Rodent Models and Preclinical Research Methods
In Vivo
Left Anterior Descending (LAD) Coronary Artery Ligation
- Myocardial infarction (MI) Animal model induces sustained ischemia to myocardium, mimicking the pathophysiology of human myocardial infarction.
- Ischemia-reperfusion injury (MIR) caused by reperfusion following ischemia. This model mimics myocardial injury after angioplasty and bypass surgery.
Transverse aortic constriction (TAC)
- Surgical narrowing of the aortic arch or abdominal aorta to induce left ventricular pressure-volume overload; reversible as a model of hypertrophic regression.
- Femoral artery ligation provides a simple model of ischemic tissue. The advantage of this model is the easily of accessed femoral artery and low mortality rate.
- Single or double Ligation of the femoral artery to induce angiogenesis/collateralization. With laser Doppler flow measurement.
- An arterial injury model that initiates a vascular remodeling response involving primarily vascular smooth muscle cells
- To understand the formation and development ab aneurysm and identification of potential medical treatments. Mini-pump implantation with angiotensin II (ANGII)
Abdominal Aortic Aneurysm (AAA)
- To understand the formation and development aneurysms and identification of potential medical treatments.
- Mini-pump implantation with angiotensin II (ANGII)
- Surgically connecting two animals we can prove that the feedback system in one animal is circulated and affects the second animal via blood and plasma exchange.
- Atherosclerosis is an Inflammatory disease characterized by the development atherosclerotic plaques. These plaques lead to narrowing and hardening of the arterial lumen.
- To Study Vascular Tone and Vascular Structure of Isolated Mouse Arteries
Renal Ischemia or Renal Ischemia Reperfusion Injury
- To Study the complex responses of the kidney to acute injury
Other Services:
- Other surgical models as needed, Please inquire as to your specific needs
- Nephrectomy
- Orchiectomy
- Ovariectomy
- Splenectomy
- Vasectomy
- Vasovasostomy
- Wound Healing
- Nerv Crush Injury
- Adipose Denervation - Chemical(6HODA) and Surgical
- Minipump Placement, or Removal/Replacement
- Acute Vascular catheterization (Carotid, Jugular or Femoral vesels)
- Compound delivery-Gavage, Lavage, Nasal instalations, IP, SC, IV, ID injections
- Long Term Alternate Diet Studies
- Noninvasive echocardiographic studies with or without contrast
- EchoMRI Whole Body composition analysis
- Rodent Blood Pressure Monitoring studies (CODA)
- Micro CT Scan, Micro PET Scan
- Animal Model development via KO creation
- Glucose/insulin tolerance test (GTT/ITT)
- Sac, tissue harvest and preservation
- Histology Services
- Alzet mini pumps
- PEC collection and culture
- SVF and lipid collection
- Rodent irradiation and bone marrow implant
- Denervation: Surgical and chemical
- Treadmill exercise-standard and exhaustive
- Sx training
Please inquire with you needs.