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Alkema Lab Publications

Publications from 2024

Veuthey T, Giunti S, De Rosa MJ, Alkema M, Rayes D. The neurohormone tyramine stimulates the secretion of an Insulin-Like Peptide from the intestine to modulate the systemic stress response in C. elegans. bioRxiv. 2024 Feb 09. PMID: 38370834.

Citations:

Kang WK, Florman JT, Araya A, Fox BW, Thackeray A, Schroeder FC, Walhout AJM, Alkema MJ. Vitamin B12 produced by gut bacteria modulates cholinergic signalling. Nat Cell Biol. 2024 Jan; 26(1):72-85. PMID: 38168768.

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Cel

Translation:Animals Cells

Publications from 2023

Belew MY, Huang W, Florman JT, Alkema MJ, Byrne AB. PARP knockdown promotes synapse reformation after axon injury. bioRxiv. 2023 Nov 05. PMID: 37961175.

Citations:

Publications from 2022

Hernandez-Cravero B, Gallino S, Florman J, Vranych C, Diaz P, Elgoyhen AB, Alkema MJ, de Mendoza D. Cannabinoids activate the insulin pathway to modulate mobilization of cholesterol in C. elegans. PLoS Genet. 2022 11; 18(11):e1010346. PMID: 36346800.

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Gen

Translation:Animals

Wirak GS, Florman J, Alkema MJ, Connor CW, Gabel CV. Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance in C. elegans. Elife. 2022 06 15; 11. PMID: 35703498.

Citations: 7

Fields:

Bio

Translation:Animals Cells

Florman JT, Alkema MJ. Co-transmission of neuropeptides and monoamines choreograph the C. elegans escape response. PLoS Genet. 2022 Mar 03; 18(3):e1010091. PMID: 35239681.

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Gen

Publications from 2021

Ramachandran S, Banerjee N, Bhattacharya R, Lemons ML, Florman J, Lambert CM, Touroutine D, Alexander K, Schoofs L, Alkema MJ, Beets I, Francis MM. A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior. Elife. 2021 11 12; 10. PMID: 34766905.

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Fields:

Bio

Translation:Animals

Reilly DK, McGlame EJ, Vandewyer E, Robidoux AN, Muirhead CS, Northcott HT, Joyce W, Alkema MJ, Gegear RJ, Beets I, Srinivasan J. Distinct neuropeptide-receptor modules regulate a sex-specific behavioral response to a pheromone. Commun Biol. 2021 08 31; 4(1):1018. PMID: 34465863.

Citations:

Maicas M, Jimeno-Martín Á, Millán-Trejo A, Alkema MJ, Flames N. The transcription factor LAG-1/CSL plays a Notch-independent role in controlling terminal differentiation, fate maintenance, and plasticity of serotonergic chemosensory neurons. PLoS Biol. 2021 07; 19(7):e3001334. PMID: 34232959.

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Fields:

Bio

Translation:Animals Cells

Ji N, Venkatachalam V, Rodgers HD, Hung W, Kawano T, Clark CM, Lim M, Alkema MJ, Zhen M, Samuel AD. Corollary discharge promotes a sustained motor state in a neural circuit for navigation. Elife. 2021 04 21; 10. PMID: 33880993.

Citations: 1

Fields:

Bio

Translation:Animals Cells

Publications from 2020

Wang Y, Zhang X, Xin Q, Hung W, Florman J, Huo J, Xu T, Xie Y, Alkema MJ, Zhen M, Wen Q. Flexible motor sequence generation during stereotyped escape responses. Elife. 2020 06 05; 9. PMID: 32501216.

Citations: 7

Fields:

Bio

Translation:Animals Cells

Romanelli-Credrez L, Doitsidou M, Alkema MJ, Salinas G. HIF-1 Has a Central Role in Caenorhabditis elegans Organismal Response to Selenium. Front Genet. 2020; 11:63. PMID: 32161616.

Citations:

Publications from 2019

De Rosa MJ, Veuthey T, Florman J, Grant J, Blanco MG, Andersen N, Donnelly J, Rayes D, Alkema MJ. The flight response impairs cytoprotective mechanisms by activating the insulin pathway. Nature. 2019 Aug 28. PMID: 31462774.

