microRNAs Control Antiviral Immune Response, Cell Death and Chemotaxis Pathways in Human Neuronal Precursor Cells (NPCs) during Zika Virus Infection. Polonio CM, da Silva P, Russo FB, Hyppolito BRN, Zanluqui NG, Benazzato C, Beltrão-Braga PCB, Muxel SM, Peron JPS. Int J Mol Sci. 2022 Sep 7;23(18):10282. https://pubmed.ncbi.nlm.nih.gov/36142200/
SARS-CoV-2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytes. de Oliveira LG, de Souza Angelo Y, Yamamoto P, Carregari VC, Crunfli F, Reis-de-Oliveira G, Costa L, Vendramini PH, Duque ÉA, Dos Santos NB, Firmino EM, Paiva IM, Almeida GM, Sebollela A, Polonio CM, Zanluqui NG, de Oliveira MG, da Silva P, Davanzo GG, Ayupe MC, Salgado CL, de Souza Filho AF, de Araújo MV, Silva-Pereira TT, de Almeida Campos AC, Góes LGB, Dos Passos Cunha M, Caldini EG, D'Império Lima MR, Fonseca DM, de Sá Guimarães AM, Minoprio PC, Munhoz CD, Mori CMC, Moraes-Vieira PM, Cunha TM, Martins-de-Souza D, Peron JPS. J Neurochem. 2022 Oct;163(2):113-132. https://pubmed.ncbi.nlm.nih.gov/35880385/
Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient. Cunha MDP, Vilela APP, Molina CV, Acuña SM, Muxel SM, Barroso VM, Baroni S, Gomes de Oliveira L, Angelo YS, Peron JPS, Góes LGB, Campos ACA, Minóprio P. Front Med (Lausanne). 2021 Nov 26;8:760170. https://pubmed.ncbi.nlm.nih.gov/34901074/
Reactive Oxygen Species (ROS) Are Not a Key Determinant for Zika Virus-Induced Apoptosis in SH-SY5Y Neuroblastoma Cells. Mendonça-Vieira LR, Aníbal-Silva CE, Menezes-Neto A, Azevedo EAN, Zanluqui NG, Peron JPS, Franca RFO. Viruses. 2021 Oct 20;13(11):2111. https://pubmed.ncbi.nlm.nih.gov/34834918/
Human Fallopian Tube - Derived Mesenchymal Stem Cells Inhibit Experimental Autoimmune Encephalomyelitis by Suppressing Th1/Th17 Activation and Migration to Central Nervous System. de Freitas CL, Polonio CM, Brandão WN, Rossato C, Zanluqui NG, de Oliveira LG, de Oliveira MG, Evangelista LP, Halpern S, Maluf M, Czresnia CE, Perin P, de Almeida DC, Peron JPS. Stem Cell Rev Rep. 2022 Feb;18(2):609-625. doi: 10.1007/s12015-021-10226-7. https://pubmed.ncbi.nlm.nih.gov/34453694/
Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice. Silva-Filho JL, de Oliveira LG, Monteiro L, Parise PL, Zanluqui NG, Polonio CM, de Freitas CL, Toledo-Teixeira DA, de Souza WM, Bittencourt N, Amorim MR, Forato J, Muraro SP, de Souza GF, Martini MC, Bispo-Dos-Santos K, Vieira A, Judice CC, Pastore GM, Amaral E, Passini Junior R, Mayer-Milanez HMBP, Ribeiro-do-Valle CC, Calil R, Renato Bennini Junior J, Lajos GJ, Altemani A, Nolasco da Silva MT, Carolina Coan A, Francisca Colella-Santos M, von Zuben APB, Vinolo MAR, Arns CW, Catharino RR, Costa ML, Angerami RN, Freitas ARR, Resende MR, Garcia MT, Luiza Moretti M, Renia L, Ng LFP, Rothlin CV, Costa FTM, Peron JPS, Proença-Modena JL. Brain Behav Immun. 2021 Oct;97:260-274. https://pubmed.ncbi.nlm.nih.gov/34390806/
Murine endometrial-derived mesenchymal stem cells suppress experimental autoimmune encephalomyelitis depending on indoleamine-2,3-dioxygenase expression. Manganeli Polonio C, Longo de Freitas C, Garcia de Oliveira M, Rossato C, Nogueira Brandão W, Ghabdan Zanluqui N, Gomes de Oliveira L, Ayumi Nishiyama Mimura L, Braga Barros Silva M, Lúcia Garcia Calich V, Gil Nisenbaum M, Halpern S, Evangelista L, Maluf M, Perin P, Eduardo Czeresnia C, Schatzmann Peron JP. Clin Sci (Lond). 2021 May 14;135(9):1065-1082. https://pubmed.ncbi.nlm.nih.gov/33960391/
Protective Immunity to Dengue Virus-Induced by DNA Vaccines Encoding Nonstructural Proteins in a Lethal Challenge Immunocompetent Mouse Model. Alves RPDS, Andreata-Santos R, de Freitas CL, Pereira LR, Fabris-Maeda DLN, Rodrigues-Jesus MJ, Pereira SS, Carvalho AAVB, Sales NS, Peron JPS, Amorim JH, Ferreira LCS. Front Med Technol. 2020 Oct 30;2:558984. https://pubmed.ncbi.nlm.nih.gov/35047876/
