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Kurt Yilmaz Lab
Biochemistry and Molecular Biotechnology
Research
Research
Viral Proteases
SARS-CoV-2 & Other Coronaviruses
Influenza Antibodies
Type I Diabetes
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Kurt Yilmaz Lab
Home
Research
Viral Proteases
SARS-CoV-2 & Other Coronaviruses
Influenza Antibodies
Type I Diabetes
Cancer & Gene Editing
Publications
The Lab
The PI
Lab Members
Collaborations
Contact
Kurt Yilmaz Lab
Home
Research
Viral Proteases
SARS-CoV-2 & Other Coronaviruses
Influenza Antibodies
Type I Diabetes
Cancer & Gene Editing
Publications
The Lab
The PI
Lab Members
Collaborations
Contact
Publications
Total:
displaying 50 out of
100
results
Direct delivery of Cas-embedded cytosine base editors as ribonucleoprotein complexes for efficient and accurate editing of clinically relevant targets
Monday, December 16, 2024
Author(s):
Jeong Min Lee,Jing Zeng,Pengpeng Liu,My Anh Nguyen,Diego Suchenski Loustaunau,Daniel E Bauer,Nese Kurt Yilmaz,Scot A Wolfe,Celia A Schiffer
Source:
Nucleic acids research
Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance
Saturday, September 28, 2024
Author(s):
Vincent N Azzolino,Ala M Shaqra,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Viruses
Next generation APOBEC3 inhibitors: Optimally designed for potency and nuclease stability
Monday, September 16, 2024
Author(s):
Adam K Hedger,Wazo Myint,Jeong Min Lee,Diego Suchenski-Loustaunau,Vanivilasini Balachandran,Ala M Shaqra,Nese Kurt-Yilmaz,Jonathan K Watts,Hiroshi Matsuo,Celia A Schiffer
Source:
bioRxiv : the preprint server for biology
Enabling equitable and affordable access to novel therapeutics for pandemic preparedness and response via creative intellectual property agreements
Monday, August 26, 2024
Author(s):
Ed J Griffen,Pascale Boulet,ASAP Discovery Center,COVID Moonshot
Source:
Wellcome open research
Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance
Tuesday, March 12, 2024
Author(s):
Julia M Flynn,Sarah N Zvornicanin,Tenzin Tsepal,Ala M Shaqra,Nese Kurt Yilmaz,Weiping Jia,Stephanie Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon
Source:
ACS infectious diseases
Direct delivery of stabilized Cas-embedded base editors achieves efficient and accurate editing of clinically relevant targets
Monday, February 19, 2024
Author(s):
Jeong Min Lee,Jing Zeng,Pengpeng Liu,My Anh Nguyen,Diego Suchenski Loustaunau,Daniel E Bauer,Nese Kurt Yilmaz,Scot A Wolfe,Celia A Schiffer
Source:
bioRxiv : the preprint server for biology
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors
Thursday, November 09, 2023
Author(s):
Melissa L Boby,Daren Fearon,Matteo Ferla,Mihajlo Filep,Lizbé Koekemoer,Matthew C Robinson,COVID Moonshot Consortium‡,John D Chodera,Alpha A Lee,Nir London,Annette von Delft,Frank von Delft,Hagit Achdo...
Source:
Science (New York, N.Y.)
