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Selected from Over 185 Peer-Reviewed Publications

Receiving More Than 36,400 Citations

Reviews

Kim, J.K. Endothelial nuclear factor kB in obesity and aging: Is endothelial nuclear factor kB a master regulator of inflammation and insulin resistance. Circulation. 2012 Mar 6;125(9):1081-3. PMID: 22302839. DOI: 10.1161/CIRCULATIONAHA.111.090134.

Gray, S. and Kim, J.K. New insights into insulin resistance in the diabetic heart. Trends Endocrinol Metab. 2011 Oct;22(10):394-403. PMID: 21680199. PMCID: PMC3183400. DOI: 10.1016/j/tem/2011.05.001. Cover article

Kim, J.K. Inflammation and insulin resistance: an old story with new ideas. Korean Diabetes J. 2010 Jun;34(3):137-45. PMID: 20617073. PMCID: PMC2898926. DOI: 10.4093/kdj.2010.34.3.137.

Kim, J.K. Hyperinsulinemic-euglycemic clamp to assess insulin sensitivity in vivo. Methods Mol Biol. 2009;560:221-38. PMID: 19504253. DOI: 10.1007/978-1-59745-448-3_15.

Kim, J.K. Fat uses a TOLL-road to connect inflammation and diabetes. Cell Metab. 2006 Dec;4(6):417-9. PMID: 17141623. DOI: 10.1016/j.cmet.2006.11.008.

Understanding the Role of Inflammation and Insulin Resistance in Metabolic Liver Disease

Friedline, R.H., Noh, H.L., Suk, S., Albusharif, M., Dagdeviren, S., Saengnipanthkul, S., Kim, B., Kim, A.M., Kim, L.H., Tauer, L.A., Baez Torres, N.M., Choi, S., Kim, B.-Y., Rao, S.D., Kasina, K., Sun, C., Toles, B.J., Zhou, C., Li, Z., Benoit, V.M., Patel, P.R., Zheng, D.X.T., Inashima, K., Beaverson, A., Hu, X., Tran, D.A., Muller, W., Greiner, D.L., Mullen, A.C., Lee, K.W., and Kim, J.K. IFNgamma-IL12 axis regulates intercellular crosstalk in metabolic dysfunction-associated steatotic liver disease. Nature Communications 15:5506 (2024)

Saegnipanthkul, S., Noh, H.L., Friedline, R.H., Suk, S., Choi, S., Acosta, N.K., Tran, D.A., Hu, X., Inashima, K., Kim, A.M., Lee, K.W., and Kim, J.K. Maternal exposure to high-fat diet during pregnancy and lactation predisposes normal weight offspring mice to develop hepatic inflammation and insulin resistance. Physiological Reports 9:e14811 (2021)

Understanding the Mechanism of Development of Type 2 Diabetes and Its Treatment

Hong, E.G., Ko, H.J., Cho, Y.R., Kim, H.J., Ma, Z., Yu, T.Y., Friedline, R.H., Kurt-Jones, E., Finberg, R., Fischer, M.A., Granger, E.L., Norbury, C.C., Hauschka, S.D., Philbrick, W.M., Lee, C.G., Elias, J.A., and Kim, J.K. Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes. 2009 Nov;58(11):2525-35. PMID: 19690064. PMCID: PMC2768157. DOI: 10.2337/db08-1261. Cited by 361.

Kim, H.J., Higashimori, T., Park, S.Y., Choi, H., Dong, J., Kim, Y.J., Noh, H.L., Cho, Y.R., Cline, G., Kim, Y.B., and Kim, J.K. Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes. 2004 Apr;53(4):1060-7. PMID:15047622. DOI: 10.2337/diabetes.53.4.1060. Cited by 591.

Kim, J.K., Kim, Y.-J., Fillmore, J.J., Chen, Y., Moore, I., Lee, J., Yuan, M., Li, Z.W., Karin, M., Perret, P., Shoelson, S.E., and Shulman, G.I. Prevention of fat-induced insulin resistance by salicylate. J Clin Invest. 2001 Aug;108(3):437-46. PMID: 11489937. PMCID: PMC209353. DOI: 10-1172/JCI11559. Cited by 916.

