Signaling Pathways in Development and Tumor Suppression

Failure to properly regulate cell differentiation and proliferation can lead to aberrant  development and/or tumorigenesis. Our laboratory generates genetically modified mice to investigate the regulatory pathways that govern normal cell growth and development, and to examine how alteration of these pathways can lead to cancer. We are presently focusing on mechanisms that regulate the expression and function of tumor suppressor proteins. Our research centers on three areas of investigation: Regulation of the p53 tumor suppressor, Wnt signaling in development and cancer, and Epigenetic regulation of tumor suppressor functions. In addition, the Jones Lab maintains the UMass Chan Mouse User Group webpage (http://inside.umassmed.edu/MUG/index.aspx), and Stephen Jones is the Director of the UMass Chan Transgenic Animal Modeling Core (http://umassmed.edu/tkomouse).

 

Induced pluripotent stem cells generated from adult mouse tail fibroblasts