08/15. doi: 10.1128/IAI.00070-18. PubMed PMID: 30104216; PMCID: PMC6204714.
https://www.ncbi.nlm.nih.gov/pubmed/30104216
Wang D, Li J, Song CQ, Tran K, Mou H, Wu PH, Tai PWL, Mendonca CA, Ren L, Wang BY, Su Q, Gessler DJ, Zamore PD, Xue W, Gao G. Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice. Nat Biotechnol. 2018;36(9):839-42. Epub 2018/08/14. doi: 10.1038/nbt.4219. PubMed PMID: 30102296; PMCID: PMC6126964.
https://www.ncbi.nlm.nih.gov/pubmed/30102296
Lopes MA, Oliveira Franco F, Henriques F, Peres SB, Batista ML, Jr. LLC tumor cells-derivated factors reduces adipogenesis in co-culture system. Heliyon. 2018;4(7):e00708. Epub 2018/08/11. doi: 10.1016/j.heliyon.2018.e00708. PubMed PMID: 30094378; PMCID: PMC6071679.
https://www.ncbi.nlm.nih.gov/pubmed/30094378
Landry BD, Leete T, Richards R, Cruz-Gordillo P, Schwartz HR, Honeywell ME, Ren G, Schwartz AD, Peyton SR, Lee MJ. Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells. Mol Syst Biol. 2018;14(8):e8322. Epub 2018/08/08. doi: 10.15252/msb.20188322. PubMed PMID: 30082272; PMCID: PMC6078165.
https://www.ncbi.nlm.nih.gov/pubmed/30082272
Lessard SJ, MacDonald TL, Pathak P, Han MS, Coffey VG, Edge J, Rivas DA, Hirshman MF, Davis RJ, Goodyear LJ. JNK regulates muscle remodeling via myostatin/SMAD inhibition. Nat Commun. 2018;9(1):3030. Epub 2018/08/04. doi: 10.1038/s41467-018-05439-3. PubMed PMID: 30072727; PMCID: PMC6072737. https://www.ncbi.nlm.nih.gov/pubmed/30072727
Braun MC, Castillo-Ruiz A, Indic P, Jung DY, Kim JK, Brown RH, Jr., Swoap SJ, Schwartz WJ. Defective daily temperature regulation in a mouse model of amyotrophic lateral sclerosis. Exp Neurol. 2019;311:305-12. Epub 2018/07/22. doi: 10.1016/j.expneurol.2018.07.008. PubMed PMID: 30031021; PMCID: PMC6263852. https://www.ncbi.nlm.nih.gov/pubmed/30031021
Guilherme A, Pedersen DJ, Henriques F, Bedard AH, Henchey E, Kelly M, Morgan DA, Rahmouni K, Czech MP. Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis. Mol Metab. 2018;16:116-25. Epub 2018/07/15. doi: 10.1016/j.molmet.2018.06.014. PubMed PMID: 30005879; PMCID: PMC6157614.
https://www.ncbi.nlm.nih.gov/pubmed/30005879
Mir A, Alterman JF, Hassler MR, Debacker AJ, Hudgens E, Echeverria D, Brodsky MH, Khvorova A, Watts JK, Sontheimer EJ. Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing. Nat Commun. 2018;9(1):2641. Epub 2018/07/08. doi: 10.1038/s41467-018-05073-z. PubMed PMID: 29980686; PMCID: PMC6035171.
https://www.ncbi.nlm.nih.gov/pubmed/29980686
Ambros V, Ruvkun G. Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs. Genetics. 2018;209(3):651-73. Epub 2018/07/04. doi: 10.1534/genetics.118.300291. PubMed PMID: 29967059; PMCID: PMC6028246. https://www.ncbi.nlm.nih.gov/pubmed/29967059
Gabriel GC, Pazour GJ, Lo CW. Congenital Heart Defects and Ciliopathies Associated With Renal Phenotypes. Front Pediatr. 2018;6:175. Epub 2018/07/03. doi: 10.3389/fped.2018.00175. PubMed PMID: 29963541; PMCID: PMC6013576. https://www.ncbi.nlm.nih.gov/pubmed/29963541
Barutcu SA, Girnius N, Vernia S, Davis RJ. Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy. Autophagy. 2018;14(9):1586-95. Epub 2018/06/29. doi: 10.1080/15548627.2018.1466013. PubMed PMID: 29950132; PMCID: PMC6135577. https://www.ncbi.nlm.nih.gov/pubmed/29950132
Kernfeld EM, Genga RMJ, Neherin K, Magaletta ME, Xu P, Maehr R. A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation. Immunity. 2018;48(6):1258-70 e6. Epub 2018/06/10. doi: 10.1016/j.immuni.2018.04.015. PubMed PMID: 29884461; PMCID: PMC6013397. https://www.ncbi.nlm.nih.gov/pubmed/29884461
Yu B, Lin YA, Parhad SS, Jin Z, Ma J, Theurkauf WE, Zhang ZZ, Huang Y. Structural insights into Rhino-Deadlock complex for germline piRNA cluster specification. EMBO Rep. 2018;19(7). Epub 2018/06/03. doi: 10.15252/embr.201745418. PubMed PMID: 29858487; PMCID: PMC6030695.