Kim, J.K., Fillmore, J.J., Chen, Y., Yu, C., Moore, I.K., Pypaert, M., Lutz, E.P., Kako, Y., Velez-Carrasco, W., Goldberg, I.J., Breslow, J.L., and Shulman, G.I. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci USA. 2001 Jun 19;98(13):7522-7. PMID: 11390966. PMCID: PMC34701. DOI: 10.1073/pnas.121164498. Cited by 757.

Identifying the Role of Obesity-Mediated Inflammation in Type 2 Diabetes and Aging

Kim, J.H., Lee, E., Friedline, R.H., Suk, S., Jung, D.Y., Dagdeviren, S., Hu, X., Inashima, K., Noh, H.L., Kwon, J.Y., Nambu, A., Huh, J.R., Han, M.S., Davis, R.J., Lee, A.S., Lee, K.W., and Kim, J.K. Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity. FASEB J. 2018 Apr;32(4):2292-2304. PMID: 29242277. PMCID: PMC6207176. DOI: 10.1096/fj.201701017R. Cited by 12.

Dagdeviren, S., Jung, D.Y., Friedline, R.H., Noh, H.L., Kim, J.H., Patel, P.R., Tsitsilianos, N., Inashima, K., Tran, D.A., Hu, X., Loubato, M.M., Craige, S.M., Kwon, J.Y., Lee, K.W., and Kim, J.K. IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle. FASEB J. 2017 Feb;31(2):701-710. PMID: 27811060. PMCID: PMC5240661. DOI: 10.1096/ fj.201600832R. Cited by 45.

Dagdeviren, S., Jung, D.Y., Lee, E., Friedline, R.H., Noh, H.L., Kim, J.H., Patel, P.R., Tsitsilianos, N., Tsitsilianos, A.V., Tran, D.A., Tsougranis, G.H., Kearns, C.C., Uong, C.P., Kwon, J.Y., Muller, W., Lee, K.W., and Kim, J.K. Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity-Mediated Inflammation and Insulin Resistance. Mol Cell Biol. 2016 Nov 14;36(23):2956-2966. PMID: 27644327. PMCID: PMC5108883. DIO: 10.1128/MCB.00181-16. Cited by 38.

Jung, D.Y., Ko, H.J., Lichtman, E.I., Lee, E., Lawton, E., Ong, H., Yu, K., Azuma, Y., Friedline, R.H., Lee, K.W., and Kim, J.K. Short-term weight loss attenuates local tissue inflammation and improves insulin sensitivity without affecting adipose inflammation in obese mice. Am J Physiol Endocrinol Metab. 2013 May 1;304(9): E964-76. PMID: 23482446. PMCID: PMC3651644. DOI: 10.1152/ajpendo.00462.2012. Cited by 37.

Delineating the Causal Relationship Between Obesity and Type 2 Diabetes

Cho, Y.-R., Kim, H.-J., Park, S.-Y., Ko, H.J., Hong, E.-G., Higashimori, T., Zhang, Z., Jung, D.Y., Ola, M.S., LaNoue, K.F., Leiter, E.H., and Kim, J.K. Hyperglycemia, maturity-onset obesity, and insulin resistance in NONcNZO10/LtJ males, a new mouse model of type 2 diabetes. Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E327-36. PMID: 17616608. DOI: 10.1152/ajpendo.00376.2006. Cited by 52.

Park, S.-Y., Cho, Y.-R., Kim, H.-J., Higashimori, T., Danton, C., Lee, M.-K., Dey, A., Rothermel, B., Kim, Y.-B., Kalinowski, A., Russell, K.S., and Kim, J.K. Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice. Diabetes. 2005 Dec;54(12):3530-40. PMID: 16306372. DOI: 10.2337/ diabetes.54. 12.3530. Cited by 310.

Park, S.-Y., Kim, H.-J., Wang, S., Higashimori, T., Dong, J., Kim, Y.-J., Cline, G.W., Li, H., Prentki, M., Shulman, G.I., Mitchell, G.A., and Kim, J.K. Hormone-sensitive lipase knockout mice have increased hepatic insulin resistance and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart. Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E30-9. PMID: 15701680. DOI: 10.1152/ajpendo.00251.2004. Cited by 106.

