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Publications

MassBiologics Staff Publications

2022

  1. Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants. Li Q, Humphries F, Girardin RC, Wallace A, Ejemel M, Amcheslavsky A, McMahon CT, Schiller ZA, Ma Z, Cruz J, Dupuis AP, Payne AF, Maryam A, Yilmaz NK, McDonough KA, Pierce BG, Schiffer CA, Kruse AC, Klempner MS, Cavacini LA, Fitzgerald KA, Wang Y. Front Immunol. 2022 Sep 12; PMID: 36172366 
  2. A cocktail of human monoclonal antibodies broadly neutralizes North American rabies virus variants as a promising candidate for rabies post-exposure prophylaxis. Ejemel M, Smith TG, Greenberg L, Carson WC, Lowe D, Yang Y, Jackson FR, Morgan CN, Martin BE, Kling C, Hutson CL, Gallardo-Romero N, Ellison JA, Moore S, Buzby A, Sullivan-Bolyai J, Klempner M, Wang Y. Sci Rep. 2022 Jun 7;12(1):9403. PMID: 35672343 
  3. Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike. Díaz-Salinas MA, Li Q, Ejemel M, Yurkovetskiy L, Luban J, Shen K, Wang Y, Munro JB. Elife. 2022 Mar 24;11. PMID: 35323111 
  4. Agglutination of Borreliella burgdorferi by Transmission-Blocking OspA Monoclonal Antibodies and Monovalent Fab Fragments. Frye AM, Ejemel M, Cavacini L, Wang Y, Rudolph MJ, Song R, Mantis NJ. Infect Immun. 2022 Sep 15;90 (9) PMID: 36000876
  5. Genetic modifications designed for xenotransplantation attenuate sialoadhesin-dependent binding of human erythrocytes to porcine macrophages. Petitpas K, Habibabady Z, Ritchie V, Connolly MR, Burdorf L, Qin W, Kan Y, Layer JV, Crabtree JN, Youd ME, Westlin WF, Magnani DM, Pierson RN 3rd, Azimzadeh AM. Xenotransplantation. 2022 Sep 20 PMID: 36125388

2021

  1. Blocking Borrelia burgdorferi transmission from infected ticks to non-human primates with a human monoclonal antibody. Schiller ZA, Rudolph MJ, Toomey JR, Ejemel M, LaRochelle A, Davis SA, Lambert HS, Kern A, Tardo AC, Souders CA, Peterson E, Cannon RD, Ganesa C, Fazio F, Mantis NJ, Cavacini LA, Sullivan-Bolyai J, Hu LT, Embers ME, Klempner MS, Wang Y. J Clin Invest. 2021 Apr 29. PMID:33914704
  2. Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design. Amcheslavsky A, Wallace AL, Ejemel M, Li Q, McMahon CT, Stoppato M, Giuntini S, Schiller ZA, Pondish JR, Toomey JR, Schneider RM, Meisinger J, Heukers R, Kruse AC, Barry EM, Pierce BG, Klempner MS, Cavacini LA, Wang Y. Sci Rep. 2021 Feb 02; 11(1):2751. PMID: 33531570.
  3. Investigation of a monoclonal antibody against enterotoxigenic Escherichia coli, expressed as secretory IgA1 and IgA2 in plants.Teh AY, Cavacini L, Hu Y, Kumru OS, Xiong J, Bolick DT, Joshi SB, Grünwald-Gruber C, Altmann F, Klempner M, Guerrant RL, Volkin DB, Wang Y, Ma JK. Gut Microbes. 2021 Jan-Dec; 13(1):1-14. PMID: 33439092.
  4. Serological analysis reveals an imbalanced IgG subclass composition associated with COVID-19 disease severity. Yates JL, Ehrbar DJ, Hunt DT, Girardin RC, Dupuis AP 2nd, Payne AF, Sowizral M, Varney S, Kulas KE, Demarest VL, Howard KM, Carson K, Hales M, Ejemel M, Li Q, Wang Y, Peredo-Wende R, Ramani A, Singh G, Strle K, Mantis NJ, McDonough KA, Lee WT .Cell Rep Med. 2021 Jul 20;2(7). PMID: 34151306
  5. Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model.  Manook M, Flores WJ, Schmitz R, Fitch Z, Yoon J, Bae Y, Shaw B, Kirk A, Harnois M, Permar S, Farris AB, Magnani DM, Kwun J, Knechtle S. Front Immunol. 2021 Jun 2.PMID: 34149698 
  6. A comparative study of human-and rhesus-specific antithymocyte globulins in Rhesus macaques. Shaw BI, Schmitz R, Flores WJ, Magnani DM, Li J, Song M, Kirk AD. Clin Transplant. 2021 Aug;35(8) PMID: 34021521
  7. Non-neutralizing Antibodies May Contribute to Suppression of SIVmac239 Viremia in Indian Rhesus Macaques. Pedreño-Lopez N, Rosen BC, Flores WJ, Gorman MJ, Voigt TB, Ricciardi MJ, Crosno K, Weisgrau KL, Parks CL, Lifson JD, Alter G, Rakasz EG, Magnani DM, Martins MA, Watkins DI. Front Immunol. 2021 Mar 16. PMID: 33796119
  8. Biophysical Evaluation of Rhesus Macaque Fc Gamma Receptors Reveals Similar IgG Fc Glycoform Preferences to Human Receptors. Crowley AR, Osei-Owusu NY, Dekkers G, Gao W, Wuhrer M, Magnani DM, Reimann KA, Pincus SH, Vidarsson G, Ackerman ME. Front Immunol. 2021 Oct 12; PMID: 34712242

