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The study aimed to understand the link between viral infections such as HCMV and neurodegenerative diseases such as Alzheimer’s.

Top story: UMass Chan leaders and invited dignitaries cut the ribbon on the new education and research building, as WHO Director-General Tedros Adhanom Ghebreyesus, PhD, received an honorary degree and delivered the keynote address. 

Among the newly endowed chairs, five are new UMass Memorial Health chairs, made possible through the long-standing partnership with UMass Chan.

A $5 million philanthropic gift from UMass Memorial Health and $2.5 million in matching funds from the University of Massachusetts Foundation will allow UMass Chan to establish five new ‘UMass Memorial Health’ endowed chairs. Furthermore, seven additional new endowed chairs are being established, meeting the institutional goal of 75 endowed chairs by 2025.  

Four faculty members were honored with chancellor’s medals, and seven others were invested as named professors at the annual Convocation and Investiture celebration.

Festivities kick off on Friday, Sept. 6, with the T.H. Chan School of Medicine White Coat Ceremony, welcoming the new class of medical students into the medical community.

A family whose child has a rare neurological disease, SPG4, visited UMass Chan Medical School’s scientists to learn about development of a gene therapy for the disease. The family is raising funds to support the research in the Translational Institute for Molecular Therapeutics. 

Stroke survivors often experience spatial neglect, an underdiagnosed condition impairing their ability to navigate their surroundings. In a new article for The Conversation, A.M. Barrett, MD, chair and professor of neurology, and Kevin Houston, OD, MSc, associate professor of neurology, highlight prism adaptation therapy as a promising treatment. This simple, effective therapy significantly improves patients' spatial awareness and independence.

UMass Chan Medical School has received $2.2 million from a nonprofit patient-advocacy organization to contract with Andelyn Biosciences to manufacture clinical grade AAV9-CSA vector to treat Cockayne syndrome.  

UMass Chan leaders and invited dignitaries cut the ribbon on the new education and research building, as WHO Director-General Tedros Adhanom Ghebreyesus, PhD, received an honorary degree and delivered the keynote address.  

The 12-month program is the longest-running professional development program at UMass Chan Medical School and has nearly 300 graduates.

A tightly choreographed process to move faculty, staff and equipment into the new education and research building on the Worcester campus has begun. The building opening will be celebrated with a ribbon-cutting ceremony on June 7.  

As they make their way 26.2 miles from Hopkinton to Copley Square on April 15, the UMass ALS Cellucci Fund Boston Marathon Team will be the largest group of runners in the team’s 13-year history of raising funds to support ALS research.

Natick resident and Stanford Online High School student Rebecca Ahn outperformed other local high school students in the final round of the competition on March 16.

Students will be competing for the Andrew Sheridan Young Neuroscientist Award and an all-expense paid trip to participate in the 2024 USA National Bee at the University of Central Florida in April. 

Construction equipment and office trailers used in the construction of the new education and research building at UMass Chan will soon be removed as construction enters the final phase before completion of the building in early June.

The scientists will use a human cerebral organoid platform to evaluate the role of COVID in neurodegenerative diseases, such as Alzheimer’s, Parkinson’s and dementia.  

MD/PhD student Abigail Hiller has received an award from the National Institute of Neurological Disorders and Stroke to study the role genes linked to Alzheimer’s disease play in ALS.

A multisite Veterans Affairs study led by A.M. Barrett, MD, and Kevin Houston, OD, aims to define and validate brain imaging biomarkers that predict response to prism adaptation therapy in patients with spatial neglect following right-brain stroke.

New study led by Nils Henninger, MD, PhD'18, suggests interplay between genetic factors and traumatic brain injury in behavioral and neurological deficits related to ALS and FTD in mice.

Military veterans face a higher risk of ALS than the civilian population, according to years of studies. UMass Chan researchers are pursuing therapies to address the biological basis for this fatal neurodegenerative disease and work with clinical partners to provide expert rehabilitation for veterans.

The Angel Fund for ALS Research has announced a $711,000 donation to support the research of Robert H. Brown Jr., DPhil, MD, at UMass Chan Medical School.

Sisters Ashley Craig and Lacey Foley joined the UMass ALS Cellucci Fund Boston Marathon team in memory of their grandmother. Brothers Dean and Zack Kennedy, PhD’19, are running on the Jake Kennedy ALS Fund team, in honor of their father.

In a piece written for The Conversation, Fen-Biao Gao, PhD, talks about how frontotemporal dementia changes the brain and the research that is untangling its genetic causes.

