Wen Xue, PhD
Research Focus - CRISPR-based Liver Cancer Modeling and Gene Therapy
- Engineering CRISPR-based mouse models of cancer
- Identifying a new tumor suppressor gene network in liver cancer
- Targeting KRAS in lung cancer therapy using small RNA tools
- Developing and optimizing new CRISPR tools for genome editing
- Correcting disease genes in vivo using CRISPR genome editing
Representative Publication
Liu P, Liang S-Q, Zheng C, et al. Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice. Nat Commun. 2021;12(1):2121
In the News
Getting Results…
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Flotte lab to develop gene therapy models for genetic lung disease
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Erik Sontheimer co-leading efforts to develop gene editing toolkit by NIH Somatic Cell Genome Editing Consortium
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MD/PhD-student-led research finds potential new gene target for pediatric liver cancer
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Wen Xue receives $250,000 for pediatric cancer research from Hyundai Hope on Wheels
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CRISPR/Cas9 therapeutic for Tyrosinemia type I delivered to mice
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