Systems, Computational, and Quantitative Biology Courses

This course will help prospective scientists in the biological and medical sciences communicate their work effectively, in writing, graphics, and oral presentations. The course teaches how to prepare a research paper using words, statistics, and figures; how to present science to a lay audience; how to write a grant proposal; and how to present orally to scientific peers.

Credits: 2

Prerequisite(s): None

Fulfills an elective requirement: No

Course Directors: Jill Zitzewitz, Daryl Bosco, and Nese Kurt Yilmaz

Semester Offered: Fall 

Last Taught: Fall 2024

This problem-based course provides learning opportunities through exploration of multidisciplinary areas of contemporary biomedical research, and creates a forum for practice in the skills required for research.

Credits: 6

Prerequisite(s): Matriculation in the PhD Program

Fulfills an elective requirement: No

Course Directors: Jill Zitzewitz, Neal Silverman, Elizabeth Shank

Semester Offered: Fall

Last Taught: Fall 2024

This course covers several important areas of modern bioinformatics and computational biology. The course is aimed not only at students specializing in bioinformatics, but also general biology students who would like to utilize bioinformatics tools in their daily research. The course will begin with an overview of modern sources of bioinformatics data, especially high-throughput sequencing data (RNA-seq, ChIP-seq, DNase-seq, ATAC-seq, Whole genome bisulfite sequencing, etc.), followed by a thorough presentation of an extensive set of statistical learning and machine learning algorithms and their application to analyzing biological data. The course will include 10 lectures each with a homework set, followed by individual or group projects, presented in lieu of the final exam. 

Credits: 2

Prerequisite(s): Familiarity with at least one programming language (e.g. Python, MatLab, R, etc.)

Fulfills an elective requirement: Yes

Course Director: Zhiping Weng

Semester Offered: Fall, Even Years

Last Taught: Fall 2024

This course examines topics across four short modules within the broader scope of systems biology. These modules are Gene Regulation, Network Biology, Genome Organization, and Mathematical and Quantitative Methods. In addition, this course has a hands-on component that teaches programming in Python to analyze data and generate insights through computational approaches. No prior knowledge of computation is assumed, and beginners are encouraged to enroll.

Credits: 3

Prerequisite(s): BBS 614 or BBS 748 (non-degree students) or course equivalent or coordinator's approval.

Fulfills an elective requirement: Yes

Course Director: Hyun Youk, Manuel Garber

Semester Offered: Spring

Last Taught: Spring 2024

Research rotations are defined periods of research experience under the direction of a faculty member. They are intended to familiarize the student with concepts and techniques in several areas of research and to assist the student in evaluating research laboratories and projects that might be developed into a dissertation project. The student will participate in an ongoing research project; gain familiarity with concepts underlying the research; acquire a working knowledge of techniques used in the research; and write a report and present an oral summary of the results of the research.

In the summer term, only MD/PhD students may register.

Credits: 2-5

Fulfills an elective requirement: No

Course Director: Varies

Semester Offered: Fall, Spring, Summer

Last Taught: Taught every Fall, Spring, and Summer

Summer Research – Year 1 is for first year BBS students.  Expectations are for students to (1) formulate initial hypotheses and/or goals, (2) design and begin to execute research plans, (3) Critically read and evaluate relevant literature.

Credits: 6

Fulfills an elective requirement: No

Course Director: Varies

Semester Offered: Summer

Last Taught: Taught every Summer

Students are required to register for this course in the fall semester of the academic year in which they are to pass their Qualifying Examination.

Credits: 1

Fulfills an elective requirement: No

Course Director: Mary Ellen Lane

Semester Offered: Fall

Last Taught: Taught every year 

All graduate students are required to have at least one Thesis Research Advisory Committee (TRAC) meeting each academic year. After passing their Qualifying Examination and selection of their TRAC, students are required to register for this course each fall semester until their Dissertation Advisory Committee is formed.

MD/PhD Goals: 1) To periodically review progress along thesis research project advised by content experts 2) To provide guidance for establishing a thesis research project consistent with the MD/PhD Program goals

MD/PhD Curricular Expectations: Two Thesis Research Advisory Committee (TRAC) meeting each academic year as define by the Professionalism Benchmark Checklist

Credits: 1

Fulfills an elective requirement: No

Course Director: Mary Ellen Lane

Semester Offered: Fall

Last Taught: Taught every year

This course is for students who have selected a program and thesis advisor but who have not yet passed the Qualifying Examination. 

Credits: 9

Fulfills an elective requirement: No

Course Director: Student's thesis advisor

Semester Offered: Fall, Spring, Summer

Last Taught: Taught every semester

Students register for Thesis Research fall term of year three of the program (MD/PhD Students: Fall term of year four in the program), after passing the Qualifying Exam.

Credits: 12

Fulfills an elective requirement: No

Course Director: Student's thesis advisor

Semester Offered: Fall, Spring, Summer

Last Taught: Taught every semester

Students register for Graduate Research fall term of year four (MD/PhD Students: Fall term of year five+) in the PhD Program and will continue to register each semester until they complete all remaining requirements.

Credits: 0

Fulfills an elective requirement: No

Course Director: Student's thesis advisor

Semester Offered: Fall, Spring, Summer

Last Taught: Taught every semester

This course provides students opportunities to recognize and solve ethical problems in the responsible conduct of research. Major NIH required topics include those relevant for graduate students at this stage of training.

Credits: 0.5

Fulfills an elective requirement: No

Course Director: Anthony Imbalzano and Kate Lapane

Semester Offered: Fall

Last Taught: Fall 2024

This course provides students opportunities to recognize and solve ethical problems in the responsible conduct of research. Major NIH required topics include those relevant for graduate students at this stage of training.

Credits: 1

Fulfills an elective requirement: No

Course Director: Anthony Imbalzano and Kate Lapane

Semester Offered: Fall

Last Taught: Fall 2024