Management of Status Epilepticus by Different Pediatric Departments: Neurology, Intensive Care, and Emergency Medicine
Wednesday, August 30, 2023
Author(s):
Özge Dedeoglu,Halise Akça,Serhat Emeksiz,Ayşe Kartal,Neşe Çıtak Kurt
Source:
European neurology
Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease
Friday, June 30, 2023
Author(s):
Julia M Flynn,Qiu Yu J Huang,Sarah N Zvornicanin,Gila Schneider-Nachum,Ala M Shaqra,Nese Kurt Yilmaz,Stephanie A Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon
Source:
ACS infectious diseases
HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues
Saturday, May 27, 2023
Author(s):
Gordon J Lockbaum,Linah N Rusere,Mina Henes,Klajdi Kosovrasti,Desaboini Nageswara Rao,Ean Spielvogel,Sook-Kyung Lee,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
Source:
European journal of medicinal chemistry
Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses
Thursday, March 30, 2023
Author(s):
Sarah N Zvornicanin,Ala M Shaqra,Qiuyu J Huang,Elizabeth Ornelas,Mallika Moghe,Mark Knapp,Stephanie Moquin,Dustin Dovala,Celia A Schiffer,Nese Kurt Yilmaz
Source:
Viruses
Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance
Wednesday, March 15, 2023
Author(s):
Ean Spielvogel,Sook-Kyung Lee,Shuntai Zhou,Gordon J Lockbaum,Mina Henes,Amy Sondgeroth,Klajdi Kosovrasti,Ellen A Nalivaika,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer,Ronald Swanstrom
Source:
eLife
Allosteric quinoxaline-based inhibitors of the flavivirus NS2B/NS3 protease
Tuesday, November 29, 2022
Author(s):
Jacqueto Zephyr,Desaboini Nageswara Rao,Colby Johnson,Ala M Shaqra,Ellen A Nalivaika,Aria Jordan,Nese Kurt Yilmaz,Akbar Ali,Celia A Schiffer
Source:
Bioorganic chemistry
Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants
Thursday, September 29, 2022
Author(s):
Qi Li,Fiachra Humphries,Roxie C Girardin,Aaron Wallace,Monir Ejemel,Alla Amcheslavsky,Conor T McMahon,Zachary A Schiller,Zepei Ma,John Cruz,Alan P Dupuis,Anne F Payne,Arooma Maryam,Nese Kurt Yilmaz,Ka...
Source:
Frontiers in immunology
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance
Tuesday, June 21, 2022
Author(s):
Ala M Shaqra,Sarah N Zvornicanin,Qiu Yu J Huang,Gordon J Lockbaum,Mark Knapp,Laura Tandeske,David T Bakan,Julia Flynn,Daniel N A Bolon,Stephanie Moquin,Dustin Dovala,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Nature communications
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
Monday, June 20, 2022
Author(s):
Julia M Flynn,Neha Samant,Gily Schneider-Nachum,David T Barkan,Nese Kurt Yilmaz,Celia A Schiffer,Stephanie A Moquin,Dustin Dovala,Daniel N A Bolon
Source:
eLife
Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance
Sunday, February 20, 2022
Author(s):
Jacqueto Zephyr,Desaboini Nageswara Rao,Sang V Vo,Mina Henes,Klajdi Kosovrasti,Ashley N Matthew,Adam K Hedger,Jennifer Timm,Elise T Chan,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of molecular biology
Viral proteases: Structure, mechanism and inhibition
Saturday, December 04, 2021
Author(s):
Jacqueto Zephyr,Nese Kurt Yilmaz,Celia A Schiffer
Source:
The Enzymes
Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode
Friday, September 10, 2021
Author(s):
Gordon J Lockbaum,Mina Henes,Jeong Min Lee,Jennifer Timm,Ellen A Nalivaika,Paul R Thompson,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Biochemistry
Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants
Wednesday, August 18, 2021
Author(s):
Desaboini Nageswara Rao,Jacqueto Zephyr,Mina Henes,Elise T Chan,Ashley N Matthew,Adam K Hedger,Hasahn L Conway,Mohsan Saeed,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt Yilmaz,Celia A Schi...