2020

  1. IgA as a potential candidate for enteric monoclonal antibody therapeutics with improved gastrointestinal stability. Wallace AL, Schneider MI, Toomey JR, Schneider RM, Klempner MS, Wang Y, Cavacini LA. Vaccine. 2020 Nov 3;38 (47):7490-7497. doi: 10.1016/j.vaccine.2020.09.070. PMID: 33041102
  2. Highly Specific Mouse Anti-Joining Chain of Human Immunoglobulin A. Ejemel M, Gawron MA, Schneider MI, Wallace A, Schiller ZA, Schneider R, Martin JC, Klempner MS, Wang Y, Cavacini LA. Monoclon Antib Immunodiagn Immunother. 2020 Oct 29. doi: 10.1089/mab.2020.0031. PMID: 33121367
  3. A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction. Ejemel M, Li Q, Hou S, Schiller ZA, Tree JA, Wallace A, Amcheslavsky A, Kurt Yilmaz N, Buttigieg KR, Elmore MJ, Godwin K, Coombes N, Toomey JR, Schneider R, Ramchetty AS, Close BJ, Chen DY, Conway HL, Saeed M, Ganesa C, Carroll MW, Cavacini LA, Klempner MS, Schiffer CA, Wang Y. Nat Commun. 2020 Aug 21;11 (1):4198. doi: 10.1038/s41467-020-18058-8. PMID: 32826914
  4. Oral administration of an anti-CfaE secretory IgA antibody protects against Enterotoxigenic Escherichia coli diarrheal disease in a nonhuman primate model. Stoppato M, Gaspar C, Regeimbal J, Nunez RG, Giuntini S, Schiller ZA, Gawron MA, Pondish JR, Martin JC 3rd, Schneider MI, Klempner MS, Cavacini LA, Wang Y. Vaccine. 2020 Feb 28;38 (10):2333-2339. doi:10.1016/j.vaccine.2020.01.064. PMID: 32008877
  5. IL-10 impairs local immune response in lung granulomas and lymph nodes during early mycobacterium tuberculosis infection. Wong EA, Evans S, Kraus CR, Engelman KD, Maiello P, Flores WJ, Cadena AM, Klein E, Thomas K, White AG, Causgrove C, Stein B, Tomko J, Mattila JT, Gideon H, Lin PL, Reimann KA, Kirschner DE, Flynn JL. J Immunol. 2020 Feb 1;204 (3):644-659. doi:10.4049/jimmunol.1901211. PMID: 31862711
  6. Anti-CD40 antibody 2C10 binds to a conformational epitope at the CD40-CD154 interface that is conserved among primate species. Michaels AJ, Stoppato M, Flores WJ, Reimann KA, Engelman KD. Am J Transplant. 2020 Jan; 20(1):298-305. doi: 10.1111/ajt.15574. PMID: 31430418;
  7. Preformulation Characterization and Stability Assessments of Secretory IgA Monoclonal Antibodies as Potential Candidates for Passive Immunization by Oral Administration. Hu Y, Kumru OS, Xiong J, Antunez LR, Hickey J, Wang Y, Cavacini L, Klempner M, Joshi SB, Volkin DB. J Pharm Sci. 2020 Jan; 109(1):407-421. PMID: 31369743

