Research Focus: Unraveling molecular mechanisms controlling liver fibrosis.​

• Defining pathways that regulate hepatic stellate cell function
• Combining in vivo mouse studies, liver organoid biology, and single-cell analysis of human tissue to understand disease progression and identify points of intervention
• Targeting coding and long noncoding gene products to modulate disease

Representative Publications

• Rahman R., Ahmad I., Sparks R., Ben Saad A., Mullen A.C. (2022). Singletrome: A method to analyze and enhance the transcriptome with long noncoding RNAs for single cell analysis. bioRxiv.
  
  
• Hess A., Gentile S.D., Ben Saad A., Rahman R., Habboub T., and Mullen A.C. (2022) Human liver organoids model progressive inflammatory and fibrotic injury in non-alcoholic fatty liver disease. bioRxiv. 
  
  
• Li W., Chen J.Y., Sun S., Sparks R.P., Pantano L., Rahman R., Moran S.P., Pondick J.V., Kirchner R., Wrobel D., Bieler M., Ho Sui S.J., Doerner J.F., Rippmann J.F., Mullen A.C. (2022). Nanchangmycin regulates FYN, FAK and ERK to control the fibrotic activity of human hepatic stellate cells. eLife. 74513. 
  
  
• Daneshvar K., Ardehali M.B., Klein I.A., Fu-Kai H., Kratkiewicz A.J., Mahpour A., Cancielliere S.O.L., Zhou C., Cook B.M., Li­­ W., Pondick J.V., Gupta S.K., Moran S.P., Young R.A., Kingston R.E., Mullen, A.C. (2020). lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation. Nature Cell Biology. 22, 1211-1222. 

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