Source:
Journal of medicinal chemistry
Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s
Friday, June 25, 2021
Author(s):
Shurong Hou,Jeong Min Lee,Wazo Myint,Hiroshi Matsuo,Nese Kurt Yilmaz,Celia A Schiffer
Source:
The Journal of biological chemistry
Deciphering Antifungal Drug Resistance in Pneumocystis jirovecii DHFR with Molecular Dynamics and Machine Learning
Thursday, June 17, 2021
Author(s):
Florian Leidner,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of chemical information and modeling
Deciphering Complex Mechanisms of Resistance and Loss of Potency through Coupled Molecular Dynamics and Machine Learning
Tuesday, March 30, 2021
Author(s):
Florian Leidner,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of chemical theory and computation
Introduction: Drug Resistance
Wednesday, March 24, 2021
Author(s):
Nese Kurt Yilmaz,Celia A Schiffer
Source:
Chemical reviews
Inhibiting HTLV-1 Protease: A Viable Antiviral Target
Tuesday, February 23, 2021
Author(s):
Gordon J Lockbaum,Mina Henes,Nathaniel Talledge,Linah N Rusere,Klajdi Kosovrasti,Ellen A Nalivaika,Mohan Somasundaran,Akbar Ali,Louis M Mansky,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS chemical biology
Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188
Thursday, January 28, 2021
Author(s):
Gordon J Lockbaum,Archie C Reyes,Jeong Min Lee,Ronak Tilvawala,Ellen A Nalivaika,Akbar Ali,Nese Kurt Yilmaz,Paul R Thompson,Celia A Schiffer
Source:
Viruses
Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond
Thursday, January 07, 2021
Author(s):
Ashley N Matthew,Florian Leidner,Gordon J Lockbaum,Mina Henes,Jacqueto Zephyr,Shurong Hou,Desaboini Nageswara Rao,Jennifer Timm,Linah N Rusere,Debra A Ragland,Janet L Paulsen,Kristina Prachanronarong,...
Source:
Chemical reviews
Crystal Structure of a Soluble APOBEC3G Variant Suggests ssDNA to Bind in a Channel that Extends between the Two Domains
Sunday, October 25, 2020
Author(s):
Atanu Maiti,Wazo Myint,Krista A Delviks-Frankenberry,Shurong Hou,Tapan Kanai,Vanivilasini Balachandran,Christina Sierra Rodriguez,Rashmi Tripathi,Nese Kurt Yilmaz,Vinay K Pathak,Celia A Schiffer,Hiros...
Source:
Journal of molecular biology
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction
Sunday, August 23, 2020
Author(s):
Monir Ejemel,Qi Li,Shurong Hou,Zachary A Schiller,Julia A Tree,Aaron Wallace,Alla Amcheslavsky,Nese Kurt Yilmaz,Karen R Buttigieg,Michael J Elmore,Kerry Godwin,Naomi Coombes,Jacqueline R Toomey,Ryan S...
Source:
Nature communications
Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes
Wednesday, July 29, 2020
Author(s):
Erica P Cai,Yuki Ishikawa,Wei Zhang,Nayara C Leite,Jian Li,Shurong Hou,Badr Kiaf,Jennifer Hollister-Lock,Nese Kurt Yilmaz,Celia A Schiffer,Douglas A Melton,Stephan Kissler,Peng Yi
Source:
Nature metabolism
Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere
Friday, July 17, 2020
Author(s):
Linah N Rusere,Gordon J Lockbaum,Mina Henes,Sook-Kyung Lee,Ean Spielvogel,Desaboini Nageswara Rao,Klajdi Kosovrasti,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
Source:
Journal of medicinal chemistry
IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity
Tuesday, June 09, 2020
Author(s):
Monir Ejemel,Qi Li,Shurong Hou,Zachary A Schiller,Aaron L Wallace,Alla Amcheslavsky,Nese Kurt Yilmaz,Jacqueline R Toomey,Ryan Schneider,Brianna J Close,Da-Yuan Chen,Hasahn L Conway,Saeed Mohsan,Lisa A...
