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Publications
Total:
displaying 10 out of
100
results
Protein Citrullination in Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases
lunes, diciembre 23, 2024
Author(s):
Issa O Yusuf,Webb Camille,Paul R Thompson,Zuoshang Xu
Direct delivery of Cas-embedded cytosine base editors as ribonucleoprotein complexes for efficient and accurate editing of clinically relevant targets
lunes, diciembre 16, 2024
Author(s):
Jeong Min Lee,Jing Zeng,Pengpeng Liu,My Anh Nguyen,Diego Suchenski Loustaunau,Daniel E Bauer,Nese Kurt Yilmaz,Scot A Wolfe,Celia A Schiffer
High-Throughput Screening of More Than 30,000 Compounds for Anthelmintics against Gastrointestinal Nematode Parasites
lunes, diciembre 09, 2024
Author(s):
Mostafa A Elfawal,Emily Goetz,Youmie Kim,Paulina Chen,Sergey N Savinov,Leonard Barasa,Paul R Thompson,Raffi V Aroian
Cryo-EM structure of histidyl-tRNA synthetase-like domain reveals activating crossed helices at the core of GCN2
lunes, diciembre 02, 2024
Author(s):
Kristina Solorio-Kirpichyan,Xiao Fan,Dmitrij Golovenko,Andrei A Korostelev,Nieng Yan,Alexei Korennykh
Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding
viernes, noviembre 22, 2024
Author(s):
Ella W Mathews,Sydney R Coffey,Annette Gärtner,Jillian Belgrad,Robert M Bragg,Daniel O'Reilly,Jeffrey P Cantle,Cassandra McHugh,Ashley Summers,Joachim Fentz,Tom Schwagarus,Antje Cornelius,Ioannis Lingos,Zoe Burch,Marina Kovalenko,Marissa A Andrew,C Frank Bennett,Holly B Kordasiewicz,Deanna M Marchionini,Hilary Wilkinson,Thomas F Vogt,Ricardo M Pinto,Anastasia Khvorova,David Howland,Vanessa C Wheeler,Jeffrey B Carroll
Efficient convergent synthesis of 1,3-diazepinone nucleosides by ring-closing metathesis and direct glycosylation
jueves, noviembre 21, 2024
Author(s):
Adam K Hedger,Jonathan Findell,Dinesh S Barak,Celia A Schiffer,Jonathan K Watts,Akbar Ali
Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation
lunes, noviembre 18, 2024
Author(s):
Rachael Miller,Joseph Paquette,Alexandra Barker,Ellen Sapp,Nicholas McHugh,Brianna Bramato,Nozomi Yamada,Julia Alterman,Dimas Echeveria,Ken Yamada,Jonathan Watts,Christelle Anaclet,Marian DiFiglia,Anastasia Khvorova,Neil Aronin
Quantifying and mitigating motor phenotypes induced by antisense oligonucleotides in the central nervous system
sábado, octubre 26, 2024
Author(s):
Michael P Moazami,Julia M Rembetsy-Brown,Samantha L Sarli,Holly R McEachern,Feng Wang,Masahiro Ohara,Atish Wagh,Karen Kelly,Pranathi Meda Krishnamurthy,Alexandra Weiss,Miklos Marosfoi,Robert M King,Mona Motwani,Heather Gray-Edwards,Katherine A Fitzgerald,Robert H Brown,Jonathan K Watts
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
lunes, octubre 21, 2024
Author(s):
Luis M García-Marín,Adrian I Campos,Santiago Diaz-Torres,Jill A Rabinowitz,Zuriel Ceja,Brittany L Mitchell,Katrina L Grasby,Jackson G Thorp,Ingrid Agartz,Saud Alhusaini,David Ames,Philippe Amouyel,Ole A Andreassen,Konstantinos Arfanakis,Alejandro Arias-Vasquez,Nicola J Armstrong,Lavinia Athanasiu,Mark E Bastin,Alexa S Beiser,David A Bennett,Joshua C Bis,Marco P M Boks,Dorret I Boomsma,Henry Brodaty,Rachel M Brouwer,Jan K Buitelaar,Ralph Burkhardt,Wiepke Cahn,Vince D Calhoun,Owen T Carmichael,Mallar Chakravarty,Qiang Chen,Christopher R K Ching,Sven Cichon,Benedicto Crespo-Facorro,Fabrice Crivello,Anders M Dale,George Davey Smith,Eco J C de Geus,Philip L De Jager,Greig I de Zubicaray,Stéphanie Debette,Charles DeCarli,Chantal Depondt,Sylvane Desrivières,Srdjan Djurovic,Stefan Ehrlich,Susanne Erk,Thomas Espeseth,Guillén Fernández,Irina Filippi,Simon E Fisher,Debra A Fleischman,Evan Fletcher,Myriam Fornage,Andreas J Forstner,Clyde Francks,Barbara Franke,Tian Ge,Aaron L Goldman,Hans J Grabe,Robert C Green,Oliver Grimm,Nynke A Groenewold,Oliver Gruber,Vilmundur Gudnason,Asta K Håberg,Unn K Haukvik,Andreas Heinz,Derrek P Hibar,Saima Hilal,Jayandra J Himali,Beng-Choon Ho,David F Hoehn,Pieter J Hoekstra,Edith Hofer,Wolfgang Hoffmann,Avram J Holmes,Georg Homuth,Norbert Hosten,M Kamran Ikram,Jonathan C Ipser,Clifford R Jack,Neda Jahanshad,Erik G Jönsson,Rene S Kahn,Ryota Kanai,Marieke Klein,Maria J Knol,Lenore J Launer,Stephen M Lawrie,Stephanie Le Hellard,Phil H Lee,Hervé Lemaître,Shuo Li,David C M Liewald,Honghuang Lin,W T Longstreth,Oscar L Lopez,Michelle Luciano,Pauline Maillard,Andre F Marquand,Nicholas G Martin,Jean-Luc Martinot,Karen A