Reviews and Commentaries

He, F. and Jacobson, A. Eukaryotic mRNA decapping factors: molecular mechanisms and activity. FEBS J. https://doi:10.1111/febs.16626, 2022.

Goodwin, E., Jacobson, A., Weetall, M., Graci, J.D., Welch, E.M., O’Keefe, K., and Peltz, S.W. Dual mechanism of action of PTC299 and other DHODH inhibitors in suppressing SARS-CoV-2 replication and cellular cytokine storms. J. Cytokine Biol. 6: 10037, 2021.

Celik, A., He, F., and Jacobson, A. NMD monitors translational fidelity 24/7. Current Genet. 63: 1007-1010, 2017.

Jacobson, A. Methods to our madness. RNA 21: 529-530, 2015. 

Celik, A., Kervestin, S., and Jacobson, A. NMD: at the crossroads between translation termination and ribosome recycling. Biochimie 114: 2-9, 2015

He, F. and Jacobson, A. Nonsense-mediated mRNA decay: degradation of defective transcripts is only part of the story. Ann. Rev. Genetics 49: 339-366, 2015.

Roy, B. and Jacobson, A. The intimate relationships of mRNA decay and translation. Trends Genet. 29: 691-699, 2013

Peltz, S.W., Welch, E. M., Morsy, M., and Jacobson, A. Ataluren as an agent for therapeutic nonsense suppression. Ann. Rev. Med. 64: 407-425, 2013.

Kervestin, S. and Jacobson, A. NMD: a multifaceted response to premature translational termination. Nature Rev. Mol. Cell Biol. 13: 700-712, 2012.

Peltz, S.W., Welch, E.M., Trotta, C.R., Davis, T., and Jacobson, A. Targeting post-transcriptional control for drug discovery. RNA Biol. 6: 329-334, 2009.

Jacobson, A. and Izaurralde, E. Nonsense-mediated mRNA decay: from yeast to metazoans. In: Translational Control in Biology and Medicine (Eds.: Sonenberg, N., Mathews, M., and Hershey, J.), Cold Spring Harbor Laboratory Press, NY, pp. 655-687, 2007. 

Amrani, N., Sachs, M.S., and Jacobson, A. Early nonsense: mRNA decay solves a translational problem. Nature Rev. Mol. Cell Biol. 7: 415-425, 2006.

Amrani, N. and Jacobson, A. All termination events are not equal: premature termination in yeast is aberrant and triggers NMD. In: Nonsense-mediated mRNA decay (Editor: L.E. Maquat), Landes Bioscience, Texas, pp. 15-25, 2006.

He, F. and Jacobson, A. Endogenous substrates of the yeast NMD pathway. In: Nonsense-mediated mRNA decay (Editor: L.E. Maquat), Landes Bioscience, Texas, pp. 27-41, 2006.

Amrani, N., Dong, S., He, F., Ganesan, R., Ghosh, S., Kervestin, S., Li, C., Mangus, D.A., Spatrick, P., and Jacobson, A. Aberrant termination triggers nonsense-mediated mRNA decay. Biochem. Soc. Transact. 34: 39-42, 2006.

Mangus, D.A., Evans, M.C., and Jacobson, A. Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression. Genome Biol. 4: 223.1-223.14, 2003.

Jacobson, A. and Peltz, S.W. Destabilization of nonsense-containing transcripts in Saccharomyces cerevisiae. In: Translational Control, Second Edition (Eds: N. Sonenberg, J.W.B. Hershey and M.B. Mathews), Cold Spring Harbor Laboratory Press, N.Y., pp. 827-847, 2000.

Hennigan, A.N. and Jacobson, A. A genetic approach to mapping coding region determinants of mRNA instability in yeast. In: mRNA Formation and Function (Ed.: Joel D. Richter), Academic Press, San Diego, pp. 149-161, 1997.

Jacobson, A. Poly(A) metabolism and translation: the closed loop model. In: Translational Control (Eds: J.W.B. Hershey, M.B. Mathews, and N. Sonenberg), Cold Spring Harbor Laboratory Press, N.Y. pp. 451-480, 1996.

Jacobson, A. and Peltz, S.W. Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells. Ann. Rev. Biochem. 65: 693-740, 1996. 

Peltz, S.W., He, F., Welch, E., and Jacobson, A. Nonsense-mediated mRNA decay in yeast. Prog. Nucleic Acid Res. Mol. Biol. 47: 271-298, 1994.

Peltz, S.W. and Jacobson, A. mRNA turnover in Saccharomyces cerevisiae. In: Control of mRNA Stability (Eds: J. Belasco & G. Brawerman), Academic Press, pp. 291-328, 1993. 

Peltz, S.W., Trotta, C., Feng, H., Brown, A., Donahue, J., Welch, E., and Jacobson, A. Identification of the cis-acting sequences and trans-acting factors involved in nonsense-mediated mRNA decay. In: Protein Synthesis and Targeting in Yeast (Eds: A. Brown, M. Tuite, and J. McCarthy), Springer-Verlag, pp. 1-10, 1993.

Munroe, D. and Jacobson, A. Poly(A) is a 3' enhancer of translational initiation. In Structure, Function, and Evolution of Ribosomes (Ed. W. Hill), ASM Press, pp. 299-305, 1990. 

Munroe, D. and Jacobson, A. Tales of poly(A)-a review. Gene 91: 151-158, 1990.

Munroe, D. and Jacobson, A.  Involvement of 3'-poly(A) tracts in protein synthesis: a role in mRNP assembly. In Molecular Biology of RNA (Ed. T.R. Cech), Alan R. Liss, Inc., pp. 257-269, 1989. 

Steel, L.F. and Jacobson, A. Post-transcriptional regulation of ribosomal protein gene expression during development in Dictyostelium discoideum. Devel. Genetics 9: 421-434, 1988. 

Manrow, R.E., Shapiro, R.A., Herrick, D., Steel, L.F., Blinder, D., and Jacobson, A. Regulation of mRNA stability and the poly(A) problem in Dictyostelium discoideum. Devel. Genetics 9: 403-419, 1988. 

Jacobson, A. and H.F. Lodish.  Genetic control of development of the cellular slime mold, Dictyostelium discoideum, Ann. Rev. Genetics 9: 145-185, 1975. 

Lodish, H.F., A. Jacobson, R.A. Firtel, T. Alton and J. Tuchman.  Synthesis of messenger RNA and chromosome structure of the cellular slime mold.  Proc. Natl. Acad. Sci. U.S. 71: 5103-5108, 1974.

Firtel, R.A., A. Jacobson, J. Tuchman and H.F. Lodish.  Gene activity during development of the cellular slime mold, Dictyostelium discoideum.  Genetics 78: 355-372, 1974.

Lodish, H.F., R.A. Firtel and A. Jacobson.  Transcription and structure of the genome of the cellular slime mold, Dictyostelium discoideum.  Cold Spring Harbor Symp. Quant. Biol. 38: 899-914, 1973.

Lodish, H.F. and A. Jacobson.  Translational control of protein synthesis in eukaryotic cells: Is there tissue or species specificity of the translational apparatus?  Develop. Biol. 27: 283-285, 1972.