Source:
bioRxiv : the preprint server for biology
Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors
Friday, April 03, 2020
Author(s):
Ashley N Matthew,Jacqueto Zephyr,Desaboini Nageswara Rao,Mina Henes,Wasih Kamran,Klajdi Kosovrasti,Adam K Hedger,Gordon J Lockbaum,Jennifer Timm,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
Source:
mBio
Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures
Friday, March 06, 2020
Author(s):
Gordon J Lockbaum,Florian Leidner,William E Royer,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Acta crystallographica. Section D, Structural biology
Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir
Tuesday, December 24, 2019
Author(s):
Jennifer Timm,Klajdi Kosovrasti,Mina Henes,Florian Leidner,Shurong Hou,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS chemical biology
Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA
Tuesday, August 20, 2019
Author(s):
William C Solomon,Wazo Myint,Shurong Hou,Tapan Kanai,Rashmi Tripathi,Nese Kurt Yilmaz,Celia A Schiffer,Hiroshi Matsuo
Source:
Nucleic acids research
HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope
Wednesday, August 07, 2019
Author(s):
Linah N Rusere,Gordon J Lockbaum,Sook-Kyung Lee,Mina Henes,Klajdi Kosovrasti,Ean Spielvogel,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
Source:
Journal of medicinal chemistry
Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance
Wednesday, August 07, 2019
Author(s):
Mina Henes,Klajdi Kosovrasti,Gordon J Lockbaum,Florian Leidner,Gily S Nachum,Ellen A Nalivaika,Daniel N A Bolon,Nese Kurt Yilmaz,Celia A Schiffer,Troy W Whitfield
Source:
Biochemistry
Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints
Tuesday, August 06, 2019
Author(s):
Florian Leidner,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of chemical information and modeling
Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance
Wednesday, July 31, 2019
Author(s):
Mina Henes,Gordon J Lockbaum,Klajdi Kosovrasti,Florian Leidner,Gily S Nachum,Ellen A Nalivaika,Sook-Kyung Lee,Ean Spielvogel,Shuntai Zhou,Ronald Swanstrom,Daniel N A Bolon,Nese Kurt Yilmaz,Celia A Sch...
Source:
ACS chemical biology
NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations
Friday, June 28, 2019
Author(s):
Rieko Ishima,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of biomolecular NMR
Correction to Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease
Wednesday, April 17, 2019
Author(s):
Gordon J Lockbaum,Florian Leidner,Linah N Rusere,Mina Henes,Klajdi Kosovrasti,Gily S Nachum,Ellen A Nalivaika,Daniel N A Bolon,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS infectious diseases
Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease
Friday, December 14, 2018
Author(s):
Gordon J Lockbaum,Florian Leidner,Linah N Rusere,Mina Henes,Klajdi Kosovrasti,Gily S Nachum,Ellen A Nalivaika,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS infectious diseases
Structural Analysis of the Active Site and DNA Binding of Human Cytidine Deaminase APOBEC3B
Wednesday, November 21, 2018
Author(s):
Shurong Hou,Tania V Silvas,Florian Leidner,Ellen A Nalivaika,Hiroshi Matsuo,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of chemical theory and computation
HIV-1 Protease Uses Bi-Specific S2/S2' Subsites to Optimize Cleavage of Two Classes of Target Sites
Sunday, November 11, 2018
Author(s):
Marc Potempa,Sook-Kyung Lee,Nese Kurt Yilmaz,Ellen A Nalivaika,Amy Rogers,Ean Spielvogel,Charles W Carter,Celia A Schiffer,Ronald Swanstrom
Source:
Journal of molecular biology
Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody
Friday, November 02, 2018
Author(s):
Kristina L Prachanronarong,Aneth S Canale,Ping Liu,Mohan Somasundaran,Shurong Hou,Yu-Ping Poh,Thomas Han,Quan Zhu,Nicholas Renzette,Konstantin B Zeldovich,Timothy F Kowalik,Nese Kurt-Yilmaz,Jeffrey D ...
