Lucio H. Castilla, PhD
Research Focus - Hematopoietic Differentiation and Acute Myeloid Leukemia
- Understand the mechanisms that trigger pre-leukemic and stem and progenitor cell expansion and leukemia development
- Study of pathways altered by core binding factor mutations that regulate oncogenic programs in hematologic malignancies
- Elucidate the processes that drive clonal hematopoiesis in genetics disorders with predisposition to hematologic malignancies
- Development of targeted therapies for acute myeloid leukemia
Representative Publication
Pulikkan JA, Hegde M, Ahmad HM, et al. CBFβ-SMMHC inhibition triggers apoptosis by disrupting MYC chromatin dynamics in acute myeloid leukemia. Cell. 2018;174(1):172-186.