Emma Watson, PhD
Research Focus - Cancer Chromosome Genetics
- Modeling
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Cancer genomes by utilizing forward-and reverse-genetic technologies to generate tumor-like genomes from normal, healthy human cells.
Large-scale chromosomal abnormalities that occur at very high frequencies in tumors, like +1q which occurs in >60% of breast cancers.
Breast, renal, colon, pancreas, and desmoid tumor genomes in the relevant cell types of origin for these cancer types, using the hundreds of cell line resources we generated.
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- Discovering
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How cancer chromosomal abnormalities drive pro-growth phenotypes during tumor genome evolution.
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Representative Publication
Patel RS, Romero R, Watson EV, et al. A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells. Nat Commun. 2022;13(1):256.