Welcome to the Silverman Lab

Our lab is a part of the Division of Infectious Diseases and Immunology in the Department of Medicine and the Program in Innate Immunity, an interdisciplinary and interdepartmental group of investigators, who are focused on discovering the underlying mechanisms that drive immune defenses and inflammation in both health and disease.

Research focus: innate immune recognition and signal transduction in flies and mammals

• How bacteria, viruses and parasites are recognized by innate immune receptors
• Molecular and biochemical mechanisms used by both the host and microbe to respond to infection
• The role of peptidoglycan sensing in inflammatory responses and diseases

Representative publications

• Bharadwaj R, Lusi CF, Mashayekh S, Nagar A, Subbarao M, Kane GI, Wodzanowski KA, Brown AR, Okuda K, Monahan A, Paik D, Nandy A, Anonick MV, Goldman WE, Kanneganti TD, Orzalli MH, Grimes CL, Atukorale PU, Silverman N. Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity. Immunity. 2023 May 9;56(5):998-1012.e8.
  
  
• Lee S, Jun YW, Linares GR, Butler B, Yuva-Adyemir Y, Moore J, Krishnan G, Ruiz-Juarez B, Santana M, Pons M, Silverman N, Weng Z, Ichida JK, Gao FB. Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD. Neuron. 2023 Mar 10:S0896-6273(23)00133-2.
  
  
• Pereira M, Durso DF, Bryant CE, Kurt-Jones EA, Silverman N, Golenbock DT, Gazzinelli RT. The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways. Cell Rep. 2022 Aug 16;40(7):111225.
  
  
• Okuda K, Silva Costa Franco M, Yasunaga A, Gazzinelli R, Rabinovitch M, Cherry S, Silverman N. Leishmania amazonensis sabotages host cell SUMOylation for intracellular survival. iScience, Volume 25, Issue 9, 2022,104909. 

More Publications

Join our lab

We are currently recruiting for a post-doctoral position in our lab. Please contact Dr. Silverman directly if you are interested.