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Phillip D. Zamore, PhD

Research Focus - Understanding the Role of Argonaute Proteins in Regulating Gene Expression

  • Explore the diverse functions of Argonaute proteins across the kingdoms of life
  • Elucidate how mammalian piRNAs are produced and function
  • Identify genic and epigenetic features that destine transcripts for processing into piRNAs
  • Study how miRNAs are made and the mechanisms ensuring accurate processing of miRNA precursors
  • Use biochemical principles to predict miRNA regulation of target mRNAs

Representative Publication

Gainetdinov I, Colpan C, Arif A, Cecchini K, Zamore PD. A single mechanism of biogenesis, initiated and directed by PIWI proteins, explains piRNA production in most animals. Mol. Cell. 2018;71(15):775-790.

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In the News

Getting Results…
  • UMass Chan Early Independence Fellows program aims to develop future top investigators

    UMass Chan Early Independence Fellows program aims to develop future top investigators

    Two new donor-funded fellowships are being launched this year at UMass Chan to recruit recent postdoctoral scientists and, through intensive mentoring and resource support, foster their development as independent investigators. The fellowships align with the vision embodied in The Morningside Foundation’s transformational $175 million gift in 2021.  

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  • Phillip Zamore, Roger Davis elected to National Academy of Medicine

    Phillip Zamore, Roger Davis elected to National Academy of Medicine

    UMass Chan Medical School scientists Phillip D. Zamore, PhD, and Roger J. Davis, PhD, FRS, were elected to the National Academy of Medicine on Oct. 9 for their distinguished contributions to medicine and health.

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  • Phillip Zamore elected to National Academy of Sciences

    Phillip Zamore elected to National Academy of Sciences

    Phillip D. Zamore, PhD, is one of 120 newly elected members of the National Academy of Sciences who were recognized for distinguished achievements in original research. Dr. Zamore is credited with identifying the biochemical machinery responsible for RNA silencing.

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  • Katherine Fitzgerald, Phillip Zamore elected to American Academy of Arts & Sciences

    Katherine Fitzgerald, Phillip Zamore elected to American Academy of Arts & Sciences

    Katherine Fitzgerald, PhD, and Phillip D. Zamore, PhD, were elected to the American Academy of Arts & Sciences, which honors excellence and leaders from every field of human endeavor to examine new ideas, address issues of importance to the nation and the world, and work together to cultivate every art and science.

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  • Inside the new mRNA vaccines for COVID-19

    Inside the new mRNA vaccines for COVID-19

    The new vaccines by Pfizer/BioNTech and Moderna use messenger RNA to stimulate the immune system to protect against COVID-19. These vaccines are the first of their kind and researchers at UMass Medical School are among the leading RNA biologists in the world.

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