Scot A. Wolfe, PhD
Research Focus - Therapeutic Genome Editing Systems
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Application of novel Cas9/Cas12a-based genome editing systems
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Use of therapeutic genome editing for β-hemoglobinopathies and other hematopoietic disorders
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Use of therapeutic genome editing for muscular dystrophies
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Development of delivery approaches for somatic cell genome editing
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Development of artificial zinc finger-based transcriptional regulators
Representative Publication
Iyer S, Suresh S, Guo D, et al. Precise therapeutic gene correction by a simple nuclease-induced double-strand break. Nature. 2019;568(7753):561-565.
In the News
Getting Results…
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UMass Chan scientists receive $2.3 million from Rett Syndrome Research Trust for new research
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Science for Living: Scot Wolfe explains revolutionary CRISPR gene-editing treatment
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Erik Sontheimer co-leading efforts to develop gene editing toolkit by NIH Somatic Cell Genome Editing Consortium
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