Kim, J.K., Michael, M.D., Previs, S.F., Peroni, O.D., Mauvais-Jarvis, F., Neschen, S., Kahn, B.B., Kahn, C.R., and Shulman, G.I. Redistribution of substrates to adipose tissue in mice with selective insulin resistance in muscle promotes obesity. J Clin Invest. 2000 Jun;105(12):1791-7. PMID: 10862794. PMCID: PMC378504. DOI: 10.1172/JCI8305. Cited by 333.

Defining the Molecular Mechanism of Obesity-Mediated Insulin Resistance

Lee, E., Jung, D.Y., Patel, P.R., Kim, J.H., Hu, X., Lee, Y., Azuma, Y., Wang, H.-F., Tsitsilianos, N., Shafiq, U., Kwon, J.Y., Lee, H.J., Lee, K.W., and Kim. J.K. Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance. FASEB J. 2015 Aug;29(8):3182-92. PMID: 25888600. PMCID: PMC4511197. DOI: 10.1096/fj.14-268300. Cited by 82.

Zhang, Z., Zhang, W., Jung, D.Y., Ko, H.J., Lee, Y.J., Friedline, R., Lee, E., Jun, J., Ma, Z., Kim, F., Tsitsilianos, N., Chapman, K., Morrison, A., Cooper, M.P., Miller, M.A., and

Kim, J.K. TRPM2 Ca²⁺ channel regulates energy balance and glucose metabolism. Am J Physiol Endocrinol Metab. 2012 Apr 1;302(7):E807-16. PMID: 22275755. PMCID: PMC3330711. DOI: 10.1152/ajpendo.00239-2011. Cited by 57.

Kim, J.K., Fillmore, J.J., Sunshine, M.J., Albrecht, B., Higashimori, T., Kim, D.-W., Liu, Z.-X., Soos, T.J., Cline, G.W., O’Brien, W.R., Littman, D.R., and Shulman, G.I. PKC-theta knockout mice are protected from fat-induced insulin resistance. J Clin Invest. 2004 Sep;114(6):823-7. PMID: 15372106. PMCID: PMC516267. DOI: 10.1172/JCI22230. Cited by 575.

Kim, J.K., Gavrilova, O., Chen, Y., Reitman, M.L., and Shulman, G.I. Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J Biol Chem. 2000 Mar 24;275(12):8456-60. PMID: 10722680. DOI: 10.1074:jbc.275.12.8456. Cited by 476.

Elucidating the Role of Nutrient Stress and Inflammation in Diabetic Heart Disease

Hong, E.-G., Kim, B.W., Jung, D.Y., Kim, J.H., Yu, T., Da Silva, W.S., Friedline, R.H., Bianco, S.D., Seslar, S.P., Wakimoto, H., Berul, C.I., Russell, K.S., Lee, K.W., Larsen, P.R., Bianco, A.C., and Kim, J.K. Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice. Endocrinology. 2013 Oct;154(10):3937-46. PMID: 23861374. PMCID: PMC4411365. DOI: 10.1210/en.2012-2261. Cited by 16.

Ko, H.J., Zhang, Z., Jung, D.Y., Jun, J.Y., Ma, Z., Jones, K., Chan, S.Y., and Kim, J.K. Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart. Diabetes. 2009 Nov;58(11):2536-46. PMID: 19690060. PMCID: PMC2768176. DOI: 10.2337/db08-1361. Cited by 145.

Hong, E.-G., Jung, D.Y., Ko, H.J., Zhang, Z., Ma, Z., Jun, J.Y., Kim, J.H., Sumner, A.D., Vary, T.C., Gardner, T.W., Bronson, S.K., and Kim, J.K. Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling. Am J Physiol Endocrinol Metab. 2007 Dec;293(6): E1687-96. PMID: 17911348. DOI: 10.1152/ajpendo.00256.2007. Cited by 71.

Park, S.-Y., Cho, Y.-R., Finck, B.N., Kim, H.-J., Higashimori, T., Hong, E.-G., Lee, M.-K., Danton, C., Deshmukh, S., Cline, G.W., Wu J.J., Bennett, A.M., Rothermel, B., Kalinowski, A., Russell, K.S., Kim, Y.-B., Kelly, D.P., and Kim, J.K. Cardiac-specific overexpression of peroxisome proliferator-activated receptor-a causes insulin resistance in heart and liver. Diabetes. 2005 Sep;54(9):2514-24. PMID: 16123338. DOI: 10.2337/diabetes.54.9.2514. Cited by 125.