Researchers working with UMass Chan Medical School’s Translational Institute for Molecular Therapeutics announced progress in developing a vector to deliver gene replacement therapy in mice models with Cockayne syndrome, a rare and fatal neurodegenerative disease that largely affects children and young adults.

Top story: An international team of investigators has discovered that an inorganic polyphosphate released by nerve cells known as astrocytes in people with ALS and frontotemporal dementia contributes to the motor neuron death that is the signature of these diseases.

Top story: The Translational Institute for Molecular Therapeutics leverages UMass Chan Medical School’s extensive experience in researching and developing gene therapies for early-stage clinical trials. Miguel Sena-Esteves, PhD, is director of the new institute.

U.S. Sen. Edward Markey toured the Veterans Affairs community-based outpatient clinic on the campus of UMass Chan Medical School in Worcester on Tuesday.

A pilot clinical trial led by UMass Chan Medical School and Yale School of Medicine may have unlocked an important tool for families to review all treatment options for patients in the neuroscience intensive care unit incapable of making their own decisions.

In his annual Convocation address to the UMass Chan Medical School community on Thursday, Sept. 16, Chancellor Michael F. Collins expressed optimism for the Medical School’s ambitious future and touted the enormous momentum moving the school forward.

The Morningside Graduate School of Biomedical Sciences honored the new doctoral candidates during its annual Qualifying Exam Recognition Ceremony on Wednesday, Sept. 14, at which Dean Mary Ellen Lane encouraged the honorees to continue “growing, learning and stretching out of your comfort zone.”

The 2022 Dan and Diane Riccio Fund for Neuroscience seed grants will support four teams of researchers collaborating on multidisciplinary projects.

Physician-scientist A.M. Barrett, MD, is joining UMass Chan Medical School as chair and professor of neurology. Additionally, Dr. Barrett has been named chief of the Neurology Service at the VA Central Western Massachusetts Healthcare System.

UMass Chan Medical School celebrated in a special investiture ceremony on June 22 the $5 million gift of UMass Lowell alumni Donna and Robert Manning, which established Donna M. and Robert J. Manning Chairs in neurosciences, orthopedics, obstetrics and gynecology, nursing, and biomedical sciences.

Chancellor Michael F. Collins announced that the University’s Board of Trustees has approved the appointment of three of faculty members to endowed chairs. They join more than 60 named chairs at UMass Chan.

Five new endowed chairs have been established at UMass Chan Medical School, thanks to the generosity of Donna and Robert Manning, proud alumni and preeminent pillars of the University of Massachusetts.

ALS research at UMass Chan Medical School is the big beneficiary as select Boston Marathon runners raise tens of thousands of dollars each year. This year, five competitors in the April 18 event are running as part of the UMass Chan ALS Cellucci Fund Boston Marathon team and two sons of the late Jake Kennedy will run in support of the Jake Kennedy ALS Fund.

Charles P Emerson Jr., PhD, and colleagues at UMass Chan Medical School have developed a technology to isolate human skeletal muscle stem cells, or progenitor cells, from induced pluripotent stem cells.

An international team of investigators has discovered that an inorganic polyphosphate released by nerve cells known as astrocytes in people with ALS and frontotemporal dementia contributes to the motor neuron death that is the signature of these diseases.

Hosted by the Departments of Neurobiology and Psychiatry and the NeuroNexus Institute at UMass Chan Medical School on Saturday, Feb. 5, the annual Brain Bee competition was created to encourage high school students to learn more about the neurosciences.

Robert H. Brown Jr., DPhil, MD, Jonathan Watts, PhD, and colleagues showed the ability to suppress mutant forms of the ALS gene known as C9ORF72 in a single-patient pilot study. The paper reporting the results is part of the 2022 STAT News STAT Madness competition.

In a piece written for The Conversation, Miguel Sena-Esteves, PhD, talks about research leading to the first ever gene therapy for Tay-Sachs disease and the launch of the Translational Institute for Molecular Therapeutics at UMass Chan.

An Oregon couple whose baby was diagnosed with an ultra-rare genetic disorder has launched a foundation to raise money to accelerate development of therapies for the condition and recently signed a gift agreement with UMass Chan Medical School to jump start the research.

The Translational Institute for Molecular Therapeutics leverages UMass Chan Medical School’s extensive experience in researching and developing gene therapies for early-stage clinical trials. Miguel Sena-Esteves, PhD, is director of the new institute.