Source:
Journal of virology
Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease
Tuesday, August 28, 2018
Author(s):
Ashley N Matthew,Florian Leidner,Alicia Newton,Christos J Petropoulos,Wei Huang,Akbar Ali,Nese KurtYilmaz,Celia A Schiffer
Source:
Structure (London, England : 1993)
Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants
Tuesday, July 24, 2018
Author(s):
Linah N Rusere,Ashley N Matthew,Gordon J Lockbaum,Muhammad Jahangir,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
Source:
ACS medicinal chemistry letters
T cell epitope engineering: an avian H7N9 influenza vaccine strategy for pandemic preparedness and response
Wednesday, July 18, 2018
Author(s):
Leonard Moise,Bethany M Biron,Christine M Boyle,Nese Kurt Yilmaz,Hyesun Jang,Celia Schiffer,Ted M Ross,William D Martin,Anne S De Groot
Source:
Human vaccines & immunotherapeutics
Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions
Wednesday, May 16, 2018
Author(s):
Tania V Silvas,Shurong Hou,Wazo Myint,Ellen Nalivaika,Mohan Somasundaran,Brian A Kelch,Hiroshi Matsuo,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Scientific reports
Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease
Saturday, March 24, 2018
Author(s):
Florian Leidner,Nese Kurt Yilmaz,Janet Paulsen,Yves A Muller,Celia A Schiffer
Source:
Journal of chemical theory and computation
Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance
Tuesday, February 20, 2018
Author(s):
Shahid N Khan,John D Persons,Janet L Paulsen,Michel Guerrero,Celia A Schiffer,Nese Kurt-Yilmaz,Rieko Ishima
Source:
Biochemistry
Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope
Saturday, December 16, 2017
Author(s):
Yuval Avnir,Kristina L Prachanronarong,Zhen Zhang,Shurong Hou,Eric C Peterson,Jianhua Sui,Hatem Zayed,Vinodh B Kurella,Andrew T McGuire,Leonidas Stamatatos,Brendan J Hilbert,Markus-Frederik Bohn,Timot...
Source:
Cell reports
Mavyret: A Pan-Genotypic Combination Therapy for the Treatment of Hepatitis C InfectionPublished as part of the Biochemistry series "Biochemistry to Bedside"
Saturday, December 02, 2017
Author(s):
Ashley N Matthew,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Biochemistry
Elucidating the Interdependence of Drug Resistance from Combinations of Mutations
Saturday, September 16, 2017
Author(s):
Debra A Ragland,Troy W Whitfield,Sook-Kyung Lee,Ronald Swanstrom,Konstantin B Zeldovich,Nese Kurt-Yilmaz,Celia A Schiffer
Source:
Journal of chemical theory and computation
Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants
Friday, June 09, 2017
Author(s):
Ashley N Matthew,Jacqueto Zephyr,Caitlin J Hill,Muhammad Jahangir,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt-Yilmaz,Celia A Schiffer,Akbar Ali
Source:
Journal of medicinal chemistry
Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity
Saturday, April 29, 2017
Author(s):
Takahide Kouno,Tania V Silvas,Brendan J Hilbert,Shivender M D Shandilya,Markus F Bohn,Brian A Kelch,William E Royer,Mohan Somasundaran,Nese Kurt Yilmaz,Hiroshi Matsuo,Celia A Schiffer
Source:
Nature communications
Interdependence of Inhibitor Recognition in HIV-1 Protease
Friday, March 31, 2017
Author(s):
Janet L Paulsen,Florian Leidner,Debra A Ragland,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of chemical theory and computation
Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side
Friday, March 17, 2017
Author(s):
Kuan-Hung Lin,Akbar Ali,Linah Rusere,Djade I Soumana,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of virology
Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase
Wednesday, December 14, 2016
Author(s):
Kristina L Prachanronarong,Ayşegül Özen,Kelly M Thayer,L Safak Yilmaz,Konstantin B Zeldovich,Daniel N Bolon,Timothy F Kowalik,Jeffrey D Jensen,Robert W Finberg,Jennifer P Wang,Nese Kurt-Yilmaz,Celia A...