Collaborating with Academic and Industry Investigators for Diabetes and Obesity Research and Identifying Potential Therapeutic Targets to Treat Type 2 Diabetes

Goodman, R.P., Markhard, A.L., Shah, H., Sharma, R., Skinner, O.S., Clish, C.B., Deik, A., Patgiri, A., Hsu, Y.-H., Masia, R., Noh, H.L., Suk, S., Goldberger, O., Hirschhorn, J., Yallen, G., Kim, J.K., and Mootha, V.K. Hepatic NADH reductive stress underlies common variation in metabolic traits. Nature. 2020 Jul;583(7814):122-126. PMID: 32461692. PMCID: PMC7536642. DOI: 10.1038/s41586-020-2337-2. Cited by 6.

Thielen, L.A., Chen, J., Jing, G., Moukha-Chafiq, O., Xi, G., Jo, S.H., Grayson, T.B., Lu, B., Li, P., Augeli-Szafran, C.E., Suto, M.J., Kanke, M., Sethupathy, P., Kim, J.K., and Shalev, A. Identification of an anti-diabetic, orally available small molecule that regulates TXNIP expression and glucagon action. Cell Metab. 2020 Sep 1;32(3): 353-365. PMID: 32726606. PMCID: PMC7501995. DOI: 10.1016/j.cmet.2020.07.002. Cited by 5.

Batista, T.M., Garcia-Martin, R., Cai, W., Konishi, M., O’Neill, B.T., Sakaguchi, M., Kim, J.H., Jung, D.Y., Kim, J.K., and Kahn, C.R. Multi-dimensional transcriptional remodeling by physiological insulin in vivo. Cell Rep. 2019 Mar 19;26(12):3429-3443. PMID: 30893613. PMCID: PMC6543850. DOI: 10.1016/j.celrep.2019.02.081. Cited by 25.

Hurtado del Pozo, C., Ruiz, H.H., Arivazhagan, L., Aranda, J.F., Shim, C., Daya, P., Derk, J., MacLean, M., Le, M., Frye, L., Friedline, R.H., Noh, H.L., Kim, J.K., Friedman, R.A., Ramasamy, R., and Schmidt, A.M. A receptor of the immunoglobulin superfamily regulates adaptive thermogenesis. Cell Rep. 2019 Jul 16;28(3):773-791. PMID: 31315054. PMCID: PMC6686683. DOI: 10.1016/j.celrep.2019.06.061. Cited by 11.

Kim, M.-S., Krawczyk, S.A., Doridot, L., Fowler, A.J., Wang, J.X., Trauger, S.A., Noh, H.-L., Kang, H.J., Meissen, J., Blatnik, M., Kim, J.K., Lai, M., and Herman, M.A. ChREBP regulates fructose-induced glucose production independently of insulin signaling. J Clin Invest. 2016 Nov 1;126(11):4372-4386. PMID: 27669460. PMCID: PMC5096918. DOI: 10.1172/JCI81993. Cited by 106.

Meng, Z.-X., Li, S., Wang, L., Ko, H.J., Lee, Y., Jung, D.Y., Okutsu, M., Yan, Z., Kim, J.K., and Lin, J.D. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated AKT activation. Nature Med. 2013 May;19(5):640-5. PMID: 23563706. PMCID: PMC3650110. DOI: 10.1038/nm.3144. Cited by 92.

Lee, N.K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J.-D., Confavreux, C., Dacquin, R., Mee, P.J., McKee, M., Jung, D.Y., Zhang, Z., Kim, J.K., Mauvais-Jarvis, F., Ducy, P., and Karsenty, G. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007 Aug 10;130(3):456-69. PMID: 17693256. PMCID: PMC2013746. DOI: 10.1016/j.cell.2007.05.047. Cited by 2,450.

Cho, H., Mu, J., Kim, J.K., Thorvaldsen, J.L., Chu, Q., Crenshaw III, E.B., Kaestner, K.H., Bartolomei, M.S., Shulman, G.I., and Birnbaum, M.J. Insulin resistance and diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBb). Science. 2001 Jun 1;292(5522):1728-31. PMID: 11387480. DOI: 10.1126/science.292.5522. 1728. Cited by 2,093.