  2019

  1. Inhibition of Allergic Reactivity through Targeting FcεRI-Bound IgE with Humanized Low-Affinity Antibodies. Zhang K, Elias M, Zhang H, Liu J, Kepley C, Bai Y, Metcalfe DD, Schiller Z, Wang Y, Saxon A.  J Immunol. 2019 Dec 1;203 (11):2777-2790. doi: 10.4049/jimmunol.1900112. PMID: 31636239. 
  2. Evaluation of an antibody to a4b7 in the control of SIVmac239-nef-stop infection. Di Mascio M, Lifson JD, Srinivasula S, Kim I, DeGrange P, Keele BF, Belli AJ, Reimann KA, Wang Y, Proschan M, Lane HC, Fauci AS. Science. 2019 Sep 6;365 (6457):1025-1029. doi:10.1126/science.aav6695. PMID: 31488688.
  3. Lack of therapeutic efficacy of an antibody to a4b7 in SIVmac251-infected rhesus macaques. Abbink P, Mercado NB, Nkolola JP, Peterson RL, Tuyishime H, McMahan K, Moseley ET, Borducchi EN, Chandrashekar A, Bondzie EA, Agarwal A, Belli AJ, Reimann KA, Keele BF, Geleziunas R, Lewis MG, Barouch DH. Science. 2019 Sep 6; 365(6457):1029-1033. doi:10.1126/science.aaw8562. PMID: 31488689;
  4. Blocking a4b7 integrin binding to SIV does not improve virologic control. Iwamoto N, Mason RD, Song K, Gorman J, Welles HC, Arthos J, Cicala C, Min S, King HAD, Belli AJ, Reimann KA, Foulds KE, Kwong PD, Lifson JD, Keele BF, Roederer M. Science. 2019 Sep 6; 365(6457):1033-1036. doi:10.1126/science.aaw7765. PMID: 31488690.
  5. Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition. Haraszti RA, Miller R, Dubuke ML, Rockwell HE, Coles AH, Sapp E, Didiot MC, Echeverria D, Stoppato M, Sere YY, Leszyk J, Alterman JF, Godinho BMDC, Hassler MR, McDaniel J, Narain NR, Wollacott R, Wang Y, Shaffer SA, Kiebish MA, DiFiglia M, Aronin N, Khvorova A.  iScience. 2019 Jun 28;16:230-241. doi: 10.1016/j.isci.2019.05.029. PMID: 31195240;
  6. Anti-OspA DNA-Encoded Monoclonal Antibody Prevents Transmission of Spirochetes in Tick Challenge Providing Sterilizing Immunity in Mice. Wang Y, Esquivel R, Flingai S, Schiller ZA, Kern A, Agarwal S, Chu J, Patel A, Sullivan K, Wise MC, Broderick KE, Hu L, Weiner DB, Klempner MS.  J Infect Dis. 2019 Mar 15;219 (7):1146-1150. doi: 10.1093/infdis/jiy627.  PMID: 30476132;
  7. Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1. Gawron MA, Duval M, Carbone C, Jaiswal S, Wallace A, Martin JC 3rd, Dauphin A, Brehm MA, Greiner DL, Shultz LD, Luban J, Cavacini LA. J Immunol. 2019 Feb 1;202(3):799-804. doi: 10.4049/jimmunol.1801085. PMID: 30593536

