NMD
Ganesan, R., Mangkalaphiban, K., Baker, R.E., He, F., and Jacobson, A. Ribosome-bound Upf1 forms distinct 80S complexes and conducts mRNA surveillance. RNA 28: 1621-1642, 2022.
Ganesan, R., Mangkalaphiban, K., Baker, R.E., He, F., and Jacobson, A. Progressive polysomal association of Upf1, Upf2, and Upf3 as ribosomes traverse mRNA coding regions. bioRxiv: https://doi.org/10.1101/2021.12.03.471156, 2021.
Wu, C., Roy, B., He, F., Yan, K., Jacobson, A. Poly(A)-binding protein regulates the efficiency of translation termination. Cell Reports 33: 108399, 2020.
Celik, A., Baker, R., He, F., and Jacobson, A. High resolution profiling of NMD substrates in yeast reveals translational fidelity as a basis for substrate selection. RNA 23: 735-748, 2017.
He, F. and Jacobson, A. Control of mRNA decapping by positive and negative regulatory elements in the C-terminal domain of Dcp2. RNA 21: 1633-1647, 2015.
Min, E., Roy, B., Amrani, N., He, F., and Jacobson, A. Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit. RNA 19: 1105-1115, 2013.
He, F., Ganesan, R., and Jacobson, A. Intra- and intermolecular regulatory interactions in Upf1, the RNA helicase central to NMD in yeast. Mol. Cell. Biol. 33: 4672-4684, 2013.
Johansson, M.J.O. and Jacobson, A. Nonsense-mediated mRNA decay maintains translational fidelity by limiting magnesium uptake. Genes & Devel. 24: 1491-1495, 2010.
Ghosh, S., Ganesan, R., Amrani, N., and Jacobson, A. Translational competence of ribosomes released from a premature termination codon is modulated by NMD factors. RNA 16: 1832-1847, 2010.
Johansson, M. J.O., He, F., Spatrick, P., Li, C., and Jacobson, A. Association of yeast Upf1p with direct substrates of the NMD pathway. Proc. Natl. Acad. Sci. USA 104: 20872-20877, 2007.
Gaba, A., Jacobson, A., and Sachs, M.S. Ribosome occupancy of the CPA1 upstream open reading frame termination codon modulates nonsense-mediated mRNA decay. Molec. Cell 20: 449-460, 2005.
Amrani, N., Ganesan, R., Kervestin, S., Mangus, D., Ghosh, S., and Jacobson, A. A faux 3’-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay. Nature 432: 112-118, 2004.
He, F., Li, X., Spatrick, P., Casillo, R., Dong, S., and Jacobson, A. Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast. Molec. Cell 12: 1439-1452, 2003.
Maderazo, A.B., Belk, J.P., He, F., and Jacobson, A. Nonsense-containing mRNAs that accumulate in the absence of a functional NMD pathway are destabilized rapidly upon its restitution. Mol. Cell. Biol. 23: 842-851, 2003.
He, F. and Jacobson, A. Upf1p, Nmd2p, and Upf3p regulate the decapping and exonucleolytic degradation of both nonsense-containing mRNAs and wild-type mRNAs Mol. Cell. Biol. 21: 1515-1530, 2001.
Maderazo, A.B., He, F., Mangus, D.A., and Jacobson, A. Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p. Mol. Cell. Biol. 20: 4591-4603, 2000.
Bhattacharya, A., Czaplinski, K., Trifillis, P., He, F., Jacobson, A. and Peltz, S.W. Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay. RNA 6: 1226-1235, 2000.
Welch, E.M. and Jacobson, A. An internal open reading frame triggers nonsense-mediated mRNA decay of the yeast SPT10 mRNA. EMBO J. 18: 6134-6145, 1999.
He, F., Brown, A.H., and Jacobson, A. Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway. Mol. Cell. Biol. 17: 1580-1594, 1997.
Zhang, S., Welch, E.M., Hagan, K., Brown, A.H., Peltz, S.W., and Jacobson, A. Polysome-associated mRNAs are substrates for the nonsense-mediated mRNA decay pathway in Saccharomyces cerevisiae RNA 3: 234-244, 1997.
He, F., Brown, A.H., and Jacobson, A. Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast. RNA 2: 153-170, 1996.
He, F. and Jacobson, A. Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes & Devel. 9: 437-454, 1995.
He, F., Peltz, S.W., Donahue, J.L., Rosbash, M., and Jacobson, A. Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant. Proc. Natl. Acad. Sci. USA 90: 7034-7038, 1993.
Peltz, S.W., Brown, A.H., and Jacobson, A. mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor. Genes & Devel. 7: 1737-1754, 1993.
Leeds, P., Peltz, S.W., Jacobson, A., and Culbertson, M.R. The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. Genes & Devel. 5: 2303-2314, 1991.