Our Research Focus:

• Virus-Host Interactions
• Antiviral Immunity and Inflammation at Barrier Surfaces
• 3D Skin Organoids

Representative Publications

• Parameswaran P., Payne L., Powers J. Rashighi M., Orzalli M.H. (2024) A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 inflammasome. J Exp Med, 221(8):e20231518.
  
  
• Orzalli M.H., Prochera A., Payne L., Smith A., Garlick J.A., Kagan J.C. (2021) Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin E-dependent pyroptosis in barrier epithelial cells. Immunity, S1074-7613(21)00174-6. 
  
  
• Orzalli M.H., Smith A.V., Jurado K.A., Iwasaki A., Garlick J.A., and Kagan J.C. (2018) An antiviral branch of the IL-1 signaling pathway restricts immune-evasive virus replication. Molecular Cell, 71(5):825-840.e6.
  
  

More Publications

Join our Lab

The Orzalli Lab is currently recruiting a post-doctoral fellow. If you are interested in our joining our team, please send a cover letter, CV, and contact information for three references to Dr. Megan Orzalli.