Select Publications

Selected Review Articles

Czech, M.P. (1989) Signal Transmission by the Insulin Like Growth Factors. Cell 59, 235-238.

Czech, M.P. (2000) PIP2 and PIP3: Complex roles at the cell surface. Cell 100, 603-606.

Guilherme A., Virbasius J.V., Puri V., Czech M.P. (2008) Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol.  9(5):367-77. PMC2886982.

Czech, M.P., Aouadi, M. and Tesz, G.J. (2011). RNAi-based therapeutic strategies for metabolic disease. Nature Reviews in Endocrinology 7(8), 473-484. PMID: 21502982.

Czech, M.P. (2017) Insulin Resistance in type 2 Diabetes and Obesity Nature Medicine 23 (7). 804-814 PMID: 28697184

A complete list of my published work can be found in 

 My Bibliography

Identification of subunit  configurations of the receptors for insulin and the insulin-like growth factors

Pilch, P.F. and Czech, M.P. (1979). Interaction of Cross-Linking Agents with the Insulin Effector System of Isolated Fat Cells.  Covalent Linkage of 125I-Insulin to a Plasma Membrane Receptor Protein of 140,000 Daltons. J. Biol. Chem., 254: 3375-3381. PMID: 429356.

Massague, J and Czech, M.P. (1982). The Subunit Structures of Two Distinct Receptors for Insulin-Like Growth Factors I and II and Their Relationship to the Insulin Receptor.  J. Biol. Chem., 257: 5038-5045. PMID: 6279656.

MacDonald. R.G., Pfeffer, S.R., Coussens, L., Tepper, M.A., Brocklebank, C.M., Mole, J.E., Anderson, J.K., Chen, E., Czech, M.P. and Ullrich, A. (1988) A Single Receptor Binds both Insulin-like Growth Factor II and Mannose-6-Phosphate.  Science, 239: 1134-1137. PMID: 2964083.

Identification of a key downstream target of insulin-stimulated PIP3 generation

Klarlund, J., Guilherme, A., Holik, J.J., Virbasius, J.V., Chawla, A., Czech, M.P. (1997). Signaling by 3,4,5-Phosphoinositide   through   Proteins   Containing   Pleckstrin   and   Sec7   Homology   Domains. Science, 275, 1927-1933. PMID: 9072969.

Lietzke, S.E., Bose, S., Cronin, T., Klarlund, J., Chawla, A., Czech, M.P., Lambright, D.G.(2000) Structural Basis of 3-Phosphoinositide Recognition by Pleckstrin Homology Domains.  Molecular Cell 6: 385-394. PMID: 10983985.

Jiang, Z., Zhou, Q.L., Coleman, K.A., Chouinard, M., Bose, A., Czech, M.P.(2003) Insulin Signaling Through Akt/PKB Analyzed by siRNA-mediated Gene Silencing. Proc Natl Acad Sci U S A, 100(13):7569-7564. PMC164627.

Identification of lipid droplet proteins and mechanisms of lipid storage

Puri, V., Ranjit, S., Konda, S. Nicoloro, S.M., Straubhaar J, Chawla, A., Chouinard, M., Lin, C., Burkart A, Corvera, S., Perugini, R.A., Czech, M.P.(2008) Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc. Nat. Acad. Sci. USA 105(22): 7833-7838. PMC2409392.

Rubio-Cabezas O, Puri V, Murano I, Saudek V, Semple RK, Dash S, Hyden CS, Bottomley W, Vigouroux C, Magré J, Raymond-Barker P, Murgatroyd PR, Chawla A, Skepper JN, Chatterjee VK, Suliman S, Patch AM, Agarwal AK, Garg A, Barroso I, Cinti S, Czech MP, Argente J, O'Rahilly S,Savage DB; LD Screening Consortium.(2009) Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC. EMBO Mol Med. 1(5) 280-7. PMC2891108.

DiStefano MT, Danai LV, Roth Flach RJ, Chawla A, Pedersen DJ, Guilherme A, Czech MP. (2015) The lipid droplet protein Hypoxia-inducible gene 2 promotes hepatic triglyceride deposition by inhibiting lipolysis. J Biol Chem., 290 (24) 15175-84. PMID: 25922078.

Development of siRNA delivery technology for research and therapeutic strategies

Powelka AM, Seth, A, Virbasius, JV, Kiskinis, E, Nicoloro, SM, Tang, X, Straubhaar, J, Cherniack, AD, Parker, MG, Czech, MP. (2006) Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. Journal of Clinical Investigation. 116(1):125-136. PMID 16374519.

Roth Flach RJ, Skoura A, Matevossian A, Danai LV, Zheng W, Cortes C, Bhattacharya SK, Aouadi M, Hagan N, Yawe JC, Vangala P, Menendez LG, Cooper MP, Fitzgibbons TP, Buckbinder L, Czech MP. (2015) Endothelial protein kinase Map4k4 promotes vascular inflammation and atherosclerosis.  Nature Communications. 6:8995. PMID 26688060.

Aouadi M, Tencerova M, Vangala P, Yawe JC, Nicoloro SM, Amano SU, Cohen JL, Czech MP. (2013) Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice. Proc Natl Acad Sci U S A. 110(20): 8278-8283. PMC3657808.

Jourdan T, Godlewski G, Cinar R, Bertola A, Szanda G, Liu J, Tam J, Han T, Mukhopadhyay B, Skarulis MC, Ju C, Aouadi M, Czech MP, Kunos G. (2013) Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Nature Medicine. 19(9):1132-1140. PMC4050982.