AHR is a Zika virus host factor and a candidate target for antiviral therapy. Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, Li Z, Romorini L, Rodriguez Varela MS, Rothhammer V, Barroso A, Tjon EC, Sanmarco LM, Takenaka MC, Modaresi SMS, Gutiérrez-Vázquez C, Zanluqui NG, Dos Santos NB, Munhoz CD, Wang Z, Damonte EB, Sherr D, Gehrke L, Peron JPS, Garcia CC, Quintana FJ. Nat Neurosci. 2020 Aug;23(8):939-951. https://pubmed.ncbi.nlm.nih.gov/32690969/
ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19. Pinto BGG, Oliveira AER, Singh Y, Jimenez L, Gonçalves ANA, Ogava RLT, Creighton R, Schatzmann Peron JP, Nakaya HI. J Infect Dis. 2020 Jul 23;222(4):556-563. https://pubmed.ncbi.nlm.nih.gov/32526012/
NLRP3 gain-of-function in CD4+ T lymphocytes ameliorates experimental autoimmune encephalomyelitis. Braga TT, Brandao WN, Azevedo H, Terra FF, Melo ACL, Pereira FV, Andrade-Oliveira V, Hiyane MI, Peron JPS, Camara NOS. Clin Sci (Lond). 2019 Sep 13;133(17):1901-1916. https://pubmed.ncbi.nlm.nih.gov/32428113/
High dose of dexamethasone protects against EAE-induced motor deficits but impairs learning/memory in C57BL/6 mice. Dos Santos N, Novaes LS, Dragunas G, Rodrigues JR, Brandão W, Camarini R, Peron JPS, Munhoz CD. Sci Rep. 2019 Apr 30;9(1):6673. https://pubmed.ncbi.nlm.nih.gov/31040362/
Stem cells from human-exfoliated deciduous teeth reduce tissue-infiltrating inflammatory cells improving clinical signs in experimental autoimmune encephalomyelitis. Rossato C, Brandão WN, Castro SBR, de Almeida DC, Maranduba CMC, Camara NOS, Peron JPS, Silva FS. Biologicals. 2017 Sep;49:62-68. https://pubmed.ncbi.nlm.nih.gov/28666719/
Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys. Abbink P, Larocca RA, De La Barrera RA, Bricault CA, Moseley ET, Boyd M, Kirilova M, Li Z, Ng'ang'a D, Nanayakkara O, Nityanandam R, Mercado NB, Borducchi EN, Agarwal A, Brinkman AL, Cabral C, Chandrashekar A, Giglio PB, Jetton D, Jimenez J, Lee BC, Mojta S, Molloy K, Shetty M, Neubauer GH, Stephenson KE, Peron JP, Zanotto PM, Misamore J, Finneyfrock B, Lewis MG, Alter G, Modjarrad K, Jarman RG, Eckels KH, Michael NL, Thomas SJ, Barouch DH. Science. 2016 Sep 9;353(6304):1129-32. https://pubmed.ncbi.nlm.nih.gov/27492477/
Vaccine protection against Zika virus from Brazil. Larocca RA, Abbink P, Peron JP, Zanotto PM, Iampietro MJ, Badamchi-Zadeh A, Boyd M, Ng'ang'a D, Kirilova M, Nityanandam R, Mercado NB, Li Z, Moseley ET, Bricault CA, Borducchi EN, Giglio PB, Jetton D, Neubauer G, Nkolola JP, Maxfield LF, De La Barrera RA, Jarman RG, Eckels KH, Michael NL, Thomas SJ, Barouch DH. Nature. 2016 Aug 25;536(7617):474-8. https://pubmed.ncbi.nlm.nih.gov/27355570/
The Brazilian Zika virus strain causes birth defects in experimental models. Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JL, Guimarães KP, Benazzato C, Almeida N, Pignatari GC, Romero S, Polonio CM, Cunha I, Freitas CL, Brandão WN, Rossato C, Andrade DG, Faria Dde P, Garcez AT, Buchpigel CA, Braconi CT, Mendes E, Sall AA, Zanotto PM, Peron JP, Muotri AR, Beltrão-Braga PC. Nature. 2016 Jun 9;534(7606):267-71. https://pubmed.ncbi.nlm.nih.gov/27279226/
Simvastatin ameliorates experimental autoimmune encephalomyelitis by inhibiting Th1/Th17 response and cellular infiltration. de Oliveira DM, de Oliveira EM, Ferrari Mde F, Semedo P, Hiyane MI, Cenedeze MA, Pacheco-Silva A, Câmara NO, Peron JP. Inflammopharmacology. 2015 Dec;23(6):343-54. https://pubmed.ncbi.nlm.nih.gov/26559850/
