Nonsense Suppression

Wu, C., Iyer, S., Wolfe, S., and Jacobson, A. Functional restoration of mouse Nf1 nonsense alleles in differentiated cultured neurons. J. Hum. Genet. 67: 661-668, 2022.

Mangkalaphiban, K., He, F., Ganesan, R., Wu, C., Baker, R., and Jacobson, A. Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae. PLoS Genetics 17: e1009538, 2021.

Mangkalaphiban, K., He, F., Ganesan, R., Wu, C., Baker, R., and Jacobson, A. Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae. bioRxiv 2020.12.15.422930; doi: https://doi.org/10.1101/2020.12.15.422930.

Wu, C., Roy, B., He, F., Yan, K., Jacobson, A. Poly(A)-binding protein regulates the efficiency of translation termination. Cell Reports 33: 108399, 2020.

Roy, B., Friesen, W.J., Tomizawa, Y., Leszyk, J.D., Zhuo, J., Johnson, B., Dakka, J., Trotta, C.R., Xue, X., Mutyam, V., Keeling, K., Mobley, J., Rowe, S.M., Bedwell, D.M., Welch, E.M., and Jacobson, A. Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression. Proc. Natl. Acad. Sci. USA 113: 12508-12513, 2016.

Roy, B., Leszyk, J., Mangus, D.A., and Jacobson, A.  Nonsense suppression by near cognate tRNAs employs alternative base-pairing at codon positions 1 and 3. Proc. Natl. Acad. Sci. USA 112: 3038-3043, 2015.

Johansson, M.J.O. and Jacobson, A. Nonsense-mediated mRNA decay maintains translational fidelity by limiting magnesium uptake. Genes & Devel. 24: 1491-1495, 2010.

Welch, E.M., Barton, E.R., Zhuo, J., Tomizawa, Y, Friesen, W.J., Trifillis, P., Paushkin, S.,  Patel, M., Trotta, C.R., Hwang, S., Wilde, R.G., Karp, G., Takasugi, J., Chen, G., Jones, S., Ren, H., Moon, Y.-C., Corson, D., Turpoff, A.A., Campbell, J.A., Conn, M.M., Khan, A.,  Almstead, N.G., Hedrick, J., Molin, A., Risher, N., Weetall, M., Yeh, S., Branstrom, A.A.,  Colacino, J.M., Babiak, J., Ju, W.D., Hirawat, S., Northcutt, V.J., Miller, L.L., Spatrick, P., He, F., Kawana, M., Feng, H., Jacobson, A., Peltz, S.W., & Sweeney, H.L. PTC124 targets genetic disorders caused by nonsense mutations. Nature 447: 87-91, 2007.

Maderazo, A.B., He, F., Mangus, D.A., and Jacobson, A. Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p. Mol. Cell. Biol. 20: 4591-4603, 2000.