Michael Purcaro, MD PhD
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Michael Purcaro, MD PhDInternship: University Of Massachusetts Chan, Internal Medicine
Medical School: University Of Massachusetts Chan Medical School, MD/PhD
Post-Baccalaureate: Harvard Extension School, Diploma in Pre-Medical Studies Graduate School: Worcester Polytechnic Institute, MS, Computer Science Undergraduate College: Yale University, BA, Computer Science
Hometown: Watertown, CT
Clinical Interests: Neuroimaging, research applications of machine learning, bioinformatics
Personal Interests: High-performance computing, 3d printing, electronics, engineering, woodworking, machining, travel
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Publications:The ENCODE Project Consortium, Moore J†, Purcaro M†, Pratt H†, Epstein CB†, Shoresh N†, Adrian J†, Kawli T†, Davis CA†, Dobin A†, Kaul R†, Halow J†, Nostrand EL†, Freese P†, Gorkin DU†, Shen Y†, He Y†, Mackiewicz M†, Pauli-Behn F†, Williams BA, Keller CA, Zhang X, Huey J, Dickel DE, Snetkova V, Wei X, Wang X, Rivera-Mulia JC, Rozowsky J, Zhang J, Chhetri SB, Zhang J, Victorsen A, White KP, Visel A, Yeo GW, Burge CB, Lécuyer E, Gilbert DM, Dekker J, Rinn J, Mendenhall EM, Ecker JR, Kellis M, Klein RJ, Noble WS, Kundaje A, Guigó R, Farnham PJ, Cherry JM*, Myers RM*, Ren B*, Graveley BR*, Gerstein MB*, Pennacchio LA*, Snyder MP*, Bernstein BE*, Wold B*, Hardison RC*, Gingeras TR*, Stamatoyannopoulos JA*, Weng Z*. (2020) Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature. PMID: 32728249. (†Authors contributed equally, *Co-corresponding) Moore J, Pratt H, Purcaro M, Weng Z. (2020) A curated benchmark of enhancer-gene interactions for evaluating enhancer-target gene prediction methods. Genome Biology. PMCID: PMC6977301 Fu S, Wang Q, Moore J, Purcaro M, Pratt H, Fan K, Gu C, Jiang C, Zhu R, Kundaje A, Lu A, Weng Z. (2018) Differential Analysis of Chromatin Accessibility and Histone Modifications for Predicting Mouse Developmental Enhancers. Nucleic Acids Research 46(21): 11184-11201. PMCID: PMC6265487 Borrman T, Cimons J, Cosiano M, Purcaro M, Pierce B, Baker B, Weng Z. (2017) ATLAS: a database linking binding affinities with structures for wild-type and mutant TCR-pMHC complexes. Proteins 85(5): 908-916. PMCID: PMC5860664 Akbarian, S., et al. (2015). The PsychENCODE project. Nature Neuroscience.18(12): 1707-1712. PMCID: PMC4675669 Kim JS, Greene MJ, Zlateski A, Lee K, Richardson M, Turaga SC, Purcaro M, Balkam M, Robinson A, Behabadi BF, Campos M, Denk W, Seung HS & the EyeWirers. (2014) Space–time wiring specificity supports direction selectivity in the retina. Nature, 509(7500), 331-336. PMCID: PMC4074887 Mishra A, Ellens D, Schridde U, Motelow J, Purcaro M, DeSalvo M, Enev M, Sanganahalli B, Hyder F, Blumenfeld H (2011) Where fMRI and electrophysiology agree to disagree: corticothalamic and striatal activity patterns in the WAG/Rij rat. Journal of Neuroscience. 31(42), 15053-15064. PMCID: PMC3432284 Englot DJ, Yang L, Hamid H, Danielson N, Bai X, Marfeo A, Yu L, Gordon A, Purcaro M, Motelow JE, Agarwal R, Ellens DJ, Golomb JD, Shamy MCF, Vives K, Spencer DD, Spencer SS, Schevon C, Zaveri HP, Blumenfeld H. (2010) Impaired consciousness in temporal lobe seizures: role of cortical slow activity. Brain, 133(12), 3764-3777. PMCID: PMC2995886 Berman R, Negishi M, Vestal M, Spann M, Chung M, Bai X, Purcaro M, Motelow JE, Danielson N, Dix-Cooper L, Enev M, Novotny EJ, Constable RT, Blumenfeld H. (2010). Simultaneous EEG, fMRI, and behavior in typical childhood absence seizures. Epilepsia, 51(10), 2011-2022. PMCID: PMC2953613 Yang L, Morland T, Schmits K, Rawson E, Narasimhan P, Motelow J, Purcaro M, Peng K; Raouf R, DeSalvo M, Oh T, Wilkerson J, Bod J, Srinivasan J, Kurashvili P, Anaya J, ManzaP, Danielson N, Ransom C, Huh L, Elrich S, Padin-Rosado J, Naidu Y, Detyniecki K, Hamid H, Fattahi P, Astur R, Xiao B, Duckrow R, Blumenfeld H.; (2010) A Prospective Study of Loss of Consciousness in Epilepsy Using Virtual Reality Driving Simulation and Other Video Games. Epilepsy Behav, 18(3), 238-246. PMCID: PMC2914099 Varghese G, Purcaro M, Motelow J, Enev M, McNally K, Levin A, Hirsch L, Tikofsky R, Paige A, Zubal I, Spencer S, Blumenfeld H. (2009). Clinical use of ictal SPECT in secondarily generalized tonic-clonic seizures. Brain, 132(Pt 8), 2102-2113. PMCID: PMC2714057 DeSalvo M, Schridde U, Mishra A, Motelow J, Purcaro M, Danielson N , Hyder F, Blumenfeld H., (2010) Focal BOLD fMRI changes in bicuculline-induced tonic-clonic seizures in the rat. NeuroImage 50(3), 902-909. PMCID: PMC2830359 Purcaro M, Blumenfeld H (2008) SPECT in epilepsy research. In: Philip A. Schwartzkroin, editors Encyclopedia of Basic Epilepsy Research, Vol 2. Oxford: Academic Press; 2009. p. 558-564. Chahboune H, Mishra AM, Desalvo MN, Staib LH, Purcaro M, Scheinost D, Papademetris X, Fyson SJ, Lorincz ML, Crunelli V, Hyder F, Blumenfeld H. (2009). DTI abnormalities in anterior corpus callosum of rats with spike-wave epilepsy. Neuroimage. 47(2), 459-466. PMCID: PMC2712639 Blumenfeld H, Varghese G, Purcaro M, Motelow J, Enev M, McNally K, Levin A, Hirsch L, Tikofsky R, Zubal I, Paige A, Spencer S. (2009). Cortical and subcortical networks in human secondarily generalized tonic-clonic seizures. Brain, 132(Pt 4), 999-1012. PMCID: PMC2724910 Awards:
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