Mather,Venkata S Mattay,Katie L McMahon,Patrizia Mecocci,Ingrid Melle,Andreas Meyer-Lindenberg,Nazanin Mirza-Schreiber,Yuri Milaneschi,Thomas H Mosley,Thomas W Mühleisen,Bertram Müller-Myhsok,Susana Muñoz Maniega,Matthias Nauck,Kwangsik Nho,Wiro J Niessen,Markus M Nöthen,Paul A Nyquist,Jaap Oosterlaan,Massimo Pandolfo,Tomas Paus,Zdenka Pausova,Brenda W J H Penninx,G Bruce Pike,Bruce M Psaty,Benno Pütz,Simone Reppermund,Marcella D Rietschel,Shannon L Risacher,Nina Romanczuk-Seiferth,Rafael Romero-Garcia,Gennady V Roshchupkin,Jerome I Rotter,Perminder S Sachdev,Philipp G Sämann,Arvin Saremi,Muralidharan Sargurupremraj,Andrew J Saykin,Lianne Schmaal,Helena Schmidt,Reinhold Schmidt,Peter R Schofield,Markus Scholz,Gunter Schumann,Emanuel Schwarz,Li Shen,Jean Shin,Sanjay M Sisodiya,Albert V Smith,Jordan W Smoller,Hilkka S Soininen,Vidar M Steen,Dan J Stein,Jason L Stein,Sophia I Thomopoulos,Arthur W Toga,Diana Tordesillas-Gutiérrez,Julian N Trollor,Maria C Valdes-Hernandez,Dennis van T Ent,Hans van Bokhoven,Dennis van der Meer,Nic J A van der Wee,Javier Vázquez-Bourgon,Dick J Veltman,Meike W Vernooij,Arno Villringer,Louis N Vinke,Henry Völzke,Henrik Walter,Joanna M Wardlaw,Daniel R Weinberger,Michael W Weiner,Wei Wen,Lars T Westlye,Eric Westman,Tonya White,A Veronica Witte,Christiane Wolf,Jingyun Yang,Marcel P Zwiers,M Arfan Ikram,Sudha Seshadri,Paul M Thompson,Claudia L Satizabal,Sarah E Medland,Miguel E Rentería
AFM41a: A Novel PAD2 Inhibitor for Sepsis Treatment-Efficacy and Mechanism
lunes, octubre 21, 2024
Author(s):
Tao Dong,Leonard Barasa,Xin Yu,Wenlu Ouyang,Liujiazi Shao,Chao Quan,Su He Wang,Jifeng Zhang,Morgan Salmon,Allan Tsung,Hasan B Alam,Jianjie Ma,Paul R Thompson,Yongqing Li
A Hydrophobic Core Stabilizes the Residual Structure in the RRM2 Intermediate State of the ALS-linked Protein TDP-43
sábado, octubre 19, 2024
Author(s):
Brian C Mackness,Brittany R Morgan,Laura M Deveau,Sagar V Kathuria,Jill A Zitzewitz,Francesca Massi
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
lunes, octubre 07, 2024
Author(s):
Luis M García-Marín,Adrian I Campos,Santiago Diaz-Torres,Jill A Rabinowitz,Zuriel Ceja,Brittany L Mitchell,Katrina L Grasby,Jackson G Thorp,Ingrid Agartz,Saud Alhusaini,David Ames,Philippe Amouyel,Ole A Andreassen,Konstantinos Arfanakis,Alejandro Arias Vasquez,Nicola J Armstrong,Lavinia Athanasiu,Mark E Bastin,Alexa S Beiser,David A Bennett,Joshua C Bis,Marco Pm Boks,Dorret I Boomsma,Henry Brodaty,Rachel M Brouwer,Jan K Buitelaar,Ralph Burkhardt,Wiepke Cahn,Vince D Calhoun,Owen T Carmichael,Mallar Chakravarty,Qiang Chen,Christopher R K Ching,Sven Cichon,Benedicto Crespo-Facorro,Fabrice Crivello,Anders M Dale,George Davey Smith,Eco Jc de Geus,Philip L De Jager,Greig I de Zubicaray,Stéphanie Debette,Charles DeCarli,Chantal Depondt,Sylvane Desrivières,Srdjan Djurovic,Stefan Ehrlich,Susanne Erk,Thomas Espeseth,Guillén Fernández,Irina Filippi,Simon E Fisher,Debra A Fleischman,Evan Fletcher,Myriam Fornage,Andreas J Forstner,Clyde Francks,Barbara Franke,Tian Ge,Aaron L Goldman,Hans J Grabe,Robert C Green,Oliver Grimm,Nynke A Groenewold,Oliver Gruber,Vilmundur Gudnason,Asta K Håberg,Unn K Haukvik,Andreas Heinz,Derrek P Hibar,Saima Hilal,Jayandra J Himali,Beng-Choon Ho,David F Hoehn,Pieter J Hoekstra,Edith Hofer,Wolfgang Hoffmann,Avram J Holmes,Georg Homuth,Norbert Hosten,M Kamran Ikram,Jonathan C Ipser,Clifford R Jack,Neda Jahanshad,Erik G Jönsson,Rene S Kahn,Ryota Kanai,Marieke Klein,Maria J Knol,Lenore J Launer,Stephen M Lawrie,Stephanie Le Hellard,Phil H Lee,Hervé Lemaître,Shuo Li,David Cm Liewald,Honghuang Lin,W T Longstreth,Oscar L Lopez,Michelle Luciano,Pauline Maillard,Andre F Marquand,Nicholas G Martin,Jean-Luc Martinot,Karen A Mather,Venkata S Mattay,Katie L McMahon,Patrizia Mecocci,Ingrid Melle,Andreas Meyer-Lindenberg,Nazanin Mirza-Schreiber,Yuri Milaneschi,Thomas H Mosley,Thomas W Mühleisen,Bertram Müller-Myhsok,Susana Muñoz Maniega,Matthias Nauck,Kwangsik Nho,Wiro J Niessen,Markus M Nöthen,Paul A Nyquist,Jaap Oosterlaan,Massimo Pandolfo,Tomas Paus,Zdenka Pausova,Brenda Wjh Penninx,G Bruce Pike,Bruce M Psaty,Benno Pütz,Simone Reppermund,Marcella D Rietschel,Shannon L Risacher,Nina Romanczuk-Seiferth,Rafael Romero-Garcia,Gennady V Roshchupkin,Jerome I Rotter,Perminder S Sachdev,Philipp G Sämann,Arvin Saremi,Muralidharan Sargurupremraj,Andrew J Saykin,Lianne Schmaal,Helena Schmidt,Reinhold Schmidt,Peter