Matthew L. Hemming, MD, PhD

Research Focus - Using Basic and Translational Research Tools to Identify Oncogenetic Mechanisms, Biomarkers and Therapies for Sarcoma

• Using broad profiling and functional genomics approaches to understand oncogenic mechanisms in diverse sarcoma subtypes.
• Establishing mechanisms of epigenetic regulation in gastrointestinal stromal tumor (GIST) and their influence on treatment efficacy and clinical outcomes.
• Identifying molecular subtypes and therapeutic vulnerabilities in leiomyosarcoma.
• Characterizing the functions of oncogenic fusion proteins in translocation-associated sarcomas.
• Using insights from mechanistic studies to develop strategies for novel targeted therapies and clinical trials for sarcoma patients.

Representative Publication

Hemming, ML, Benson, MR, Loycano, MA et al. MOZ and Menin-MLL complexes are complementary regulators of chromatin association and transcriptional output in gastrointestinal stromal tumor. Cancer Discovery. 2022; 12(7):1804-1823.

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