Interactions with the Immune Response

We investigate how the microbiome affects innate and adaptive immunity. We combine metagenomic sequencing, transcriptomics, immune phenotyping, and metabolomics to determine bacterial species and functions that are responsible for inducing immune signatures that are relevant to several inflammatory and infectious conditions. Two main areas of research relate to the tuft-cells → IL25 → intestinal barrier axis and the other to the PgP → XXX → YYYYY. Additionally, we leverage multimodal translational medicine data from collaborations with both academic and industry partners around the country to determine associations between microbiome dynamics and peripheral inflammatory responses in humans.

Top Publications:

• Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia
• Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells

• Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis

• Computer-guided design of optimal microbial consortia for immune system modulation