2018
  1. Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity. Haraszti RA, Miller R, Stoppato M, Sere YY, Coles A, Didiot MC, Wollacott R, Sapp E, Dubuke ML, Li X, Shaffer SA, DiFiglia M, Wang Y, Aronin N, Khvorova A.  Mol Ther. 2018 Dec 5;26(12):2838-2847. doi: 10.1016/j.ymthe.2018.09.015. PMID: 30341012;
  2. Immunoglobulin Function. Greenspan NS and Cavacini LA.  In: RR Rich, ed. Clinical Immunology.  Principles and Practice, 5th Edition.  Elsevier. 2018:223-234.
  3. Identification and Characterization of Human Monoclonal Antibodies for Immunoprophylaxis against Enterotoxigenic Escherichia coli Infection Giuntini S, Stoppato M, Sedic M, Ejemel M, Pondish JR, Wisheart D, Schiller ZA, Thomas WD Jr, Barry EM, Cavacini LA, Klempner MS, Wang Y. Infect Immun. 2018 Jul 23; 86(8):e00355-18. doi: 10.1128/IAI.00355-18. PMID: 29866909 
  4. Comparison of a Novel Human Rabies Monoclonal Antibody to Human Rabies Immunoglobulin for Postexposure Prophylaxis: A Phase 2/3, Randomized, Single-Blind, Noninferiority, Controlled Study. Gogtay NJ, Munshi R, Ashwath Narayana DH, Mahendra BJ, Kshirsagar V, Gunale B, Moore S, Cheslock P, Thaker S, Deshpande S, Karande S, Kumbhar D, Ravish HS, Harish BR, Pisal SS, Dhere R, Parulekar V, Blackwelder WC, Molrine DC, Kulkarni PS.Clin Infect Dis. 2018 Jan 18;66(3):387-395. doi: 10.1093/cid/cix791.PMID: 29020321  

2017
  1. Characterization of serum anti-diphtheria antibody activity following administration of equine anti-toxin for suspected diphtheria. Smith HL, Saia G, Lobikin M, Tiwari T, Cheng SC, Molrine DC.Hum Vaccin Immunother. 2017 Nov 2; 13(11):2738-2741. doi: 10.1080/21645515.2017.1362516. PMID: 28933665 
  2. Structure-Based Design of Hepatitis C Virus Vaccines That Elicit Neutralizing Antibody Responses to a Conserved Epitope. Pierce BG, Boucher EN, Piepenbrink KH, Ejemel M, Rapp CA, Thomas WD Jr, Sundberg EJ, Weng Z, Wang Y.  J Virol. 2017 Oct 15; 91(20). doi: 10.1128/JVI.01032-17. PMID: 28794021; 
  3. Structural and molecular analysis of a protective epitope of Lyme disease antigen OspA and antibody interactions. Shandilya S, Kurt Yilmaz N, Sadowski A, Monir E, Schiller ZA, Thomas WD Jr, Klempner MS, Schiffer CA, Wang Y.  J Mol Recognit. 2017 May; 30(5). doi: 10.1002/jmr.2595. PMID: 27859766; 
  4. Prevention of allograft HCV recurrence with peri-transplant human monoclonal antibody MBL-HCV1 combined with a single oral direct-acting antiviral: A proof-of-concept study. Smith HL, Chung RT, Mantry P, Chapman W, Curry MP, Schiano TD, Boucher E, Cheslock P, Wang Y, Molrine DC.  J Viral Hepat. 2017 Mar; 24(3):197-206. doi: 10.1111/jvh.12632. PMID: 28127942. 
  5. Prevention of allograft HCV recurrence with peri-transplant human monoclonal antibody MBL-HCV1 combined with a single oral direct-acting antiviral: A proof-of-concept study. Smith HL, Chung RT, Mantry P, Chapman W, Curry MP, Schiano TD, Boucher E, Cheslock P, Wang Y, Molrine DC.J Viral Hepat. 2017 Mar; 24(3):197-206. doi: 10.1111/jvh.12632. PMID: 28127942 

2016
  1. Potency of a human monoclonal antibody to diphtheria toxin relative to equine diphtheria anti-toxin in a guinea pig intoxication model. Smith HL, Cheslock P, Leney M, Barton B, Molrine DC.Virulence. 2016 Aug 17;7(6):660-8. doi: 10.1080/21505594.2016.1171436. PMID: 27070129
  2. Pre-exposure Prophylaxis With OspA-Specific Human Monoclonal Antibodies Protects Mice Against Tick Transmission of Lyme Disease Spirochetes. Wang Y, Kern A, Boatright NK, Schiller ZA, Sadowski A, Ejemel M, Souders CA, Reimann KA, Hu L, Thomas WD Jr, Klempner MS.  J Infect Dis. 2016 Jul 15;214 (2):205-11. doi: 10.1093/infdis/jiw151. PMID: 27338767 
  3. Overcoming the Constraints of Anti-HIV/CD89 Bispecific Antibodies That Limit Viral Inhibition. Yu X, Duval M, Gawron M, Posner MR, Cavacini LA. J Immunol Res. 2016 Jun 22 2016:9425172. doi: 10.1155/2016/9425172. PMID: 27419146 
  4. Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak. Bornholdt ZA, Turner HL, Murin CD, Li W, Sok D, Souders CA, Piper AE, Goff A, Shamblin JD, Wollen SE, Sprague TR, Fusco ML, Pommert KB, Cavacini LA, Smith HL, Klempner M, Reimann KA, Krauland E, Gerngross TU, Wittrup KD, Saphire EO, Burton DR, Glass PJ, Ward AB, Walker LM.Science. 2016 Mar 4;351(6277):1078-83. doi: 10.1126/science.aad5788. PMID: 26912366
  5. Pathogenicity and Epitope Characteristics Do Not Differ in IgG Subclass-Switched Anti-Desmoglein 3 IgG1 and IgG4 Autoantibodies in Pemphigus Vulgaris. Lo AS, Mao X, Mukherjee EM, Ellebrecht CT, Yu X, Posner MR, Payne AS, Cavacini LA. PLoS One. 2016 Jun 15;11(6):e0156800. doi: 10.1371/journal.pone.0156800. PMID: 27304671 

2015 and earlier
  1. Circulating Levels of sFlt1 Splice Variants as Predictive Markers for the Development of Preeclampsia. Souders CA, Maynard SE, Yan J, Wang Y, Boatright NK, Sedan J, Balyozian D, Cheslock PS, Molrine DC, Simas TA. Int J Mol Sci. 2015 Jun 2;16(6):12436-53. doi: 10.3390/ijms160612436.  PMID: 26042465 
  2. A novel in vitro assay to predict neonatal Fc receptor-mediated human IgG half-life. Souders CA, Nelson SC, Wang Y, Crowley AR, Klempner MS, Thomas W Jr.  2015;7(5):912-21. doi: 10.1080/19420862.2015.1054585. PMID: 26018774 
  3. High-throughput sequencing analysis of post-liver transplantation HCV E2 glycoprotein evolution in the presence and absence of neutralizing monoclonal antibody. Babcock GJ, Iyer S, Smith HL, Wang Y, Rowley K, Ambrosino DM, Zamore PD, Pierce BG, Molrine DC, Weng Z. PLoS One. 2014;9(6):e100325. doi:0.1371/journal.pone.0100325. PMID: 24956119 
  4. Resolving self-association of a therapeutic antibody by formulation optimization and molecular approaches. Casaz P, Boucher E, Wollacott R, Pierce BG, Rivera R, Sedic M, Ozturk S, Thomas WD Jr, Wang Y.  2014;6(6):1533-9. doi: 10.4161/19420862.2014.975658. PMID: 25484044
  5. Identification of a human monoclonal antibody to replace equine diphtheria antitoxin for treatment of diphtheria intoxication. Sevigny LM, Booth BJ, Rowley KJ, Leav BA, Cheslock PS, Garrity KA, Sloan SE, Thomas W Jr, Babcock GJ, Wang Y. Infect Immun. 2013 Nov;81(11):3992-4000. doi: 10.1128/IAI.00462-13. PMID: 23940209
  6. Identification of human monoclonal antibodies specific for human SOD1 recognizing distinct epitopes and forms of SOD1. Broering TJ, Wang H, Boatright NK, Wang Y, Baptista K, Shayan G, Garrity KA, Kayatekin C, Bosco DA, Matthews CR, Ambrosino DM, Xu Z, Babcock GJ. PLoS One. 2013;8(4):e61210. doi: 10.1371/journal.pone.0061210. PMID: 23613814
  7. Human monoclonal antibody MBL-HCV1 delays HCV viral rebound following liver transplantation: a randomized controlled study. Chung RT, Gordon FD, Curry MP, Schiano TD, Emre S, Corey K, Markmann JF, Hertl M, Pomposelli JJ, Pomfret EA, Florman S, Schilsky M, Broering TJ, Finberg RW, Szabo G, Zamore PD, Khettry U,Babcock GJ, Ambrosino DM, Leav B, Leney M, Smith HL, Molrine DC.Am J Transplant. 2013 Apr;13(4):1047-1054. doi: 10.1111/ajt.12083. PMID: 23356386 
  8. Analytical characterization of a monoclonal antibody therapeutic reveals a three-light chain species that is efficiently removed using hydrophobic interaction chromatography. Wollacott RB, Casaz PL, Morin TJ, Zhu HL, Anderson RS, Babcock GJ, Que J, Thomas WD Jr, Ozturk SS.MAbs. 2013 Nov-Dec;5(6):925-35. doi: 10.4161/mabs.26192. PMID: 23995619
  9. Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees. Morin TJ, Broering TJ, Leav BA, Blair BM, Rowley KJ, Boucher EN, Wang Y, Cheslock PS, Knauber M, Olsen DB, Ludmerer SW, Szabo G, Finberg RW, Purcell RH, Lanford RE, Ambrosino DM, Molrine DC, Babcock GJ.  PLoS Pathog. 2012;8(8):e1002895. doi: 10.1371/journal.ppat.1002895.PMID: 22952447