https://www.ncbi.nlm.nih.gov/pubmed/29858487
Girnius N, Edwards YJ, Garlick DS, Davis RJ. The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation. Elife. 2018;7. Epub 2018/06/02. doi: 10.7554/eLife.36389. PubMed PMID: 29856313; PMCID: PMC5984035.
https://www.ncbi.nlm.nih.gov/pubmed/29856313
Magoulas PL, Shchelochkov OA, Bainbridge MN, Ben-Shachar S, Yatsenko S, Potocki L, Lewis RA, Searby C, Marcogliese AN, Elghetany MT, Zapata G, Hernandez PP, Gadkari M, Einhaus D, Muzny DM, Gibbs RA, Bertuch AA, Scott DA, Corvera S, Franco LM. Syndromic congenital myelofibrosis associated with a loss-of-function variant in RBSN. Blood. 2018;132(6):658-62. Epub 2018/05/23. doi: 10.1182/blood-2017-12-824433. PubMed PMID: 29784638; PMCID: PMC6085991. https://www.ncbi.nlm.nih.gov/pubmed/29784638
Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A. Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. Transplantation. 2018;102(8):1223-9. Epub 2018/05/22. doi: 10.1097/TP.0000000000002217. PubMed PMID: 29781950.
https://www.ncbi.nlm.nih.gov/pubmed/29781950
Stone NP, Hilbert BJ, Hidalgo D, Halloran KT, Lee J, Sontheimer EJ, Kelch BA. A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein. Structure. 2018;26(7):936-47 e3. Epub 2018/05/22. doi: 10.1016/j.str.2018.04.008. PubMed PMID: 29779790; PMCID: PMC6277972.
https://www.ncbi.nlm.nih.gov/pubmed/29779790
Hu Y, Miller M, Zhang B, Nguyen TT, Nielsen MK, Aroian RV. In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites. PLoS Negl Trop Dis. 2018;12(5):e0006506. Epub 2018/05/19. doi: 10.1371/journal.pntd.0006506. PubMed PMID: 29775454; PMCID: PMC5979042. https://www.ncbi.nlm.nih.gov/pubmed/29775454
Hu Y, Nguyen TT, Lee ACY, Urban JF, Jr., Miller MM, Zhan B, Koch DJ, Noon JB, Abraham A, Fujiwara RT, Bowman DD, Ostroff GR, Aroian RV. Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure. Int J Parasitol Drugs Drug Resist. 2018;8(2):287-94. Epub 2018/05/18. doi: 10.1016/j.ijpddr.2018.05.001. PubMed PMID: 29772478; PMCID: PMC6039361.
https://www.ncbi.nlm.nih.gov/pubmed/29772478
Tai PWL, Xie J, Fong K, Seetin M, Heiner C, Su Q, Weiand M, Wilmot D, Zapp ML, Gao G. Adeno-associated Virus Genome Population Sequencing Achieves Full Vector Genome Resolution and Reveals Human-Vector Chimeras. Mol Ther Methods Clin Dev. 2018;9:130-41. Epub 2018/05/17. doi: 10.1016/j.omtm.2018.02.002. PubMed PMID: 29766023; PMCID: PMC5948225. https://www.ncbi.nlm.nih.gov/pubmed/29766023
Li Q, Nirala NK, Nie Y, Chen HJ, Ostroff G, Mao J, Wang Q, Xu L, Ip YT. Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth. Dev Cell. 2018;45(4):433-49 e6. Epub 2018/05/15. doi: 10.1016/j.devcel.2018.04.014. PubMed PMID: 29754801.
https://www.ncbi.nlm.nih.gov/pubmed/29754801
Gao XD, Tu LC, Mir A, Rodriguez T, Ding Y, Leszyk J, Dekker J, Shaffer SA, Zhu LJ, Wolfe SA, Sontheimer EJ. C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2. Nat Methods. 2018;15(6):433-6. Epub 2018/05/08. doi: 10.1038/s41592-018-0006-2. PubMed PMID: 29735996; PMCID: PMC6202229.
https://www.ncbi.nlm.nih.gov/pubmed/29735996
Deepe GS, Jr., Buesing WR, Ostroff GR, Abraham A, Specht CA, Huang H, Levitz SM. Vaccination with an alkaline extract of Histoplasma capsulatum packaged in glucan particles confers protective immunity in mice. Vaccine. 2018;36(23):3359-67. Epub 2018/05/08. doi: 10.1016/j.vaccine.2018.04.047. PubMed PMID: 29729993; PMCID: PMC5960637.