R Schofield,Markus Scholz,Gunter Schumann,Emanuel Schwarz,Li Shen,Jean Shin,Sanjay M Sisodiya,Albert V Smith,Jordan W Smoller,Hilkka S Soininen,Vidar M Steen,Dan J Stein,Jason L Stein,Sophia I Thomopoulos,Arthur W Toga,Diana Tordesillas-Gutiérrez,Julian N Trollor,Maria C Valdes-Hernandez,Dennis van 't Ent,Hans van Bokhoven,Dennis van der Meer,Nic Ja van der Wee,Javier Vázquez-Bourgon,Dick J Veltman,Meike W Vernooij,Arno Villringer,Louis N Vinke,Henry Völzke,Henrik Walter,Joanna M Wardlaw,Daniel R Weinberger,Michael W Weiner,Wei Wen,Lars T Westlye,Eric Westman,Tonya White,A Veronica Witte,Christiane Wolf,Jingyun Yang,Marcel P Zwiers,M Arfan Ikram,Sudha Seshadri,Paul M Thompson,Claudia L Satizabal,Sarah E Medland,Miguel E Rentería
Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance
sábado, septiembre 28, 2024
Author(s):
Vincent N Azzolino,Ala M Shaqra,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques
jueves, septiembre 26, 2024
Author(s):
Joanna Zikos,Gabriela M Webb,Helen L Wu,Jason S Reed,Jennifer Watanabe,Jodie L Usachenko,Ala M Shaqra,Celia A Schiffer,Koen K A Van Rompay,Jonah B Sacha,Diogo M Magnani
Increasing intracellular dNTP levels improves prime editing efficiency
miércoles, septiembre 25, 2024
Author(s):
Pengpeng Liu,Karthikeyan Ponnienselvan,Thomas Nyalile,Sarah Oikemus,Anya T Joynt,Sukanya Iyer,Karen Kelly,Dongsheng Guo,Pyae P Kyawe,Emma Vanderleeden,Sambra D Redick,Lei Huang,Zexiang Chen,Jeong Min Lee,Celia A Schiffer,David M Harlan,Jennifer P Wang,Charles P Emerson,Nathan D Lawson,Jonathan K Watts,Erik J Sontheimer,Jeremy Luban,Scot A Wolfe
Structure and Dynamics of the CCCH-Type Tandem Zinc Finger Domain of POS-1 and Implications for RNA Binding Specificity
miércoles, septiembre 25, 2024
Author(s):
Asli Ertekin,Brittany R Morgan,Sean P Ryder,Francesca Massi
Next generation APOBEC3 inhibitors: Optimally designed for potency and nuclease stability
lunes, septiembre 16, 2024
Author(s):
Adam K Hedger,Wazo Myint,Jeong Min Lee,Diego Suchenski-Loustaunau,Vanivilasini Balachandran,Ala M Shaqra,Nese Kurt-Yilmaz,Jonathan K Watts,Hiroshi Matsuo,Celia A Schiffer
Identification of selective and non-selective C9ORF72 targeting in vivo active siRNAs
jueves, septiembre 05, 2024
Author(s):
James W Gilbert,Zachary Kennedy,Bruno M D C Godinho,Ashley Summers,Alexandra Weiss,Dimas Echeverria,Brianna Bramato,Nicholas McHugh,David Cooper,Ken Yamada,Matthew Hassler,Hélène Tran,Fen Biao Gao,Robert H Brown,Anastasia Khvorova
Near Sequence Homology Does Not Guarantee siRNA Cross-Species Efficacy
martes, agosto 27, 2024
Author(s):
Iris Valeria Rivera Flores,Kathryn Monopoli,Samuel Jackson,Dimas Echeverria,Daniel O'Reilly,Robert H Brown,Anastasia Khvorova
Miniaturized Fab' imaging probe derived from a clinical antibody: Characterization and imaging in CRISPRi-attenuated mammary tumor models
lunes, agosto 26, 2024
Author(s):
Suresh Gupta,Rahul Pal,Eric J Schmidt,Murali Krishnamoorthy,Anita Leporati,Anand T N Kumar,Alexei Bogdanov
Long wavelength near-infrared and red light-driven consecutive photo-induced electron transfer for highly effective photoredox catalysis
viernes, agosto 23, 2024
Author(s):
Le Zeng,Ling Huang,Zhi Huang,Tomoyasu Mani,Kai Huang,Chunying Duan,Gang Han
Enhancing siRNA efficacy in vivo with extended nucleic acid backbones
jueves, agosto 01, 2024
Author(s):
Ken Yamada,Vignesh N Hariharan,Jillian Caiazzi,Rachael Miller,Chantal M Ferguson,Ellen Sapp,Hassan H Fakih,Qi Tang,Nozomi Yamada,Raymond C Furgal,Joseph D Paquette,Annabelle Biscans,Brianna M Bramato,Nicholas McHugh,Ashley Summers,Clemens Lochmann,Bruno M D C Godinho,Samuel Hildebrand,Samuel O Jackson,Dimas Echeverria,Matthew R Hassler,Julia F Alterman,Marian DiFiglia,Neil Aronin,Anastasia Khvorova
Calcineurin promotes adaptation to chronic stress through two distinct mechanisms
miércoles, julio 31, 2024
Author(s):
Mackenzie J Flynn,Nicholas W Harper,Rui Li,Lihua Julie Zhu,Michael J Lee,Jennifer A Benanti
Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy
sábado, julio 20, 2024
Author(s):
Ozen Leylek,Megan E Honeywell,Michael J Lee,Michael T Hemann,Gulnihal Ozcan
Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference
sábado, julio 20, 2024
Author(s):