Source:
Journal of chemical theory and computation
Structural and molecular analysis of a protective epitope of Lyme disease antigen OspA and antibody interactions
Saturday, November 19, 2016
Author(s):
Shivender Shandilya,Nese Kurt Yilmaz,Andrew Sadowski,Ejemel Monir,Zachary A Schiller,William D Thomas,Mark S Klempner,Celia A Schiffer,Yang Wang
Source:
Journal of molecular recognition : JMR
Dengue Protease Substrate Recognition: Binding of the Prime Side
Friday, September 23, 2016
Author(s):
Kuan-Hung Lin,Ellen A Nalivaika,Kristina L Prachanronarong,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS infectious diseases
Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease
Friday, August 12, 2016
Author(s):
Djadé I Soumana,Nese Kurt Yilmaz,Akbar Ali,Kristina L Prachanronarong,Celia A Schiffer
Source:
Journal of the American Chemical Society
Improving Viral Protease Inhibitors to Counter Drug Resistance
Wednesday, April 20, 2016
Author(s):
Nese Kurt Yilmaz,Ronald Swanstrom,Celia A Schiffer
Source:
Trends in microbiology
Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172
Sunday, December 20, 2015
Author(s):
Djadé I Soumana,Nese Kurt Yilmaz,Kristina L Prachanronarong,Cihan Aydin,Akbar Ali,Celia A Schiffer
Source:
ACS chemical biology
The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization
Tuesday, April 28, 2015
Author(s):
Markus-Frederik Bohn,Shivender M D Shandilya,Tania V Silvas,Ellen A Nalivaika,Takahide Kouno,Brian A Kelch,Sean P Ryder,Nese Kurt-Yilmaz,Mohan Somasundaran,Celia A Schiffer
Source:
Structure (London, England : 1993)
Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease
Friday, October 31, 2014
Author(s):
Ayşegül Özen,Kuan-Hung Lin,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Proceedings of the National Academy of Sciences of the United States of America
Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease
Wednesday, August 20, 2014
Author(s):
Yufeng Cai,Wazo Myint,Janet L Paulsen,Celia A Schiffer,Rieko Ishima,Nese Kurt Yilmaz
Source:
Journal of chemical theory and computation
Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease
Wednesday, August 06, 2014
Author(s):
Debra A Ragland,Ellen A Nalivaika,Madhavi N L Nalam,Kristina L Prachanronarong,Hong Cao,Rajintha M Bandaranayake,Yufeng Cai,Nese Kurt-Yilmaz,Celia A Schiffer
Source:
Journal of the American Chemical Society
Burial of nonpolar surface area and thermodynamic stabilization of globins as a function of chain elongation
Wednesday, April 23, 2014
Author(s):
Theodore S Jennaro,Matthew R Beaty,Neşe Kurt-Yilmaz,Benjamin L Luskin,Silvia Cavagnero
Source:
Proteins
HIV-1 protease-substrate coevolution in nelfinavir resistance
Friday, April 11, 2014
Author(s):
Madhavi Kolli,Ayşegül Ozen,Nese Kurt-Yilmaz,Celia A Schiffer
Source:
Journal of virology
Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance
Tuesday, September 10, 2013
Author(s):
Madhavi N L Nalam,Akbar Ali,G S Kiran Kumar Reddy,Hong Cao,Saima G Anjum,Michael D Altman,Nese Kurt Yilmaz,Bruce Tidor,Tariq M Rana,Celia A Schiffer
Source:
Chemistry & biology