Robert H. Brown Jr., DPhil, MD, Jonathan Watts, PhD, and colleagues have shown the ability to suppress mutant forms of an ALS gene in a single-patient pilot study.

Sio Gene Therapies, a clinical-stage company focused on developing gene therapies for neurodegenerative diseases, presented positive interim data from its Phase I/II study of AXO-AAV-GM1, an adeno-associated viral vector-based gene therapy candidate for GM1 gangliosidosis that was licensed from UMass Chan.

Riaan Research Initiative, a non-profit organization, and UMass Chan Medical School are entering into an agreement to fund, research and develop a gene replacement therapy to combat Cockayne syndrome, a fatal autosomal recessive disorder.

Two studies from the lab of Daryl Bosco, PhD, offer new insights into the biochemical and molecular mechanisms that cause amyotrophic lateral sclerosis.

Five runners are participating in the 125th running of the Boston Marathon on Oct. 11 to raise money for UMass Medical School’s ALS Cellucci Fund.

The Dan and Diane Riccio Fund for Neuroscience has awarded four teams of UMass Medical School researchers $50,000 seed grants for interdisciplinary collaborations leading to innovative discoveries that deepen understanding of normal brain function and what goes awry in neurological diseases.

Heather Gray-Edwards, PhD, DVM; Miguel Sena-Esteves, PhD; and Raymond Dunn, MD, are the recipients of the Office of Business Development & Innovation 2021 BRIDGE Fund grants.

Thomas Feldborg and Daria Rokina, of Denmark, chose to enroll their baby daughter, Alissa, in an investigational gene therapy for the treatment of GM2 gangliosidosis, which causes Tay-Sachs and Sandhoff diseases, to “let hope conquer the fears,” according to a report in USA Today chronicling their journey.

Apic Bio, a gene therapy company developing treatment options for patients with rare genetic diseases and co-founded by UMass Medical School’s Robert H. Brown Jr., DPhil, MD, announced that the FDA has cleared its investigational new drug application for APB-102, a gene therapy candidate designed to treat a common cause of familial amyotrophic lateral sclerosis.

The annual event, designed to stimulate high school students’ interest in neuroscience, was hosted by the Departments of Psychiatry and Neurology and the NeuroNexus Institute at UMass Medical School via Zoom on Saturday, March 20.

The 15th annual Brain Bee competition for Massachusetts high school students will be hosted by the Departments of Psychiatry and Neurology and the NeuroNexus Institute at UMass Medical School via Zoom.

Oguz Cataltepe, MD, describes the innovative neurosurgical procedure used to treat patients in the new clinical trial for a gene therapy targeting infantile Tay-Sachs and Sandhoff diseases.

Sio Gene Therapies announced that the first patient with infantile Tay-Sachs disease has been dosed in a Phase I/II trial evaluating AXO-AAV-GM2, an investigational gene therapy for the treatment of GM2 gangliosidosis, which causes Tay-Sachs and Sandhoff diseases. Miguel Sena-Esteves, PhD, is a principal scientist of the research program at UMMS.

Axovant Gene Therapies, a clinical-stage company developing innovative gene therapies based on UMass Medical School research discoveries, has announced that the FDA has lifted its clinical hold and cleared Axovant’s Investigational New Drug application to initiate a registrational study of gene therapy to treat patients with Tay-Sachs disease and Sandhoff disease.

On behalf of the UMass Medical School community, we extend our sincere condolences to Jake Kennedy’s family and to all who knew and loved him. Jake Kennedy died Tuesday, Oct. 13, at age 65, in his Salem, N.H., home of amyotrophic lateral sclerosis.

Jonathan Smith, of Worcester; Alyssa Smith, of Woodstock, Vt.; and Jennifer Bolanos, of Wilmington, are running the virtual Boston Marathon to support the UMass ALS Cellucci Fund.

UMass Medical School and Massachusetts General Hospital are the first to safely treat two research participants with a synthetic microRNA, delivered into the spinal fluid, designed to silence a human disease-causing gene. Details of the treatment appear in the New England Journal of Medicine.

Salome Funes, PhD candidate in the Graduate School of Biomedical Sciences, and the Society for the Advancement of Chicanos and Native Americans in Science are reaching out to organizations like Girls Inc. to teach young women about careers in science.

In a new Voices of UMassMed podcast, Kara Smith, MD, talks about early warning signs of Parkinson’s disease and new developments in research.

The Angel Fund for ALS Research donated $1 million last year to support the research of Robert H. Brown Jr., DPhil, MD. The sole mission of the nonprofit organization is to find a treatment and cure for ALS.