View in: PubMed

Huang YC, Pirri JK, Rayes D, Gao S, Mulcahy B, Grant J, Saheki Y, Francis MM, Zhen M, Alkema MJ. Gain-of-function mutations in the UNC-2/CaV2a channel lead to excitation-dominant synaptic transmission in C. elegans. Elife. 2019 Jul 31; 8. PMID: 31364988.

View in: PubMed

Chute CD, DiLoreto EM, Zhang YK, Reilly DK, Rayes D, Coyle VL, Choi HJ, Alkema MJ, Schroeder FC, Srinivasan J. Co-option of neurotransmitter signaling for inter-organismal communication in C. elegans. Nat Commun. 2019 Jul 18; 10(1):3186. PMID: 31320626.

View in: PubMed

Diapause induces functional axonal regeneration after necrotic insult in C. elegans, Mauricio Caneo, Victoria Julian, Alexandra B. Byrne, Mark J. Alkema, and Andrea Calixto PDF

Co-option of neurotransmitter signaling for inter-organismal communication in C. elegans, Christopher D. Chute, Elizabeth M. DiLoreto, Ying K. Zhang, Douglas K. Reilly, Diego Rayes, Veronica L. Coyle, Hee June Choi, Mark J. Alkema, Frank C. Schroeder, and Jagan Srinivasan PDF

Gain-of-function mutations in the UNC-2/CaV2alpha channel lead to excitation-dominant synaptic transmission in C. elegans, Yung-Chi Huang, Jennifer K. Pirri, Diego Rayes, Shangbang Gao, Ben Mulcahy, Jeff Grant, Yasunori Saheki, Michael M. Francis, Mei Zhen, and Mark J. Alkema PDF

Publications from 2018

Excitatory motor neurons are local oscillators for backward locomotion, Shangbang Gao, Sihui Asuka Guan, Anthony D. Fouad, Jun Meng, Taizo Kawano, Yung-Chi Huang, Yi Li, Salvador Alcaire, Wesley Hung, Yangning Lu, Yingchuan Billy Qi, Yishi Jin, Mark J. Alkema, Christopher Fang-Yen, and Mei Zhen PDF

Neurexin directs partner-specific synaptic connectivity in C. elegans, Alison Philbrook, Shankar Ramachandran, Christopher M. Lambert, Devyn Oliver, Jeremy Florman, Mark J. Alkema, Michele Lemons, and Michael M. Francis PDF

Publications from 2017

Excitatory Motor Neurons are Local Central Pattern Generators in an Anatomically Compressed Motor Circuit for Reverse Locomotion, Shangbang Gao, Sihui Asuka Guan, Anthony D. Fouad, Jun Meng, Yung-Chi Huang, Yi Li, Salvador Alcaire, Wesley Hung, Taizo Kawano, Yangning Lu, Yingchuan Billy Qi, Yishi Jin, Mark J. Alkema, Christopher Fang-Yen, and Mei Zhen PDF

Behavioral and Functional Analysis of a Calcium Channelopathy in Caenorhaditis elegans, Yung-Chi Huang PDF

Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans, Laura Romanelli-Cedrez, Ines Carrera, Lucia Otero, Antonio Miranda-Vizuete, Marco Mariotti, Mark J. Alkema, and Gustavo Salinas Link

Publications from 2016

The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length, Daniel E. Cook, Stefan Zdraljevic, Robyn E. Tanny, Beomseok Seo, David D. Riccardi, Luke M. Noble, Matthew V. Rockman, Mark J. Alkema, Christian Braendle, Jan E. Kammenga, John Wang, Leonid Kruglyak, Marie-Anne Felix, Junho Lee, and Erik C. Andersen PDF

The genetic basis of natural variation in C. elegans telomere length, Daniel E. Cook, Stefan Zdraljevic, Robyn E. Tanny, Beomseok Seo, David Riccardi, Luke M. Noble, Matthew V. Rockman, Mark J. Alkema, Christian Braendle, Jan Kammenga, John Wang, Leonid Kruglyak, Marie-Anne Felix, Junho Lee, and Erik Andersen PDF

Imprinting: When Early Life Memories Make Food Smell Bad, Diego Rayes and Mark J. Alkema Link

Pan-neuronal imaging in roaming Caenorhabditis elegans, Vivek Venkatachalam, Ni Ji, Xian Wang, Christopher M. Clark, James Kameron Mitchell, Mason Klein, Christopher J. Tabone, Jeremy Florman, Hongfei Ji, Joel Greenwood, Andrew D. Chisholm, Jagan Srinivasan, Mark J. Alkema, Mei Zhen, and Aravinthan D.T. Samuel PDF

