Research Focus: Host defense against bacterial and viral respiratory pathogens with an emphasis on tuberculosis

• Immunometabolism of tuberculosis and tuberculosis-diabetes interaction
• Host-directed tuberculosis therapy
• Post-tuberculosis lung disease

Representative Publications

• Smulan, L. J., Martinez, N., Kiritsy, M. C., Kativhu, C., Cavallo, K., Sassetti, C. M., Singhal, A., Remold, H. G., & Kornfeld, H. (2021). Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death. mBio, 12(1), e03140-20. 
  
  
• Böhme, J., Martinez, N., Li, S., Lee, A., Marzuki, M., Tizazu, A. M., Ackart, D., Frenkel, J. H., Todd, A., Lachmandas, E., Lum, J., Shihui, F., Ng, T. P., Lee, B., Larbi, A., Netea, M. G., Basaraba, R., van Crevel, R., Newell, E., Kornfeld, H., … Singhal, A. (2020). Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits. Nature communications, 11(1), 5225. 
  
  
• Kornfeld, H., Sahukar, S. B., Procter-Gray, E., Kumar, N. P., West, K., Kane, K., Natarajan, M., Li, W., Babu, S., & Viswanathan, V. (2020). Impact of Diabetes and Low Body Mass Index on Tuberculosis Treatment Outcomes. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 71(9), e392–e398.
  
  
• Martinez, N., Cheng, C. Y., Ketheesan, N., Cullen, A., Tang, Y., Lum, J., West, K., Poidinger, M., Guertin, D. A., Singhal, A., & Kornfeld, H. (2019). mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis. EBioMedicine, 45, 314–327. 
  
  

More Publications

Join our Lab

The Kornfeld Lab is Hiring! New R01 funding will support an open Postdoctoral Fellowship position for research in TB immunometabolism and host-directed therapy.  We also have an open position for a Research Associate. Please contact Dr. Hardy Kornfeld if you are interested.