Publications

Conserved motifs on the cytoplasmic face of the protein translocation channel are critical for the transition between resting and active conformations.
Mandon EC, Butova C, Lachapelle A, Gilmore R.
J Biol Chem. 2018 Aug 31;293(35):13662-13672. doi: 10.1074/jbc.RA118.004123. Epub 2018 Jul 9. PMID: 29986881

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum.
Braunger K, Pfeffer S, Shrimal S, Gilmore R, Berninghausen O, Mandon EC, Becker T, Förster F, Beckmann R.
Science. 2018 Apr 13;360(6385):215-219. doi: 10.1126/science.aar7899. Epub 2018 Mar 8. PMID: 29519914 

Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins.
Tripathi A, Mandon EC, Gilmore R, Rapoport TA.
J Biol Chem. 2017 May 12;292(19):8007-8018. doi: 10.1074/jbc.M116.761122. Epub 2017 Mar 12. PMID: 28286332

Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf^_-/- mouse model.
Chapeau EA, Gembarska A, Durand EY, Mandon E, Estadieu C, Romanet V, Wiesmann M, Tiedt R, Lehar J, de Weck A, Rad R, Barys L, Jeay S, Ferretti S, Kauffmann A, Sutter E, Grevot A, Moulin P, Murakami M, Sellers WR, Hofmann F, Jensen MR.
Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3151-3156. doi: 10.1073/pnas.1620262114. Epub 2017 Mar 6. PMID: 28265066

Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia.
Wu SC, Li LS, Kopp N, Montero J, Chapuy B, Yoda A, Christie AL, Liu H, Christodoulou A, van Bodegom D, van der Zwet J, Layer JV, Tivey T, Lane AA, Ryan JA, Ng SY, DeAngelo DJ, Stone RM, Steensma D, Wadleigh M, Harris M, Mandon E, Ebel N, Andraos R, Romanet V, Dölemeyer A, Sterker D, Zender M, Rodig SJ, Murakami M, Hofmann F, Kuo F, Eck MJ, Silverman LB, Sallan SE, Letai A, Baffert F, Vangrevelinghe E, Radimerski T, Gaul C, Weinstock DM.
Cancer Cell. 2015 Jul 13;28(1):29-41. doi: 10.1016/j.ccell.2015.06.005. PMID: 26175414

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.
Meyer SC, Keller MD, Chiu S, Koppikar P, Guryanova OA, Rapaport F, Xu K, Manova K, Pankov D, O'Reilly RJ, Kleppe M, McKenney AS, Shih AH, Shank K, Ahn J, Papalexi E, Spitzer B, Socci N, Viale A, Mandon E, Ebel N, Andraos R, Rubert J, Dammassa E, Romanet V, Dölemeyer A, Zender M, Heinlein M, Rampal R, Weinberg RS, Hoffman R, Sellers WR, Hofmann F, Murakami M, Baffert F, Gaul C, Radimerski T, Levine RL.
Cancer Cell. 2015 Jul 13;28(1):15-28. doi: 10.1016/j.ccell.2015.06.006. PMID: 2617541

Protein translocation across the rough endoplasmic reticulum.
Mandon EC, Trueman SF, Gilmore R.
Cold Spring Harb Perspect Biol. 2013 Feb 1;5(2):a013342. doi: 10.1101/cshperspect.a013342. PMID: 23251026

A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function.
Trueman SF, Mandon EC, Gilmore R.
J Cell Biol. 2012 Dec 10;199(6):907-18. doi: 10.1083/jcb.201207163. PMID: 23229898

Understanding integration of α-helical membrane proteins: the next steps.
Gilmore R, Mandon EC.
Trends Biochem Sci. 2012 Aug;37(8):303-8. doi: 10.1016/j.tibs.2012.05.003. Epub 2012 Jun 29. PMID: 22748693

Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity.
Trueman SF, Mandon EC, Gilmore R.
Mol Biol Cell. 2011 Sep;22(17):2983-93. doi: 10.1091/mbc.E11-01-0070. Epub 2011 Jul 7. PMID: 21737680

Structure of monomeric yeast and mammalian Sec61 complexes interacting with the translating ribosome.
Becker T, Bhushan S, Jarasch A, Armache JP, Funes S, Jossinet F, Gumbart J, Mielke T, Berninghausen O, Schulten K, Westhof E, Gilmore R, Mandon EC, Beckmann R.
Science. 2009 Dec 4;326(5958):1369-73. doi: 10.1126/science.1178535. Epub 2009 Oct 29. PMID: 19933108

Translocation of proteins through the Sec61 and SecYEG channels.
Mandon EC, Trueman SF, Gilmore R.
Curr Opin Cell Biol. 2009 Aug;21(4):501-7. doi: 10.1016/j.ceb.2009.04.010. Epub 2009 May 18. PMID: 19450960

An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation.
Jiang Y, Cheng Z, Mandon EC, Gilmore R.
J Cell Biol. 2008 Mar 24;180(6):1149-61. doi: 10.1083/jcb.200707196. Epub 2008 Mar 17. PMID: 18347066

The tail end of membrane insertion.
Mandon EC, Gilmore R.
Cell. 2007 Mar 23;128(6):1031-2. doi: 10.1016/j.cell.2007.03.001

Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation.
Cheng Z, Jiang Y, Mandon EC, Gilmore R.
J Cell Biol. 2005 Jan 3;168(1):67-77. doi: 10.1083/jcb.200408188. PMID: 15631991

GTPase twins in the SRP family.
Mandon EC, Gilmore R.
Nat Struct Mol Biol. 2004 Feb;11(2):115-6. doi: 10.1038/nsmb0204-115. PMID: 14749771.

Dual recognition of the ribosome and the signal recognition particle by the SRP receptor during protein targeting to the endoplasmic reticulum.
Mandon EC, Jiang Y, Gilmore R.
J Cell Biol. 2003 Aug 18;162(4):575-85. doi: 10.1083/jcb.200303143. Epub 2003 Aug 11. PMID: 12913112

Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties.
Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R.
Mol Cell. 2003 Jul;12(1):101-11. doi: 10.1016/s1097-2765(03)00243-0. PMID: 12887896

Role of Sec61alpha in the regulated transfer of the ribosome-nascent chain complex from the signal recognition particle to the translocation channel.
Song W, Raden D, Mandon EC, Gilmore R.
Cell. 2000 Feb 4;100(3):333-43. doi: 10.1016/s0092-8674(00)80669-8. PMID: 10676815