Publications from 2015

The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion, Shangbang Gao, Lin Xie, Taizo Kawano, Michelle D. Po, Sihui Guan, Mei Zhen, Jennifer K. Pirri, and Mark J. Alkema Link

Caenorhabditis elegans exhibit a coupling between the defecation motor program and directed locomotion, Stanislav Nagy, Yung-Chi Huang, Mark J. Alkema, and David Biron PDF

Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels, Kelly H. Oh, Linu S. Abraham, Chandler Gegg, Christian Silvestri, Yung-Chi Huang, Mark J. Alkema, Jacob Furst, Daniela Raicu, and Hongkyun Kim PDF

A Change in the Ion Selectivity of Ligand-Gated Ion Channels Provides a Mechanism to Switch Behavior, Jennifer K. Pirri, Diego Rayes, and Mark J. Alkema PDF

Publications from 2014

A conserved dopamine-cholecystokinin signaling pathway shapes context-dependent Caenorhabditis elegans behavior, Raja Bhattacharya, Denis Touroutine, Belinda Barbagallo, Jason Climer, Christopher M. Lambert, Christopher M. Clark, Mark J. Alkema, and Michael M. Francis PDF

Neural Orchestration of the C. elegans Escape Response: A Dissertation, Christopher M. Clark PDF

Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans, Frederick B. Shipley, Christopher M. Clark, Mark J. Alkema, and Andrew M. Leifer PDF

Neuronal regeneration in C. elegans requires subcellular calcium release by ryanodine receptor channels and can be enhanced by optogenetic stimulation, Lin Sun, James Shay, Melissa McLoed, Kevin Roodhouse, Samuel H. Chung, Christopher M. Clark, Jennifer K. Pirri, Mark J. Alkema, and Christopher V. Gabel Link

Publications from 2013

Monoaminergic orchestration of motor programs in a complex C. elegans behavior, Jamie L. Donnelly, Christopher M. Clark, Andrew M. Leifer, Jennifer K. Pirri, Marian Haburcak, Michael M. Francis, Aravinthan D. T. Samuel, and Mark J. Alkema PDF

Anatomical basis of sun compass navigation II: The neuronal composition of the central complex of the monarch butterfly, Stanley Heinze, Jeremy Florman, Surainder Asokaraj, Basil el Jundi, and Steven M. Reppert Link

Identification of distinct tyraminergic and octopaminergic neurons innervating the central complex of the desert locust, Schistocerca gregaria, Uwe Homberg, Jutta Seyfarth, Ulrike Binkle, Maria Monastirioti, and Mark J. Alkema Link

The Role of Ion Channels in Coordinating Neural Circuit Activity in Caenorhabditis elegans: A Dissertation, Jennifer K. Pirri PDF

Publications from 2012

The neuroethology of C. elegans escape, Jennifer K. Pirri and Mark J. Alkema Link

Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans, Jennifer A. Schumacher, Yi-Wen Hsieh, Shiuhwei Chen, Jennifer K. Pirri, Mark J. Alkema, Wen-hong Li, Chieh Chang, and Chiou-Fen Chuang PDF

Publications from 2011

Tyraminergic G Protein-Coupled Receptors Modulate Locomotion and Navigational Behavior In C. Elegans: A Dissertation, Jamie L. Donnelly PDF

Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling, Alex C. Koon, James A. Ashley, Romina Barria, Shamik DasGupta, Ruth Brain, Scott Waddell, Mark J. Alkema, and Vivian Budnik Link

Optogenetic manipulation of neural activity in freely moving Caenorhabditis elegans, Andrew M. Leifer, Christopher Fang-Yen, Marc Gershow, Mark J. Alkema, and Aravinthan D. T. Samuel Link

The C. elegans Touch Response Facilitates Escape From Predacious Fungi, Sean M. Maguire, Christopher M. Clark, Jennifer K. Pirri, John J. Nunnari, and Mark J. Alkema Link

Publications from 2009

Oxygen sensation: into thick air, Mark J. Alkema Link

A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors, Christian A. Grove, Federico De Masi, M. Inmaculada Barrasa, Daniel E. Newburger, Mark J. Alkema, