Publications
Lee N*^, Park SJ, Lange M, Tseyang T, Doshi MB, Kim TY, Song Y, Kim DI, Greer PL, Olzmann JA, Spinelli JB, Kim D^. Selenium reduction of ubiquinone via SQOR suppresses ferroptosis. Nature Metab. 2024 Feb 13; 6:343-358 (*equal contribution; ^co-corresponding)
(Featured in: Selenium abandons selenoproteins to inhibit ferroptosis rapidly. Nature Metab. 2024 Feb 13)
Doshi MB, Lee N, Tseyang T, Ponomarova O, Goel HL, Spears ME, Li R, Zhu LJ, Ashwood C, Simin K, Jang C, Mercurio AM, Walhout AJM, Spinelli JB, Kim D. Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells. Nature. 2023 Oct 25; 623: 625-632.
(Featured in: UXS1: A sweet spot for cell death. Nature Rev. Cancer. 2023 Nov 29)
(Featured in: Toxic UDPGA accumulation is a metabolite vulnerability of cancer cells. Cancer Discovery. 2023 Nov 10)
Spears ME, Lee N, Hwang S, Park SJ, Carlisle AE, Li R, Doshi MB, Armando AM, Gao J, Simin K, Zhu LJ, Greer PL, Quehenberger O, Torres EM, Kim D. De novo sphingolipid biosynthesis necessitates detoxification in cancer cells. Cell Reports. 2022 Sep 27; 40(13): 111415.
Lee N, Kim D. Toxic metabolites and inborn errors of amino acid metabolism: what one informs about the other. Metabolites. 2022 Jun 8; 12(6):527. Review.
Lee N, Carlisle AE, Kim D. Examining xCT-mediated selenium uptake and selenoprotein production capacity in cells. Methods Enzymol. 2022; 662:1-24
Lee N, Carlisle AE, Peppers A, Park SJ, Doshi MB, Spears ME, Kim D. xCT-driven expression of GPX4 determines sensitivity of breast cancer cells to ferroptosis inducers. Antioxidants. 2021 Feb 20; 10(2), 317
Carlisle AE*, Lee N*, Matthew-Onabanjo AN, Spears ME, Park SJ, Youkana D, Doshi MB, Peppers A, Li R, Joseph AB, Smith M, Simin K, Zhu LJ, Greer PL, Shaw LM, Kim D. Selenium detoxification is required for cancer-cell survival. Nature Metab. 2020 Jul 2; 2(7):603-611 (*equal contribution)
(Featured in: A micronutrient with major effects on cancer cell viability. Nature Metab. 2020 July 6; 2:564-565.)
Lee N, Spears ME, Carlisle AE, Kim D. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 July 24; 39, 5709-5720. Review.
Matthew-Onabanjo AN, Janusis J, Mercado-Matos J, Carlisle AE, Kim D, Levine F, Cruz-Gordillo P, Richards R, Lee MJ, Shaw LM. Beclin 1 promotes endosome recruitment of hepatocyte growth factor tyrosine kinase substrate (HRS) to suppress tumor proliferation. Cancer Res. 2019 Nov 15; 80(2):249-262
Wang C, Choi HJ, Kim SJ, Desai A, Lee N, Kim D, Bae Y, Lee K. Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging. Nat Commun. 2018 Apr 27;9(1):1688
Lee N, Kim D. Cancer Metabolism: Fueling more than just growth. Mol Cells. 2016 Dec 31; 39(12): 847–854. Review.
Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato R, Chudnovsky Y, Pacold ME, Chen WW, Shelton LM, Gui DY, Kwon M, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 2015 Apr 16;520(7547):363-367.
Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, Nishimura R, Sakata N, Fine HA, Carpenter AE, Silver SJ, Verhaak RG, Califano A, Young RA, Ligon KL, Mellinghoff IK, Root DE, Sabatini DM, Hahn WC, Chheda MG. ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Cell Reports. 2014 Jan 30;6(2):313-24.
Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, and Sabatini DM. Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer, Nature, 2011 Aug 18;476(7360):346-50.
Sheen JH, Zoncu R, Kim D, Sabatini DM. Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo. Cancer Cell. 2011 May 17;19(5):613-628.
Graff J, Kim D, Dobbin MM, Tsai LH. Epigenetic regulation of gene expression in physiological and pathological brain processes. Physiol. Rev. 2011 Apr;91(2):603-49. Review.
Kim D, Tsai LH. Bridging Physiology and Pathology in AD. Cell. 2009 June 12;137(6):997-1000. Review.
Kim D, Frank CL, Dobbin MM, Tu W, Peng PL, Guan JS, Lee BH, Moy LY, Giusti P, Broodie N, Mazitschek R, Delalle I, Haggarty SJ, Neve RL, Lu YM, Tsai LH. Deregulation of HDAC1 by p25/cdk5 in neurotoxicity. Neuron. 2008 Dec 10;60(5):803-817.
Kim D*, Nguyen MD*, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007 Jul 11;26(13):3169-79. (*equal contribution)
Cruz JC*, Kim D*, Moy LY, Dobbin MM, Sun X, Bronson RT, Tsai LH. p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo. J Neurosci. 2006 Oct 11;26(41):10536-41. (*equal contribution)