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Gregory J. Pazour, PhD

Research Focus - Assembly Mechanisms and Function of Eukaryotic Cilia

  • Understanding the function of intraflagellar transport proteins in ciliary assembly and ciliary signaling
  • Dissecting the function of cilia in mammalian development and disease
  • Uncovering the role of intraflagellar transport proteins in Hedgehog signaling
  • Elucidating the molecular mechanisms regulating the dynamics of Hedgehog receptors and effectors
  • Exploring new approaches to disrupt Hedgehog signaling for intervention in Hedgehog-driven cancers such as medulloblastoma and basal cell carcinoma

Representative Publication

Desai PB, Stuck MW, Lv B, Pazour GJ. Ubiquitin links Smoothened to intraflagellar transport to regulate Hedgehog signaling J. Cell Biol. 2020;219(7):e201912104.

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  • Gregory Pazour elected fellow of the American Society for Cell Biology

    Gregory Pazour elected fellow of the American Society for Cell Biology

    Gregory J. Pazour, PhD, is one of 16 scientists named a 2019 fellow of the American Society for Cell Biology. An expert in cilia function and assembly, he was the first to draw an unexpected link between cilia dysfunction and polycystic kidney disease.

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