Courtney M Kloske,Michael E Belloy,Elizabeth E Blue,Gregory R Bowman,Maria C Carrillo,Xiaoying Chen,Ornit Chiba-Falek,Albert A Davis,Gilbert Di Paolo,Francesca Garretti,David Gate,Lesley R Golden,Jay W Heinecke,Joachim Herz,Yadong Huang,Costantino Iadecola,Lance A Johnson,Takahisa Kanekiyo,Celeste M Karch,Anastasia Khvorova,Sascha J Koppes-den Hertog,Bruce T Lamb,Paige E Lawler,Yann Le Guen,Alexandra Litvinchuk,Chia-Chen Liu,Simin Mahinrad,Edoardo Marcora,Claudia Marino,Danny M Michaelson,Justin J Miller,Josh M Morganti,Priyanka S Narayan,Michel S Naslavsky,Marlies Oosthoek,Kapil V Ramachandran,Abhirami Ramakrishnan,Ana-Caroline Raulin,Aiko Robert,Rasha N M Saleh,Claire Sexton,Nilomi Shah,Francis Shue,Isabel J Sible,Andrea Soranno,Michael R Strickland,Julia Tcw,Manon Thierry,Li-Huei Tsai,Ryan A Tuckey,Jason D Ulrich,Rik van der Kant,Na Wang,Cheryl L Wellington,Stacie C Weninger,Hussein N Yassine,Na Zhao,Guojun Bu,Alison M Goate,David M Holtzman
mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo
jueves, julio 18, 2024
Author(s):
Sarah Allen,Daniel O'Reilly,Rachael Miller,Ellen Sapp,Ashley Summers,Joseph Paquette,Dimas Echeverria Moreno,Brianna Bramato,Nicholas McHugh,Ken Yamada,Neil Aronin,Marian DiFiglia,Anastasia Khvorova
mRNA-specific readthrough of nonsense codons by antisense oligonucleotides (R-ASOs)
martes, julio 16, 2024
Author(s):
Denis Susorov,Dimas Echeverria,Anastasia Khvorova,Andrei A Korostelev
X-ray Attenuating Vesicles with Neutrophil Extracellular Trap (NET) Specificity: Synthesis and Testing in a Model System
lunes, julio 15, 2024
Author(s):
Mark Epshtein,Matthew J Gounis,Alexei A Bogdanov
RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice
martes, julio 09, 2024
Author(s):
Alexandra Weiss,James W Gilbert,Iris Valeria Rivera Flores,Jillian Belgrad,Chantal Ferguson,Elif O Dogan,Nicholas Wightman,Kit Mocarski,Dimas Echeverria,Ashley Summers,Brianna Bramato,Nicholas McHugh,Raymond Furgal,Nozomi Yamada,David Cooper,Kathryn Monopoli,Bruno M D C Godinho,Matthew R Hassler,Ken Yamada,Paul Greer,Nils Henninger,Robert H Brown,Anastasia Khvorova
Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA
viernes, junio 28, 2024
Author(s):
Vignesh N Hariharan,Takahiro Nakamura,Minwook Shin,Qi Tang,Vyankat Sontakke,Jillian Caiazzi,Samuel Hildebrand,Anastasia Khvorova,Ken Yamada
Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation
miércoles, junio 19, 2024
Author(s):
Rachael Miller,Joseph Paquette,Alexandra Barker,Ellen Sapp,Nicholas McHugh,Brianna Bramato,Nozomi Yamada,Julia Alterman,Dimas Echeveria,Ken Yamada,Jonathan Watts,Christelle Anaclet,Marian DiFiglia,Anastasia Khvorova,Neil Aronin
Muscle-specific pyruvate kinase isoforms, PKM1 and PKM2, regulate mammalian SWI/SNF proteins and histone 3 phosphorylation during myoblast differentiation
miércoles, junio 05, 2024
Author(s):
Monserrat Olea-Flores,Tapan Sharma,Odette Verdejo-Torres,Imaru DiBartolomeo,Paul R Thompson,Teresita Padilla-Benavides,Anthony N Imbalzano
Chitosan Phytate Nanoparticles: A Synergistic Strategy for Effective Dental Caries Prevention
miércoles, mayo 15, 2024
Author(s):
Weibo Jiang,Jing Peng,Nan Jiang,Wenyi Zhang,Shuang Liu,Jianmin Li,Dengyi Duan,Yiming Li,Cheng Peng,Yongfa Yan,Yang Zhao,Gang Han
A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system
viernes, mayo 10, 2024
Author(s):
Jillian Belgrad,Qi Tang,Sam Hildebrand,Ashley Summers,Ellen Sapp,Dimas Echeverria,Dan O'Reilly,Eric Luu,Brianna Bramato,Sarah Allen,David Cooper,Julia Alterman,Ken Yamada,Neil Aronin,Marian DiFiglia,Anastasia Khvorova
Structural mechanism of angiogenin activation by the ribosome
miércoles, mayo 08, 2024
Author(s):
Anna B Loveland,Cha San Koh,Robin Ganesan,Allan Jacobson,Andrei A Korostelev
Triggered Release of Ampicillin from Metallic Implant Coatings for Combating Periprosthetic Infections
miércoles, mayo 01, 2024
Author(s):
Feiyang Chen,Jordan D Skelly,Shing-Yun Chang,Jie Song
Expanding the Potential of Neoantigen Vaccines: Harnessing Bacille Calmette-Guérin Cell-Wall-Based Nanoscale Adjuvants for Enhanced Cancer Immunotherapy
lunes, abril 29, 2024
Author(s):
Kangkang Liu,Jing Peng,Yunfei Guo,Yiming Li,Xiang Qi,Dengyi Duan,Taipeng Li,Jianmin Li,Yuanjie Niu,Gang Han,Yang Zhao
Muscle-Specific Pyruvate Kinase Isoforms, Pkm1 and Pkm2, Regulate Mammalian SWI/SNF Proteins and Histone 3 Phosphorylation During Myoblast Differentiation
lunes, abril 22, 2024
Author(s):
Monserrat Olea-Flores,Tapan Sharma,Odette Verdejo-Torres,Imaru DiBartolomeo,Paul R Thompson,Teresita Padilla-Benavides,Anthony N Imbalzano
Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo
