Cardiovascular and Surgical Core Services

In Vivo

Left Anterior Descending (LAD) Coronary Artery Ligation

• Myocardial infarction (MI) Animal model induces sustained ischemia to myocardium, mimicking the pathophysiology of human myocardial infarction.
• Ischemia-reperfusion injury (MIR) caused by reperfusion following ischemia. This model mimics myocardial injury after angioplasty and bypass surgery.

Transverse aortic constriction (TAC)

• Surgical narrowing of the aortic arch or abdominal aorta to induce left ventricular pressure-volume overload; reversible as a model of hypertrophic regression.

Hind Limb Ischemia

• Femoral artery ligation provides a simple model of ischemic tissue. The advantage of this model is the easily of accessed femoral artery and low mortality rate.
• Single or double Ligation of the femoral artery to induce angiogenesis/collateralization. With laser Doppler flow measurement.

Carotid Artery Ligation

• An arterial injury model that initiates a vascular remodeling response involving primarily vascular smooth muscle cells
• To understand the formation and development ab aneurysm and identification of potential medical treatments. Mini-pump implantation with angiotensin II (ANGII)

Abdominal Aortic Aneurysm (AAA)

• To understand the formation and development aneurysms and identification of potential medical treatments.
• Mini-pump implantation with angiotensin II (ANGII)

Parabiosis

•  Surgically connecting two animals we can prove that the feedback system in one animal is circulated and affects the second animal via blood and plasma exchange.

Atherosclerosis 

• Atherosclerosis is an Inflammatory disease characterized by the development atherosclerotic plaques. These plaques lead to narrowing and hardening of the arterial lumen.

Wire Myography 

• To Study Vascular Tone and Vascular Structure of Isolated Mouse Arteries

Renal Ischemia or Renal Ischemia Reperfusion Injury

• To Study the complex responses of the kidney to acute injury

Other Services:

• Other surgical models as needed, Please inquire as to your specific needs
• Nephrectomy 
• Orchiectomy 
• Ovariectomy 
• Splenectomy 
• Vasectomy 
• Vasovasostomy
• Wound Healing
• Minipump Placement, or Removal/Replacement
• Acute Vascular catheterization (Carotid, Jugular or Femoral vesels)
• Compound delivery-Gavage, Lavage, Nasal instalations, IP, SC, IV, ID injections
• Long Term Alternate Diet Studies
• Noninvasive echocardiographic studies with or without contrast
• EchoMRI Whole Body composition analysis
• Rodent Blood Pressure Monitoring studies (CODA)
• Micro CT Scan, Micro PET Scan
• Animal Model development via KO creation
• Glucose/insulin tolerance test (GTT/ITT)
• Sac, tissue harvest and preservation 
• Histology Services
• Alzet mini pumps
• PEC collection and culture
• SVF and lipid collection
• Rodent irradiation and bone marrow implant
• Denervation: Surgical and chemical
• Treadmill exercise-standard and exhaustive
• Sx training

Please inquire with you needs.