Michael P. Czech, PhD
Research Focus - Progression from Diabetes and Nonalcoholic Steatohepatitis to Hepatocellular Carcinoma
- Elucidation of the mechanisms underlying the progression from fatty liver disease to fibrosis and cancer
- Characterization of paracrine signaling from hepatocytes to Kupffer and stellate cells
- Study of liver inflammation and its relation to fatty acid synthesis and storage
- Examination of adipocyte metabolism in control of liver function
- Therapeutic development of "self-delivery" RNAi for liver fibrosis and cancer
Representative Publication
Tencerova M, Aouadi M, Vangala P, et al. Activated Kupffer cells inhibit insulin sensitivity in obese mice. FASEB J. 2015;29(7):2959-2969.