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Selected Publications (out of 37 total)

  1. SY Tse-Kang, KA Wani, ND Peterson, AL Page, F Humphries, R Pukkila-Worley. Intestinal immunity in C. elegans is activated by pathogen effector-triggered aggregation of the guard protein TIR-1 on lysosome-related organelles. Immunity 2024;57:1-16.

  2. SY SY Tse-Kang and R Pukkila-Worley. Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity. Cell Reports 2024;43:114674.

  3. MA Nasrallah, ND Peterson, ES Szumel, P Liu, AL Page, SY Tse, KA Wani, CE Tocheny, R Pukkila-Worley. Transcriptional suppression of sphingolipid catabolism controls pathogen resistance in C. elegans. PLOS Pathogens 2023;19:e1011730.

  4. SY Tse and R Pukkila-Worley. Protocol to assess receptor-ligand binding in C. elegans using adapted thermal shift assays. STAR Protocols 2023;4:102477.

  5. ND Peterson, SY Tse, QJ Huang, KA Wani, CA Schiffer, R Pukkila-Worley. Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans. Immunity 2023;56:1-15.

  6. ND Peterson, JD Isco, JE Salisbury, T Rodriguez, PR Thompson, R Pukkila-Worley. Pathogen infeciton and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition. eLife 2022;11e74206. Cover.

  7. SM Anderson and Pukkila-Worley R. Immunometabolism in Caenorhabditis elegans. PLOS Pathogens 2020 16:e1008897

  8. KJ Foster, HK Cheesman, P Liu, ND Peterson, R Pukkila-Worley. Innate immunity in the C. elegans intestine is programmed by a neuronal regulator of AWC olfactory neuron development. Cell Reports 2020;31:1007478

  9. J Nhan, CD Turner, SM Anderson, CA Yen, HM Dalton, HK Cheesman, DL Reuter, N Uma Naresh, CM Haynes, AA Soukas, R Pukkila-Worley,* SP Curran.* Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection. Proceedings of the National Academy of Sciences U.S.A. 2019;116:22322-22330. *co-corresponding authors

  10. SM Anderson, ND Peterson, HK Cheesman, JE Salisbury, AA Soukas, R Pukkila-Worley. The monounsaturated fatty acid oleate is required for innate immune activation in C. elegans. PLOS Pathogens 2019;15:e1007893.

  11. ND Peterson,HK Cheesman, P Liu, SM Anderson, KJ Foster,R Chhaya, P Perrat, J Thekkiniath, Q Yang, CM Haynes, R Pukkila-Worley. The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans. PLOS Genetics 2019;15:e1007935.

  12. P Deng, N Uma Naresh, Y Du, R Pukkila-Worley and CM Haynes. Pseudomonas aeruginosa virulence impairs the UPRmt by engaging a host negative feedback loop. Proceedings of the National Academy of Sciences U.S.A. 2019;116:22322-22330.

  13. ND Peterson and R Pukkila-Worley. Caenorhabditis elegans in high-throughput screens for anti-infective compounds. Current Opinion in Immunology 2018;54:59-65.

  14. HK Cheesman, RL Feinbaum, J Thekkiniath, RH Dowen, AL Conery, R Pukkila-Worley. Aberrant activation of p38 MAP kinase-dependent innate immune responses is toxic to C. elegans. G3: Genes, Genomes, Genetics 2016;6:541-549.

  15. R Pukkila-Worley. Surveillance immunity: An emerging paradigm of Innate Defense Activation in Caenorhabditis elegans. PLOS Pathogens 2016;12:e1005795.

  16. R Pukkila-Worley,* RL Feinbaum, DL McEwan, AL Conery, FM Ausubel. The evolutionarily conserved mediator subunit MDT-15/MED15 links protective innate immune responses and xenobiotic detoxification. PLOS Pathogens 2014; 10:e1004143.*corresponding author

  17. R Pukkila-Worley, N Valentina and JA Branda. Case records of the Massachusetts General Hospital. Case-28-2014: A 39-year-old man with a rash, headache, fever, nausea and photophobia. New England Journal of Medicine 2014;371:1051-1060.

  18. R Pukkila-Worley, R Feinbaum, NV Kirienko, J Larkins-Ford, AL Conery, FM Ausubel. Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection. PLOS Genetics 2012;8:e1002733.

  19. R Pukkila-Worley and FM Ausubel. Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium. Current Opinion in Immunology 2012;1:3-9.

  20. R Pukkila-Worley, FM Ausubel and E Mylonakis. Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses. PLOS Pathogens 2011;7:e1002074. 

  21. R Pukkila-Worley, AY Peleg, E Tampakakis and E Mylonakis. Candida albicans hyphal formation and virulence assessed using a Caenorhabditis elegans infection model. Eukaryotic Cell 2009;8:1750. Cover.