Laam (Magnolia) Pak
| Instructor |  |
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| Ph.D.: 2012, University of British Columbia | ||
| Postdoctoral research: UMass Chan Medical School | ||
| Office: | UMass Chan Medical School 364 Plantation Street, LRB-670-C Worcester, MA 01605 |
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| Phone: | 508-856-5318 | |
| Email: | Magnolia.Pak@umassmed.edu | |
Research
My research focuses on investigating the epigenetic and transcriptional regulatory mechanisms underlying the epithelial-mesenchymal transition (EMT) using breast cancer as a model system. Using a candidate-based RNAi screening strategy, I have identified the histone acetyltransferase EP300 as a suppressor of EMT in human breast epithelial cells and shown that it suppresses EMT by repressing expression of TGFB1, a known key EMT inducer. My work has provided insight into the epigenetic regulation of gene expression during EMT.