Sub-millisecond chain collapse of the Escherichia coli globin ApoHmpH
Wednesday, June 12, 2013
Author(s):
Li Zhu,Neşe Kurt,Jennifer Choi,Lisa J Lapidus,Silvia Cavagnero
Source:
The journal of physical chemistry. B
Electrostatic effect of the ribosomal surface on nascent polypeptide dynamics
Saturday, March 23, 2013
Author(s):
Anders M Knight,Peter H Culviner,Neşe Kurt-Yilmaz,Taisong Zou,S Banu Ozkan,Silvia Cavagnero
Source:
ACS chemical biology
Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50
Friday, February 01, 2013
Author(s):
Seema Mittal,Rajinthna M Bandaranayake,Nancy M King,Moses Prabu-Jeyabalan,Madhavi N L Nalam,Ellen A Nalivaika,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of virology
Cooperative effects of drug-resistance mutations in the flap region of HIV-1 protease
Friday, December 21, 2012
Author(s):
Jennifer E Foulkes-Murzycki,Christina Rosi,Nese Kurt Yilmaz,Robert W Shafer,Celia A Schiffer
Source:
ACS chemical biology
Differential Flap Dynamics in Wild-type and a Drug Resistant Variant of HIV-1 Protease Revealed by Molecular Dynamics and NMR Relaxation
Tuesday, November 13, 2012
Author(s):
Yufeng Cai,Nese Kurt Yilmaz,Wazo Myint,Rieko Ishima,Celia A Schiffer
Source:
Journal of chemical theory and computation
Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease
Thursday, June 21, 2012
Author(s):
Nancy M King,Moses Prabu-Jeyabalan,Rajintha M Bandaranayake,Madhavi N L Nalam,Ellen A Nalivaika,Ayşegül Özen,Türkan Haliloğlu,Neşe Kurt Yilmaz,Celia A Schiffer
Source:
ACS chemical biology
High-resolution conformation and backbone dynamics of a soluble aggregate of apomyoglobin119
Wednesday, February 02, 2011
Author(s):
Senapathy Rajagopalan,Neşe Kurt,Silvia Cavagnero
Source:
Biophysical journal
Effects of epilepsy and antiepileptic drugs on nitric oxide, lipid peroxidation and xanthine oxidase system in children with idiopathic epilepsy
Tuesday, November 30, 2010
Author(s):
Ebru Arhan,Ayse Serdaroglu,Bahadır Ozturk,H Serdar Ozturk,Aysima Ozcelik,Nese Kurt,Ebru Kutsal,Neriman Sevinc
Source:
Seizure
Neonate with meroacrania: radiological findings and review of the literature
Friday, November 13, 2009
Author(s):
Hanefi Yildirim,Mustafa Koç,Neşe Kurt,Hakan Artaş,Denizmen Aygün
Source:
Diagnostic and interventional radiology (Ankara, Turkey)
Use of phototherapy for neonatal hyperbilirubinemia affects cytokine production and lymphocyte subsets
Friday, November 14, 2008
Author(s):
Abdullah Kurt,A Denizmen Aygun,A Nese Citak Kurt,Ahmet Godekmerdan,Saadet Akarsu,Erdal Yilmaz
Source:
Neonatology
Nonrandom distribution of intramolecular contacts in native single-domain proteins
Friday, October 03, 2008
Author(s):
Bryan C Mounce,Neşe Kurt,Paul A Ellison,Silvia Cavagnero
Source:
Proteins
A prospective study of etiology of childhood acute bacterial meningitis, Turkey
Saturday, July 05, 2008
Author(s):
Mehmet Ceyhan,Inci Yildirim,Paul Balmer,Ray Borrow,Bunyamin Dikici,Mehmet Turgut,Nese Kurt,Aysel Aydogan,Cigdem Ecevit,Yasar Anlar,Ozlem Gulumser,Gonul Tanir,Nuran Salman,Nezahat Gurler,Nevin Hatipogl...
