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Victor Ambros, PhD

Research Focus - Genetic Control of Developmental Timing in C. elegans

  • Molecular basis of regulated cell fate transitions
  • Regulation of stem cell proliferation and self-renewal
  • Coordination of growth and cell fate across the animal
  • Regulation of mRNA translation by microRNAs and RNA binding proteins

Representative Publication

Nelson C, Ambros V. Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity. Development. 2019;146(5):dev172031.

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In the News

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  • Top story: UMass Chan scientist Victor Ambros wins Nobel Prize

    Top story: UMass Chan scientist Victor Ambros wins Nobel Prize

    Top story: UMass Chan Medical School researcher Victor R. Ambros, PhD, will share the 2024 Nobel Prize in Physiology or Medicine for his co-discovery of microRNA, the very short, single-stranded RNA molecules that are now understood to play a critical role in post-transcriptional gene regulation.

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  • Victor Ambros receives Nobel Prize for discovery of microRNA’s role as conductor of ‘cellular orchestra’

    Victor Ambros receives Nobel Prize for discovery of microRNA’s role as conductor of ‘cellular orchestra’

    Victor R. Ambros, PhD, was awarded the Nobel Prize in Physiology or Medicine on Tuesday, Dec. 10 in Stockholm, Sweden.

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  • Victor Ambros presents 2024 Nobel Lecture: A marvelous unfolding story of microRNAs

    Victor Ambros presents 2024 Nobel Lecture: A marvelous unfolding story of microRNAs

    Victor Ambros, PhD, presents 2024 Nobel Lecture: A marvelous unfolding story of microRNAs.  

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  • UMass Chan to host Nobel Prize ‘watch party’ to celebrate Victor Ambros on Dec. 10

    UMass Chan to host Nobel Prize ‘watch party’ to celebrate Victor Ambros on Dec. 10

    Victor R. Ambros, PhD, will be in Stockholm, Sweden, celebrating Nobel Prize week.

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  • U.S. Embassy of Sweden celebrates Victor Ambros, 2024 Nobel laureates at scientific symposium

    U.S. Embassy of Sweden celebrates Victor Ambros, 2024 Nobel laureates at scientific symposium

    The 2024 Nobel Prize Symposium in Washington, D.C., was hosted by the Embassy of Sweden and the National Academy of Sciences.

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  • UMass leaders share research system success during Medical School visit from ARPA-H director

    UMass leaders share research system success during Medical School visit from ARPA-H director

    UMass Chan and the entire UMass ecosystem are poised for further breakthrough advances in biomedical research, university leaders and congressional delegation members tell ARPA-H director at Medical School visit.  

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  • Podcast: Victor Ambros on team effort behind Nobel Prize winning discovery of microRNA

    Podcast: Victor Ambros on team effort behind Nobel Prize winning discovery of microRNA

    The Conversation Weekly podcast interviewed UMass Chan Nobel Laureate Victor R. Ambros, PhD, to learn more about his role in the discovery of microRNA and what comes next. Dr. Ambros shares the 2024 Nobel Prize in Physiology or Medicine with collaborator Gary B. Ruvkun, PhD, of Massachusetts General Hospital and Harvard Medical School.  

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  • UMass Chan ‘takes pride in calling you one of our own,’ Chancellor tells Nobel-recipient Victor Ambros

    UMass Chan ‘takes pride in calling you one of our own,’ Chancellor tells Nobel-recipient Victor Ambros

    Victor Ambros, PhD, shared his gratitude to his wife and collaborator, Rosalind “Candy” Lee, as well as to the Medical School and scientific community, at a celebration of the Nobel Prize in Physiology or Medicine he co-received with Gary Ruvkun, PhD, professor at Harvard Medical School, for their discovery of microRNA.  

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  • Video: Nobel Laureate Victor Ambros celebrates with UMass Chan community

    Video: Nobel Laureate Victor Ambros celebrates with UMass Chan community

    The UMass Chan Medical School community embraced its newest Nobel Laureate on Monday, Oct. 7, after Victor Ambros, PhD, was named the co-recipient of the 2024 Nobel Prize in Physiology or Medicine for his co-discovery of microRNA. See how the day unfolded in this video.

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  • Victor Ambros’ Nobel Prize win sparks worldwide media attention

    Victor Ambros’ Nobel Prize win sparks worldwide media attention

    Victor R. Ambros, PhD, has garnered international media attention after he was awarded the 2024 Nobel Prize in Physiology or Medicine for his role in the discovery of microRNA.  

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  • Nobel-worthy mentorship: Students rejoice after mentor Victor Ambros wins 2024 Nobel Prize

    Nobel-worthy mentorship: Students rejoice after mentor Victor Ambros wins 2024 Nobel Prize

    Students in the Ambros lab at UMass Chan Medical School and 2006 Nobel Prize winner Craig Mello, PhD, celebrated their mentor, Victor Ambros, PhD, as he received the Nobel Prize in Physiology or Medicine with Gary Ruvkun, PhD, for their discovery of microRNA.  

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  • Champagne toast raised as Nobel winner reacts to news

    Champagne toast raised as Nobel winner reacts to news

    Although Victor Ambros, PhD, was scheduled to move his lab into a new building today, the announcement that he and Gary Ruvkun, PhD, were awarded the Nobel Prize in Physiology or Medicine for their discovery of microRNA, put those plans were put on hold. Read more about how his day unfolded.  

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  • Nobel Laureate Victor Ambros press conference

    Nobel Laureate Victor Ambros press conference

    Watch a video of the UMass Chan Medical School press conference on Monday, Oct. 7, held after the announcement that UMass Chan researcher Victor R. Ambros, PhD, was a co-recipient of the 2024 Nobel Prize in Physiology or Medicine for his discovery of microRNA.

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  • Learn more about Victor Ambros
  • UMass Chan scientist Victor Ambros wins Nobel Prize

    UMass Chan scientist Victor Ambros wins Nobel Prize

    UMass Chan Medical School researcher Victor R. Ambros, PhD, will share the 2024 Nobel Prize in Physiology or Medicine for his co-discovery of microRNA, the very short, single-stranded RNA molecules that are now understood to play a critical role in post-transcriptional gene regulation.  

    Read more
  • UMass Chan study reveals new details about Argonaute syndromes, a recently identified class of neurodevelopmental disorders

    UMass Chan study reveals new details about Argonaute syndromes, a recently identified class of neurodevelopmental disorders

    Researchers have identified amino acid changes in the AGO1 protein that cause Argonaute syndrome. These genetic mutations, studied in the C. elegans model, cause an organism-wide disruption of the RNA silencing process impacting hundreds of different genes.  

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  • UMMS study shows how novel mechanism in P. aeruginosa bacteria disables ribosome

    UMMS study shows how novel mechanism in P. aeruginosa bacteria disables ribosome

    A new study by Alejandro Vasquez-Rifo, PhD, and Victor Ambros, PhD, shows that certain strains of Pseudomonas aeruginosa, a rod-shaped bacterial pathogen that causes disease in plants and animals, including humans, have a unique mechanism for disabling and degrading the ribosome in its host cells.

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  • Victor Ambros named fellow of the American Association for the Advancement of Science

    Victor Ambros named fellow of the American Association for the Advancement of Science

    Victor Ambros, PhD, has been elected by his peers as a fellow of the American Association for the Advancement of Science.

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