Our Research
Our research focuses on complex diseases that affect the skin and other organs including autoimmunity and cancer. We are interested in understanding how autoimmunity occurs, including triggers and immunopathogenesis, and what we can do to stop it through development of treatment options. We are also interested in understanding how to tweak the adaptive immune system to recognize cancers for immunotherapy. We use several different models to study pathology, with an emphasis on immune cell migration and function in the skin, and cross-talk between the immune system and the target tissue.
Disease areas we are currently investigating with selected publications & published abstracts:
Cutaneous Lupus Erythematosus (you can read more about our work, including our blog, here)
- Th2 to Th1 Transition Is Required for Induction of Skin Lesions in an Inducible and Recurrent Murine Model of Cutaneous Lupus-Like Inflammation
- Shared inflammatory and skin-specific gene signatures reveal common drivers of discoid lupus erythematosus in canines, humans and mice
- Using Gene Expression Analysis to Understand Complex Autoimmune Skin Disease Patients: A Series of Four Canine Cutaneous Lupus Erythematosus Cases
Morphea (Localized Scleroderma)
- Jak Inhibition Prevents Bleomycin-Induced Fibrosis in Mice and Is Effective in Patients with Morphea
- CXCL9 Links Skin Inflammation and Fibrosis through CXCR3-Dependent Upregulation of Col1a1 in Fibroblasts
Alopecia
Pemphigus
Multiple Sclerosis
Cutaneous T Cell Lymphoma
- Interleukin-16 as a marker of Sézary syndrome onset and stage
- Immunopathogenesis of cutaneous T-cell lymphoma in skin of color patients part 1: Mycosis fungoides
- Immunopathogenesis of cutaneous T-cell lymphoma in skin of color patients part 2: Sézary syndrome
Full list of our publications:
https://www.ncbi.nlm.nih.gov/pubmed/?term=jillian+richmond
Special thanks to the organizations who fund our research:
