Program Contacts
Phone: 7744553694
Email: kristen.yanick@umassmed.edu
Robert C. Brewster, PhD
Associate Professor, Department of Systems Biology and Department of Microbiology and Physiological Systems
Dissecting and Understanding the Implications of Resource Sharing to Cellular Decision Making
My group studies transcriptional regulation in bacteria through a combination of theory, using molecularly detailed statistical mechanics models to produce quantitative predictions, and the tools of modern synthetic biology to design and test these predictions using a wide range of microscopy techniques. In particular, I am interested in understanding how the interconnected environment of the cell, where most regulatory players (transcription factor proteins, regulatory RNAs, etc.) act on dozens or even hundreds of different genes, can influence the special and temporal patterns of gene expression
Marian Walhout, PhD
Department of Systems Biology Chair, Maroun Semaan Chair in Biomedical Research, Professor Department of Systems Biology, Professor Program in Molecular Medicine
Understanding the Interplay between Gene Regulatory and Metabolic Networks
We use a variety of experimental and computational systems biology approaches to map and characterize gene regulatory networks and to understand how regulatory circuitry controls animal development, function, and homeostasis. Ultimately, we aim to understand how dysfunctional networks affect or cause diseases like diabetes, obesity and cancer.