Pengpeng Liu, Ph.D.
| Instructor (Wolfe Lab) |  |
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| Ph.D.: 2014, Peking University, China | ||
| Postdoctoral research: UMass Chan Medical School | ||
| Office: | UMass Chan Medical School 364 Plantation Street, LRB 670M Worcester, MA 01605 |
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| Phone: | 508-856-3756 | |
| Email: | Pengpeng.Liu2@umassmed.edu | |
Research
My research interests lie in developing and improving genome editing technologies for therapeutic applications. I have developed a variety of enhanced genome editing tools including an improved CRISPR-Cas12a system that facilitates efficient targeted mutagenesis in mammalian cells and zebrafish (Liu et al. Nucleic Acids Res 2019), and an NLS-optimized SpCas9-based prime editor that improves genome editing efficiency in both fluorescent reporter cells and at endogenous loci in cultured cell lines (Liu et al. Nat Commun 2021). Recently, I demonstrated that increasing intracellular dNTP levels improves prime editing efficiency (Liu et al. Nat Biotechnol 2024).