https://www.ncbi.nlm.nih.gov/pubmed/29729993
Brese RL, Gonzalez-Perez MP, Koch M, O'Connell O, Luzuriaga K, Somasundaran M, Clapham PR, Dollar JJ, Nolan DJ, Rose R, Lamers SL. Ultradeep single-molecule real-time sequencing of HIV envelope reveals complete compartmentalization of highly macrophage-tropic R5 proviral variants in brain and CXCR4-using variants in immune and peripheral tissues. J Neurovirol. 2018;24(4):439-53. Epub 2018/04/25. doi: 10.1007/s13365-018-0633-5. PubMed PMID: 29687407.
https://www.ncbi.nlm.nih.gov/pubmed/29687407
Osborn MF, Coles AH, Golebiowski D, Echeverria D, Moazami MP, Watts JK, Sena-Esteves M, Khvorova A. Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs. Mol Cancer Ther. 2018;17(6):1251-8. Epub 2018/04/15. doi: 10.1158/1535-7163.MCT-17-1144. PubMed PMID: 29654062; PMCID: PMC5984726. https://www.ncbi.nlm.nih.gov/pubmed/29654062
Desai PB, San Agustin JT, Stuck MW, Jonassen JA, Bates CM, Pazour GJ. Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Mech Dev. 2018;151:10-7. Epub 2018/04/08. doi: 10.1016/j.mod.2018.04.001. PubMed PMID: 29626631; PMCID: PMC5972074.
https://www.ncbi.nlm.nih.gov/pubmed/29626631
Ghorpade DS, Ozcan L, Zheng Z, Nicoloro SM, Shen Y, Chen E, Bluher M, Czech MP, Tabas I. Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance. Nature. 2018;555(7698):673-7. Epub 2018/03/22. doi: 10.1038/nature26138. PubMed PMID: 29562231; PMCID: PMC6021131. https://www.ncbi.nlm.nih.gov/pubmed/29562231
Morel C, Sherrin T, Kennedy NJ, Forest KH, Avcioglu Barutcu S, Robles M, Carpenter-Hyland E, Alfulaij N, Standen CL, Nichols RA, Benveniste M, Davis RJ, Todorovic C. JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. J Neurosci. 2018;38(15):3708-28. Epub 2018/03/16. doi: 10.1523/JNEUROSCI.1913-17.2018. PubMed PMID: 29540552; PMCID: PMC5895995.
https://www.ncbi.nlm.nih.gov/pubmed/29540552
Eguether T, Cordelieres FP, Pazour GJ. Intraflagellar transport is deeply integrated in hedgehog signaling. Mol Biol Cell. 2018;29(10):1178-89. Epub 2018/03/16. doi: 10.1091/mbc.E17-10-0600. PubMed PMID: 29540531; PMCID: PMC5935068. https://www.ncbi.nlm.nih.gov/pubmed/29540531
Huang LH, Melton EM, Li H, Sohn P, Jung D, Tsai CY, Ma T, Sano H, Ha H, Friedline RH, Kim JK, Usherwood E, Chang CCY, Chang TY. Myeloid-specific Acat1 ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity. Am J Physiol Endocrinol Metab. 2018;315(3):E340-E56. Epub 2018/03/14. doi: 10.1152/ajpendo.00174.2017. PubMed PMID: 29533741; PMCID: PMC6171008.
https://www.ncbi.nlm.nih.gov/pubmed/29533741
Girnius N, Edwards YJK, Davis RJ. The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution. Cell Death Differ. 2018;25(9):1702-15. Epub 2018/03/08. doi: 10.1038/s41418-018-0081-z. PubMed PMID: 29511338; PMCID: PMC6143629.
https://www.ncbi.nlm.nih.gov/pubmed/29511338
Seo Y, Kingsley S, Walker G, Mondoux MA, Tissenbaum HA. Metabolic shift from glycogen to trehalose promotes lifespan and healthspan in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2018;115(12):E2791-E800. Epub 2018/03/08. doi: 10.1073/pnas.1714178115. PubMed PMID: 29511104; PMCID: PMC5866546. https://www.ncbi.nlm.nih.gov/pubmed/29511104
Caracciolo V, Young J, Gonzales D, Ni Y, Flowers SJ, Summer R, Waldman SA, Kim JK, Jung DY, Noh HL, Kim T, Blackshear PJ, O'Connell D, Bauer RC, Kallen CB. Myeloid-specific deletion of Zfp36 protects against insulin resistance and fatty liver in diet-induced obese mice. Am J Physiol Endocrinol Metab. 2018;315(4):E676-E93. Epub 2018/03/07. doi: 10.1152/ajpendo.00224.2017. PubMed PMID: 29509432; PMCID: PMC6230714.
https://www.ncbi.nlm.nih.gov/pubmed/29509432
Edraki A, Sontheimer EJ. CRISPRs from scratch. Nat Microbiol. 2018;3(3):261-2. Epub 2018/02/22. doi: 10.1038/s41564-018-0115-9. PubMed PMID: 29463924. https://www.ncbi.nlm.nih.gov/pubmed/29463924
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