  10. G glycoprotein amino acid residues required for human monoclonal antibody RAB1 neutralization are conserved in rabies virus street isolates. Wang Y, Rowley KJ, Booth BJ, Sloan SE, Ambrosino DM, Babcock GJ.  Antiviral Res. 2011 Aug;91(2):187-94. doi: 10.1016/j.antiviral.2011.06.002. PMID: 21693135 
  11. Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI). Leav BA, Blair B, Leney M, Knauber M, Reilly C, Lowy I, Gerding DN, Kelly CP, Katchar K, Baxter R, Ambrosino D, Molrine D.Vaccine. 2010 Jan 22;28(4):965-9. doi: 10.1016/j.vaccine. PMID: 19941990 
  12. Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virus. Broering TJ, Garrity KA, Boatright NK, Sloan SE, Sandor F, Thomas WD Jr, Szabo G, Finberg RW, Ambrosino DM,Babcock GJ.J Virol. 2009 Dec;83(23):12473-82. doi: 10.1128/JVI.01138-09. PMID: 19759151 
  13. Identification and characterization of a human monoclonal antibody that potently neutralizes a broad panel of rabiesvirus isolates. Sloan SE, Hanlon C, Weldon W, Niezgoda M, Blanton J, Self J, Rowley KJ, Mandell RB, Babcock GJ, Thomas WD Jr, Rupprecht CE, Ambrosino DM.Vaccine. 2007 Apr 12;25(15):2800-10. doi: 10.1016/j.vaccine. PMID: 17240489 
  14. Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice. Roberts A, Thomas WD, Guarner J, Lamirande EW,Babcock GJ, Greenough TC, Vogel L, Hayes N, Sullivan JL, Zaki S, Subbarao K, Ambrosino DM.J Infect Dis. 2006 Mar 1;193(5):685-92. doi: 10.1086/500143. PMID: 16453264 
  15. Human monoclonal antibodies directed against toxins A and B prevent Clostridium difficile-induced mortality in hamsters. Babcock GJ, Broering TJ, Hernandez HJ, Mandell RB, Donahue K, Boatright N, Stack AM, Lowy I, Graziano R, Molrine D, Ambrosino DM, Thomas WD Jr.Infect Immun. 2006 Nov;74(11):6339-47. doi: 10.1128/IAI.00982-06. PMID: 16966409 
  16. Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): identification of neutralizing and antibodies reactive to S, N, M and E viral proteins. Tripp RA, Haynes LM, Moore D, Anderson B, Tamin A, Harcourt BH, Jones LP, Yilla M,Babcock GJ, Greenough T, Ambrosino DM, Alvarez R, Callaway J, Cavitt S, Kamrud K, Alterson H, Smith J, Harcourt JL, Miao C, Razdan R, Comer JA, Rollin PE, Ksiazek TG, Sanchez A, Rota PA, Bellini WJ, Anderson LJ.J Virol Methods. 2005 Sep;128(1-2):21-8. doi: 10.1016/j.jviromet. PMID: 15885812 
  17. Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters.Greenough TC,Babcock GJ, Roberts A, Hernandez HJ, Thomas WD Jr, Coccia JA, Graziano RF, Srinivasan M, Lowy I, Finberg RW, Subbarao K, Vogel L, Somasundaran M, Luzuriaga K, Sullivan JL, Ambrosino DM.J Infect Dis. 2005 Feb 15;191(4):507-14. doi: 10.1086/427242. PMID: 15655773
  18. Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor. Babcock GJ, Esshaki DJ, Thomas WD Jr, Ambrosino DM.J Virol. 2004 May;78(9):4552-60. doi: 10.1128/jvi.78.9.4552-4560.2004.PMID: 15078936