sábado, abril 13, 2024
Author(s):
Samantha L Sarli,Hassan H Fakih,Karen Kelly,Gitali Devi,Julia M Rembetsy-Brown,Holly R McEachern,Chantal M Ferguson,Dimas Echeverria,Jonathan Lee,Jacquelyn Sousa,Hanadi F Sleiman,Anastasia Khvorova,Jonathan K Watts
More than 185 CAG repeats: a point of no return in Huntington's disease biology
lunes, abril 08, 2024
Author(s):
Jillian Belgrad,Anastasia Khvorova
Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer
jueves, abril 04, 2024
Author(s):
Alok K Mishra,Tianyi Ye,Shahid Banday,Ritesh P Thakare,Chinh Tran-To Su,Ngoc N H Pham,Amjad Ali,Ankur Kulshreshtha,Shreya Roy Chowdhury,Tessa M Simone,Kai Hu,Lihua Julie Zhu,Birgit Eisenhaber,Sara K Deibler,Karl Simin,Paul R Thompson,Michelle A Kelliher,Frank Eisenhaber,Sunil K Malonia,Michael R Green
RNAi-based drug design: considerations and future directions
miércoles, abril 03, 2024
Author(s):
Qi Tang,Anastasia Khvorova
Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
martes, abril 02, 2024
Author(s):
Kyounghee Min,Batuhan Yenilmez,Mark Kelly,Dimas Echeverria,Michael Elleby,Lawrence M Lifshitz,Naideline Raymond,Emmanouela Tsagkaraki,Shauna M Harney,Chloe DiMarzio,Hui Wang,Nicholas McHugh,Brianna Bramato,Brett Morrison,Jeffery D Rothstein,Anastasia Khvorova,Michael P Czech
Calcineurin promotes adaptation to chronic stress through two distinct mechanisms
martes, abril 02, 2024
Author(s):
Mackenzie J Flynn,Nicholas W Harper,Rui Li,Lihua Julie Zhu,Michael J Lee,Jennifer A Benanti
Triplet-triplet annihilation photon upconversion-mediated photochemical reactions
viernes, marzo 22, 2024
Author(s):
Ling Huang,Gang Han
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia
jueves, marzo 21, 2024
Author(s):
Salome Funes,Jonathan Jung,Del Hayden Gadd,Michelle Mosqueda,Jianjun Zhong,None Shankaracharya,Matthew Unger,Karly Stallworth,Debra Cameron,Melissa S Rotunno,Pepper Dawes,Megan Fowler-Magaw,Pamela J Keagle,Justin A McDonough,Sivakumar Boopathy,Miguel Sena-Esteves,Jeffrey A Nickerson,Cathleen Lutz,William C Skarnes,Elaine T Lim,Dorothy P Schafer,Francesca Massi,John E Landers,Daryl A Bosco
Nucleic Acid Therapeutics: Successes, Milestones, and Upcoming Innovation
miércoles, marzo 20, 2024
Author(s):
Jillian Belgrad,Hassan H Fakih,Anastasia Khvorova
Endogenous trans-translation structure visualizes the decoding of the first tmRNA alanine codon
martes, marzo 19, 2024
Author(s):
David Teran,Ying Zhang,Andrei A Korostelev
Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication
viernes, marzo 15, 2024
Author(s):
Jacob T Landeck,Joshua Pajak,Emily K Norman,Emma L Sedivy,Brian A Kelch
Functional genomic screens with death rate analyses reveal mechanisms of drug action
jueves, marzo 14, 2024
Author(s):
Megan E Honeywell,Marie S Isidor,Nicholas W Harper,Rachel E Fontana,Gavin A Birdsall,Peter Cruz-Gordillo,Sydney A Porto,Madison Jerome,Cameron S Fraser,Kristopher A Sarosiek,David A Guertin,Jessica B Spinelli,Michael J Lee
Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance
martes, marzo 12, 2024
Author(s):
Julia M Flynn,Sarah N Zvornicanin,Tenzin Tsepal,Ala M Shaqra,Nese Kurt Yilmaz,Weiping Jia,Stephanie Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon
EZH2 inhibition reactivates epigenetically silenced FMR1 and normalizes molecular and electrophysiological abnormalities in fragile X syndrome neurons
jueves, marzo 07, 2024
Author(s):
Minggang Fang,Sara K Deibler,Pranathi Meda Krishnamurthy,Feng Wang,Paola Rodriguez,Shahid Banday,Ching-Man Virbasius,Miguel Sena-Esteves,Jonathan K Watts,Michael R Green
Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope
sábado, febrero 17, 2024
Author(s):
Nathan Bamidele,Han Zhang,Xiaolong Dong,Haoyang Cheng,Nicholas Gaston,Hailey Feinzig,Hanbing Cao,Karen Kelly,Jonathan K Watts,Jun Xie,Guangping Gao,Erik J Sontheimer
Harmonizing the Generation and Pre-publication Stewardship of FAIR bioimage data
miércoles, febrero 14, 2024
Author(s):
Nikki Bialy,Frank Alber,Brenda Andrews,Michael Angelo,Brian Beliveau,Lacramioara Bintu,Alistair Boettiger,Ulrike Boehm,Claire M Brown,Mahmoud Bukar Maina,James J Chambers,Beth A Cimini,Kevin Eliceiri,Rachel Errington,Orestis Faklaris,Nathalie Gaudreault,Ronald N Germain,Wojtek Goscinski,David Grunwald,Michael Halter,Dorit Hanein,John W Hickey,Judith Lacoste,Alex Laude,Emma Lundberg,Jian Ma,Leonel Malacrida,Josh Moore,Glyn Nelson,Elizabeth Kathleen Neumann,Roland Nitschke,Shuichi Onami,Jaime A Pimentel,Anne L Plant,Andrea J Radtke,Bikash Sabata,Denis Schapiro,Johannes Schöneberg,Jeffrey M Spraggins,Damir Sudar,Wouter-Michiel Adrien Maria Vierdag,Niels Volkmann,Carolina Wählby,Siyuan Steven Wang,Ziv Yaniv,Caterina Strambio-De-Castillia
