Current Lab Members

Education:

BSc: Cellular and Molecular Biology, Shahid Chamran University, Ahvaz, Iran
MS: Biotechnology, Alzahra University, Tehran, Iran 
PhD: Medical Biotechnology, Tarbiat Modares University, Tehran, Iran (2014-)
PhD: Immunology, UMass Chan Medical School, Worcester, MA (2019-)

A limiting factor in the widespread application of gene therapy is the induction of an immune response. In systemic Adeno Associated Virus (AAV) gene therapy, there is an immune response to both the AAV vehicle and the introduced transgene. My project focuses on generation of chimeric antigen receptor regulatory T cells (CAR-Tregs) to suppress an immune response against AAV gene therapy and the introduced transgene.

Education: BS - Biology, UMass Dartmouth

Joinied the Flotte Lab in 2020

Education:

PhD - Molecular and Cell Biology, Nanyang Technological University

MS - Biotechnology, University of Calcutta

BS - Microbiology, University of Calcutta

Ishani also serves as the Events Director of Central Mass chapter of AWIS (Association for Women in Science)

Joined the Flotte Lab in 2020

Education: BA - Chemistry, College of the Holy Cross

Joinied the Flotte Lab in 2019

Education: BA - Biology, College of the Holy Cross

Joined the Flotte Lab in 2019

Education: MS - Biochemistry, Jilin University

BS - Chemistry, Jilin University 

Working on recombinant adeno-associated virus (AAV) gene therapy vectors for alpha-1-antitrypsin deficiency (AAT). Focusing on dual-function AAV vector to augment wild-type(M-AAT) with simultaneous mutate AAT( Z-AAT) knockdown in a transgenic mouse model. My other focus is on NSG-PiZ  humanized mouse model to provide a platform for future studies of both cell based and genetic therapies of AAT deficiency

Joined the Flotte Lab in 2001