Human Tubal-Derived Mesenchymal Stromal Cells Associated with Low Level Laser Therapy Significantly Reduces Cigarette Smoke-Induced COPD in C57BL/6 mice. Peron JP, de Brito AA, Pelatti M, Brandão WN, Vitoretti LB, Greiffo FR, da Silveira EC, Oliveira-Junior MC, Maluf M, Evangelista L, Halpern S, Nisenbaum MG, Perin P, Czeresnia CE, Câmara NO, Aimbire F, Vieira RP, Zatz M, de Oliveira AP. PLoS One. 2015 Aug 31;10(8):e0136942. https://pubmed.ncbi.nlm.nih.gov/26322981/
Human endometrial-derived mesenchymal stem cells suppress inflammation in the central nervous system of EAE mice. Peron JP, Jazedje T, Brandão WN, Perin PM, Maluf M, Evangelista LP, Halpern S, Nisenbaum MG, Czeresnia CE, Zatz M, Câmara NO, Rizzo LV. Stem Cell Rev Rep. 2012 Sep;8(3):940-52. https://pubmed.ncbi.nlm.nih.gov/22180029/
Oral tolerance reduces Th17 cells as well as the overall inflammation in the central nervous system of EAE mice. Peron JP, Yang K, Chen ML, Brandao WN, Basso AS, Commodaro AG, Weiner HL, Rizzo LV. J Neuroimmunol. 2010 Oct 8;227(1-2):10-7. https://pubmed.ncbi.nlm.nih.gov/20580440/
Deficiency of thrombospondin-1 reduces Th17 differentiation and attenuates experimental autoimmune encephalomyelitis. Yang K, Vega JL, Hadzipasic M, Schatzmann Peron JP, Zhu B, Carrier Y, Masli S, Rizzo LV, Weiner HL. J Autoimmun. 2009 Mar;32(2):94-103. https://pubmed.ncbi.nlm.nih.gov/19181483/
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, Flavell RA, Kuchroo VK, Oukka M, Weiner HL. Nat Immunol. 2007 Dec;8(12):1380-9. https://pubmed.ncbi.nlm.nih.gov/17994022/
Direct and indirect impact of SARS-CoV-2 on the brain. Peron JPS. Hum Genet. 2023 Apr 1:1-10. https://pubmed.ncbi.nlm.nih.gov/37004544/
ZIKV Infection and miRNA Network in Pathogenesis and Immune Response. Polonio CM, Peron JPS. Viruses. 2021 Oct 4;13(10):1992. https://pubmed.ncbi.nlm.nih.gov/34696422/
Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation. de Oliveira LG, Angelo YS, Iglesias AH, Peron JPS. Front Immunol. 2021 Mar 16;12:624919. https://pubmed.ncbi.nlm.nih.gov/33796100/
Neurological Complications of the COVID-19 Pandemic: What Have We Got So Far? Bandeira IP, Schlindwein MAM, Breis LC, Peron JPS, Gonçalves MVM. Adv Exp Med Biol. 2021;1321:21-31. https://pubmed.ncbi.nlm.nih.gov/33656710/
Neuroinflammation at single cell level: What is new? Brandão WN, De Oliveira MG, Andreoni RT, Nakaya H, Farias AS, Peron JPS. J Leukoc Biol. 2020 Oct;108(4):1129-1137. https://pubmed.ncbi.nlm.nih.gov/32779279/
Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2 Overexpression, Shedding, and Antibody-dependent Enhancement (ADE). Peron JPS, Nakaya H. Clinics (Sao Paulo). 2020;75:e1912. https://pubmed.ncbi.nlm.nih.gov/32428113/
COVID-19 Pandemic and Dysbiosis: Can the Ivermectin Hysteria Leads to an Increase of Autoimmune Neuroinflammatory Diseases? Peron JPS, Nakaya HI, Schlindwein MAM, Gonçalves MVM. Crit Rev Immunol. 2020;40(6):537-542. https://pubmed.ncbi.nlm.nih.gov/33900697/
Viral receptors for flaviviruses: Not only gatekeepers. Oliveira LG, Peron JPS. J Leukoc Biol. 2019 Sep;106(3):695-701. https://pubmed.ncbi.nlm.nih.gov/31063609/
Zika virus congenital syndrome: experimental models and clinical aspects. Polonio CM, de Freitas CL, Zanluqui NG, Peron JPS. J Venom Anim Toxins Incl Trop Dis. 2017 Sep 15;23:41. https://pubmed.ncbi.nlm.nih.gov/28932235/
Zika virus-associated brain damage: animal models and open issues. Di Guardo G, Braga PB, Peron JP. Emerg Microbes Infect. 2016 Sep 21;5(9):e106. https://pubmed.ncbi.nlm.nih.gov/27651092/
It takes guts for tolerance: the phenomenon of oral tolerance and the regulation of autoimmune response. Peron JP, de Oliveira AP, Rizzo LV. Autoimmun Rev. 2009 Sep;9(1):1-4. https://pubmed.ncbi.nlm.nih.gov/19224711/