Multispecies-targeting siRNAs for the modulation of JAK1 in the skin
viernes, febrero 02, 2024
Author(s):
Qi Tang,Katherine Y Gross,Hassan H Fakih,Samuel O Jackson,Mohammad Zain U I Abideen,Kathryn R Monopoli,Carine Blanchard,Claire Bouix-Peter,Thibaud Portal,John E Harris,Anastasia Khvorova,Julia F Alterman
Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors
martes, enero 09, 2024
Author(s):
Shun-Yun Cheng,Jillian Caiazzi,Annabelle Biscans,Julia F Alterman,Dimas Echeverria,Nicholas McHugh,Matthew Hassler,Samson Jolly,Delaney Giguere,Joris Cipi,Anastasia Khvorova,Claudio Punzo
A programmable dual-targeting di-valent siRNA scaffold supports potent multi-gene modulation in the central nervous system
lunes, enero 08, 2024
Author(s):
Jillian Belgrad,Qi Tang,Sam Hildebrand,Ashley Summers,Ellen Sapp,Dimas Echeverria,Dan O'Reilly,Eric Luu,Brianna Bramato,Sarah Allen,David Cooper,Julia Alterman,Ken Yamada,Neil Aronin,Marian DiFiglia,Anastasia Khvorova
Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury
jueves, diciembre 21, 2023
Author(s):
Elif O Dogan,James Bouley,Jianjun Zhong,Ashley L Harkins,Allison M Keeler,Daryl A Bosco,Robert H Brown,Nils Henninger
Glucose stress causes mRNA retention in nuclear Nab2 condensates
martes, diciembre 19, 2023
Author(s):
Stephanie Heinrich,Maria Hondele,Désirée Marchand,Carina Patrizia Derrer,Mostafa Zedan,Alexandra Oswald,Liliana Malinovska,Federico Uliana,Sarah Khawaja,Roberta Mancini,David Grunwald,Karsten Weis
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors
lunes, diciembre 18, 2023
Author(s):
Zexiang Chen,Suet-Yan Kwan,Aamir Mir,Max Hazeltine,Minwook Shin,Shun-Qing Liang,Io Long Chan,Karen Kelly,Krishna S Ghanta,Nicholas Gaston,Yueying Cao,Jun Xie,Guangping Gao,Wen Xue,Erik J Sontheimer,Jonathan K Watts
Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity
miércoles, diciembre 13, 2023
Author(s):
Hassan H Fakih,Qi Tang,Ashley Summers,Minwook Shin,Julianna E Buchwald,Rosemary Gagnon,Vignesh N Hariharan,Dimas Echeverria,David A Cooper,Jonathan K Watts,Anastasia Khvorova,Hanadi F Sleiman
Differences in clamp loader mechanism between bacteria and eukaryotes
lunes, diciembre 11, 2023
Author(s):
Jacob T Landeck,Joshua Pajak,Emily K Norman,Emma L Sedivy,Brian A Kelch
Nano-optogenetic CAR-T Cell Immunotherapy
sábado, diciembre 09, 2023
Author(s):
Nhung Thi Nguyen,Siyao Liu,Gang Han,Yubin Zhou,Kai Huang
Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo
jueves, noviembre 30, 2023
Author(s):
Han Zhang,Karen Kelly,Jonathan Lee,Dimas Echeverria,David Cooper,Rebecca Panwala,Nadia Amrani,Zexiang Chen,Nicholas Gaston,Atish Wagh,Gregory A Newby,Jun Xie,David R Liu,Guangping Gao,Scot A Wolfe,Anastasia Khvorova,Jonathan K Watts,Erik J Sontheimer
Challenges of Assessing Exon 53 Skipping of the Human DMD Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy
lunes, noviembre 27, 2023
Author(s):
Sarah Engelbeen,Daniel O'Reilly,Davy Van De Vijver,Ingrid Verhaart,Maaike van Putten,Vignesh Hariharan,Matthew Hassler,Anastasia Khvorova,Masad J Damha,Annemieke Aartsma-Rus
Quick tips for interpreting cell death experiments
martes, noviembre 21, 2023
Author(s):
Scott J Dixon,Michael J Lee
A nematode model to evaluate microdeletion phenotype expression
lunes, noviembre 13, 2023
Author(s):
Katianna R Antkowiak,Peren Coskun,Sharon T Noronha,Davide Tavella,Francesca Massi,Sean P Ryder
Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin
domingo, noviembre 05, 2023
Author(s):
Qi Tang,Hassan H Fakih,Mohammad Zain Ui Abideen,Samuel R Hildebrand,Khashayar Afshari,Katherine Y Gross,Jacquelyn Sousa,Allison S Maebius,Christina Bartholdy,Pia Pernille Søgaard,Malene Jackerott,Vignesh Hariharan,Ashley Summers,Xueli Fan,Ken Okamura,Kathryn R Monopoli,David A Cooper,Dimas Echeverria,Brianna Bramato,Nicholas McHugh,Raymond C Furgal,Karen Dresser,Sarah J Winter,Annabelle Biscans,Jane Chuprin,Nazgol-Sadat Haddadi,Shany Sherman,Ümmügülsüm Yıldız-Altay,Mehdi Rashighi,Jillian M Richmond,Claire Bouix-Peter,Carine Blanchard,Adam Clauss,Julia F Alterman,Anastasia Khvorova,John E Harris
