Welcome to the Lim Lab in the Division of Innate Immunity

Research Focus: Understanding human genetic variation and environmental factors (viruses and other pathogens) in neurological diseases

• Developing human induced pluripotent stem cell based neuroinflammation systems for high-throughput assays
• Identifying human-pathogen interactions for therapeutic target and biomarker discoveries
• Developing multiplexed, high-throughput genetic screens to reverse disease-associated molecular and cellular pathology

Representative publications

• Olson M, Dawes P, Murray L, Barton N, Sundstrom J, Orszulak A, Chigas S, Tran K, Aylward A, Caliandro M, Riechers SP, Afshari K, Wang Q, Garber M, Humphries F, Orzalli M, Golenbock D, Heneka M, Oh HS, Church G, Young-Pearse T, Knipe D, Readhead B, Chan Y, Lim ET. Development of a high-throughput, quantitative platform using human cerebral organoids to study virus-induced neuroinflammation in Alzheimer’s disease. bioRxiv. 2024 Mar 23. 
  
  
• Sundstrom J, Vanderleeden E, Barton N, Redick S, Dawes P, Murray L, Olson M, Tran K, Chigas S, Orszulak A, Church G, Readhead B, Oh HS, Harlan, D, Knipe D, Wang J, Chan Y, & Lim ET. Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer’s Disease and Autoimmune Diseases. Cells. 2024; 13(23):1978.
   
• Barton N, Tran K, Olson M, Deshpande M, Radu I, Francis N, Kurban M, Orszulak A, Chigas S, Sundstrom J, Dawes P, Murray L, Ionete C, Lim ET, Hemond C, Chan Y. Unbiased multiplex antigen screening of Cerebrospinal Fluid detects microbial and autoantigenic epitopes associated with Multiple Sclerosis. bioRxiv. 2024 Mar 23.
  
  

More Publications

Join our Lab

We are looking for research assistants, bioinformaticians and postdocs to join our dynamic research group! Please reach out to Elaine (elaine.lim@umassmed.edu) if interested. Thanks!