Source:
Emerging infectious diseases
Residue-specific contact order and contact breadth in single-domain proteins: implications for folding as a function of chain elongation
Tuesday, May 13, 2008
Author(s):
Neşe Kurt,Bryan C Mounce,Paul A Ellison,Silvia Cavagnero
Source:
Biotechnology progress
The levels of Ghrelin, TNF-alpha, and IL-6 in children with cyanotic and acyanotic congenital heart disease
Saturday, February 16, 2008
Author(s):
Erdal Yilmaz,Bilal Ustundag,Yasar Sen,Saadet Akarsu,A Nese citak Kurt,Yasar Dogan
Source:
Mediators of inflammation
Serum IL-1beta, IL-6, IL-8, and TNF-alpha levels in early diagnosis and management of neonatal sepsis
Saturday, February 16, 2008
Author(s):
A Nese Citak Kurt,A Denizmen Aygun,Ahmet Godekmerdan,Abdullah Kurt,Yasar Dogan,Erdal Yilmaz
Source:
Mediators of inflammation
Nonnative helical motif in a chaperone-bound protein fragment
Tuesday, January 15, 2008
Author(s):
Neşe Kurt,Silvia Cavagnero
Source:
Biophysical journal
Thermodynamic and kinetic characterization of apoHmpH, a fast-folding bacterial globin
Saturday, January 12, 2008
Author(s):
Ye-Jin Eun,Neşe Kurt,Ashok Sekhar,Silvia Cavagnero
Source:
Journal of molecular biology
Age-specific seroprevalence of serogroup C meningococcal serum bactericidal antibody activity and serogroup A, C, W135 and Y-specific IgG concentrations in the Turkish population during 2005
Tuesday, August 21, 2007
Author(s):
Mehmet Ceyhan,Inci Yildirim,Paul Balmer,Christine Riley,Gouri Laher,Nick Andrews,Ray Borrow,Nese Kurt,Mehmet Turgut,Aysel Aydogan,Cigdem Ecevit,Gulnar Uysal,Viola Schultze
Source:
Vaccine
Serum endothelin-1 and transforming growth factor-beta levels in the newborns with respiratory distress
Friday, March 30, 2007
Author(s):
Derya Benzer,A Denizmen Aygun,Ahmet Godekmerdan,A Nese Citak Kurt,Saadet Akarsu,Erdal Yilmaz
Source:
Mediators of inflammation
Malignant infantile osteopetrosis: a rare cause of neonatal hypocalcemia
Saturday, January 27, 2007
Author(s):
Abdullah Kurt,Yasar Sen,Ozlem Elkiran,Saadet Akarsu,A Nese Citak Kurt,A Denizmen Aygun
Source:
Journal of pediatric endocrinology & metabolism : JPEM
Binding specificity of an alpha-helical protein sequence to a full-length Hsp70 chaperone and its minimal substrate-binding domain
Thursday, November 16, 2006
Author(s):
Carolina A Vega,Neşe Kurt,Zhongjing Chen,Stefan Rüdiger,Silvia Cavagnero
Source:
Biochemistry
Secondary structure mapping of DnaK-bound protein fragments: chain helicity and local helix unwinding at the binding site
Wednesday, October 04, 2006
Author(s):
Zhongjing Chen,Nese Kurt,Senapathy Rajagopalan,Silvia Cavagnero
Source:
Biochemistry
Effect of hsp70 chaperone on the folding and misfolding of polypeptides modeling an elongating protein chain
Tuesday, November 29, 2005
Author(s):
Neşe Kurt,Senapathy Rajagopalan,Silvia Cavagnero
Source:
Journal of molecular biology
The burial of solvent-accessible surface area is a predictor of polypeptide folding and misfolding as a function of chain elongation
Thursday, November 10, 2005
Author(s):
Neşe Kurt,Silvia Cavagnero
Source:
Journal of the American Chemical Society
Structural characterization of apomyoglobin self-associated species in aqueous buffer and urea solution
Tuesday, October 11, 2005
Author(s):
Charles Chow,Nese Kurt,Regina M Murphy,Silvia Cavagnero
Source:
Biophysical journal
The differential diagnostic values of cytokine levels in pleural effusions
Thursday, March 17, 2005
Author(s):
Saadet Akarsu,A Nese Citak Kurt,Yasar Dogan,Erdal Yilmaz,Ahmet Godekmerdan,A Denizmen Aygun
Source:
Mediators of inflammation
Bilateral symmetrical hypodensities in the thalamus in a child with severe hypernatraemia
Saturday, March 12, 2005
Author(s):
Huseyin Ozdemir,Nimet Kabakus,A Nese Cýtak Kurt,Hakan Artas
Source:
Pediatric radiology
Antibiotic resistance of bacterial agents isolated in a neonatal intensive care unit in eastern Turkey
Tuesday, April 20, 2004
Author(s):
Erdal Taskin,Mehmet Kilic,A Denizmen Aygun,Saadet Akarsu,A Neşe Kurt
Source:
Journal of tropical pediatrics
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