Awake intracerebroventricular delivery and safety assessment of oligonucleotides in a large animal model
viernes, noviembre 03, 2023
Author(s):
Hector Ribeiro Benatti,Rachel D Prestigiacomo,Toloo Taghian,Rachael Miller,Robert King,Matthew J Gounis,Ugur Celik,Stephanie Bertrand,Susan Tuominen,Lindsey Bierfeldt,Elizabeth Parsley,Jillian Gallagher,Erin F Hall,Abigail W McElroy,Miguel Sena-Esteves,Anastasia Khvorova,Neil Aronin,Heather L Gray-Edwards
Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy
martes, octubre 24, 2023
Author(s):
Ozen Leylek,Megan E Honeywell,Michael J Lee,Michael T Hemann,Gulnihal Ozcan
Surface modification of neurovascular stents: from bench to patient
miércoles, octubre 04, 2023
Author(s):
Christopher T Zoppo,J Mocco,Nathan W Manning,Alexei A Bogdanov,Matthew J Gounis
Protein citrullination: inhibition, identification and insertion
domingo, octubre 01, 2023
Author(s):
Leonard Barasa,Paul R Thompson
A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels
domingo, septiembre 24, 2023
Author(s):
Janneke Doedée Icso,Paul Ryan Thompson
Community-developed checklists for publishing images and image analyses
jueves, septiembre 14, 2023
Author(s):
Christopher Schmied,Michael S Nelson,Sergiy Avilov,Gert-Jan Bakker,Cristina Bertocchi,Johanna Bischof,Ulrike Boehm,Jan Brocher,Mariana T Carvalho,Catalin Chiritescu,Jana Christopher,Beth A Cimini,Eduardo Conde-Sousa,Michael Ebner,Rupert Ecker,Kevin Eliceiri,Julia Fernandez-Rodriguez,Nathalie Gaudreault,Laurent Gelman,David Grunwald,Tingting Gu,Nadia Halidi,Mathias Hammer,Matthew Hartley,Marie Held,Florian Jug,Varun Kapoor,Ayse Aslihan Koksoy,Judith Lacoste,Sylvia Le Dévédec,Sylvie Le Guyader,Penghuan Liu,Gabriel G Martins,Aastha Mathur,Kota Miura,Paula Montero Llopis,Roland Nitschke,Alison North,Adam C Parslow,Alex Payne-Dwyer,Laure Plantard,Rizwan Ali,Britta Schroth-Diez,Lucas Schütz,Ryan T Scott,Arne Seitz,Olaf Selchow,Ved P Sharma,Martin Spitaler,Sathya Srinivasan,Caterina Strambio-De-Castillia,Douglas Taatjes,Christian Tischer,Helena Klara Jambor
Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates
jueves, septiembre 14, 2023
Author(s):
Bin Liu,Xiaolong Dong,Chunwei Zheng,David Keener,Zexiang Chen,Haoyang Cheng,Jonathan K Watts,Wen Xue,Erik J Sontheimer
Development of LB244, an Irreversible STING Antagonist
lunes, septiembre 11, 2023
Author(s):
Leonard Barasa,Sauradip Chaudhuri,Jeffrey Y Zhou,Zhaozhao Jiang,Shruti Choudhary,Robert Madison Green,Elenore Wiggin,Michael Cameron,Fiachra Humphries,Katherine A Fitzgerald,Paul R Thompson
Targeting STING oligomerization with small-molecule inhibitors
lunes, agosto 07, 2023
Author(s):
Fiachra Humphries,Liraz Shmuel-Galia,Zhaozhao Jiang,Jeffrey Y Zhou,Leonard Barasa,Santanu Mondal,Ruth Wilson,Nadia Sultana,Scott A Shaffer,Sze-Ling Ng,G Scott Pesiridis,Paul R Thompson,Katherine A Fitzgerald
Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice
martes, agosto 01, 2023
Author(s):
Aydan Kahriman,James Bouley,Idil Tuncali,Elif O Dogan,Mariana Pereira,Thuyvan Luu,Daryl A Bosco,Samer Jaber,Owen M Peters,Robert H Brown,Nils Henninger
Modulating On-Demand Release of Vancomycin from Implant Coatings via Chemical Modification of a Micrococcal Nuclease-Sensitive Oligonucleotide Linker
lunes, julio 31, 2023
Author(s):
Jordan D Skelly,Feiyang Chen,Shing-Yun Chang,Rewati R Ujjwal,Ananta Ghimire,David C Ayers,Jie Song
Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice
martes, julio 18, 2023
Author(s):
Batuhan Yenilmez,Shauna Harney,Chloe DiMarzio,Mark Kelly,Kyounghee Min,Dimas Echeverria,Brianna M Bramato,Samuel O Jackson,Keith Reddig,Jason K Kim,Anastasia Khvorova,Michael P Czech
Asymmetric trichotomous partitioning overcomes dataset limitations in building machine learning models for predicting siRNA efficacy
lunes, julio 17, 2023
Author(s):
Kathryn R Monopoli,Dmitry Korkin,Anastasia Khvorova
FruitFire: a luciferase based on a fruit fly metabolic enzyme
lunes, julio 10, 2023
Author(s):
Spencer T Adams,Jacqueto Zephyr,Markus F Bohn,Celia A Schiffer,Stephen C Miller
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo
lunes, julio 03, 2023
Author(s):
Vignesh Narayan Hariharan,Jillian Caiazzi,Rachael Miller,Chantal Ferguson,Ellen Sapp,Hassan Fakih,Qi Tang,Nozomi Yamada,Raymond Furgal,Joseph Paquette,Brianna Bramato,Nicholas McHugh,Ashley Summers,Clemens Lochmann,Bruno Godinho,Samuel Hildebrand,Dimas Echeverria,Matthew Hassler,Julia Alterman,Marian DiFiglia,Neil Aronin,Anastasia Khvorova,Ken Yamada
Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease
viernes, junio 30, 2023
Author(s):
Julia M Flynn,Qiu Yu J Huang,Sarah N Zvornicanin,Gila Schneider-Nachum,Ala M Shaqra,Nese Kurt Yilmaz,Stephanie A Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon
Antisense oligonucleotide rescue of CGG expansion-dependent FMR1 mis-splicing in fragile X syndrome restores FMRP
lunes, junio 26, 2023
Author(s):
Sneha Shah,Kevin J Sharp,Sithara Raju Ponny,Jonathan Lee,Jonathan K Watts,Elizabeth Berry-Kravis,Joel D Richter
Firefly luciferin methyl ester illuminates the activity of multiple serine hydrolases
martes, junio 20, 2023
Author(s):
Innus Mohammad,Kate L Liebmann,Stephen C Miller
SARM1, an Enzyme Involved in Axon Degeneration, Catalyzes Multiple Activities through a Ternary Complex Mechanism
lunes, junio 12, 2023
Author(s):
Janneke D Icso,Leonard Barasa,Paul R Thompson
siRNAs-A New Class of Medicines
lunes, junio 12, 2023
Author(s):
Anastasia Khvorova
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo
viernes, junio 09, 2023
Author(s):
Ken Yamada,Vignesh Narayan Hariharan,Jillian Caiazzi,Rachael Miller,Chantal Furguson,Ellen Sapp,Hassan Fakih,Qi Tan,Nozomi Yamada,Raymond C Furgal,Joseph Paquette,Brianna Bramato,Nicholas McHugh,Ashley Summers,Clemens Lochmann,Bruno M D C Godinho,Samuel Hildebrand,Dimas Echeverria,Matthew R Hassler,Julia F Alterman,Marian DiFiglia,Neil Aronin,Anastasia Khvorova
HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues
sábado, mayo 27, 2023
Author(s):
Gordon J Lockbaum,Linah N Rusere,Mina Henes,Klajdi Kosovrasti,Desaboini Nageswara Rao,Ean Spielvogel,Sook-Kyung Lee,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
viernes, mayo 19, 2023
Author(s):
Kyounghee Min,Batuhan Yenilmez,Mark Kelly,Dimas Echeverria,Michael Elleby,Lawrence M Lifshitz,Naideline Raymond,Emmanouela Tsagkaraki,Shauna M Harney,Chloe DiMarzio,Hui Wang,Nicholas McHugh,Brianna Bramato,Brett Morrision,Jeffery D Rothstein,Anastasia Khvorova,Michael P Czech
Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease
sábado, mayo 13, 2023
Author(s):
Daniel O'Reilly,Jillian Belgrad,Chantal Ferguson,Ashley Summers,Ellen Sapp,Cassandra McHugh,Ella Mathews,Adel Boudi,Julianna Buchwald,Socheata Ly,Dimas Moreno,Raymond Furgal,Eric Luu,Zachary Kennedy,Vignesh Hariharan,Kathryn Monopoli,X William Yang,Jeffery Carroll,Marian DiFiglia,Neil Aronin,Anastasia Khvorova
Intravital Imaging of Fluorescent Protein Expression in Mice with a Closed-Skull Traumatic Brain Injury and Cranial Window Using a Two-Photon Microscope
lunes, mayo 08, 2023
Author(s):
Jianjun Zhong,Georgia Gunner,Nils Henninger,Dorothy P Schafer,Daryl A Bosco
Current insights into the role of citrullination in thrombosis
sábado, mayo 06, 2023
Author(s):
R Madison Green,Paul R Thompson
Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope
miércoles, mayo 03, 2023
Author(s):
Nathan Bamidele,Han Zhang,Xiaolong Dong,Nicholas Gaston,Haoyang Cheng,Karen Kelly,Jonathan K Watts,Jun Xie,Guangping Gao,Erik J Sontheimer
Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors
viernes, abril 14, 2023
Author(s):
Samuel R Hildebrand,Adam K Hedger,Ken Yamada,Jonathan K Watts,Anastasia Khvorova
Double Click: Unexpected 1:2 Stoichiometry in a Norbornene-Tetrazine Reaction
viernes, abril 14, 2023
Author(s):
Gitali Devi,Adam K Hedger,Richard J Whitby,Jonathan K Watts
Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo
jueves, marzo 30, 2023
Author(s):
Han Zhang,Karen Kelly,Jonathan Lee,Dimas Echeverria,David Cooper,Rebecca Panwala,Zexiang Chen,Nicholas Gaston,Gregory A Newby,Jun Xie,David R Liu,Guangping Gao,Scot A Wolfe,Anastasia Khvorova,Jonathan K Watts,Erik J Sontheimer
Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses
jueves, marzo 30, 2023
Author(s):
Sarah N Zvornicanin,Ala M Shaqra,Qiuyu J Huang,Elizabeth Ornelas,Mallika Moghe,Mark Knapp,Stephanie Moquin,Dustin Dovala,Celia A Schiffer,Nese Kurt Yilmaz
A thermosensitive PCNA allele underlies an ataxia-telangiectasia-like disorder
miércoles, marzo 29, 2023
Author(s):
Joseph Magrino,Veridiana Munford,Davi Jardim Martins,Thais K Homma,Brendan Page,Christl Gaubitz,Bruna L Freire,Antonio M Lerario,Juliana Brandstetter Vilar,Antonio Amorin,Emília K E Leão,Fernando Kok,Carlos Fm Menck,Alexander Al Jorge,Brian A Kelch
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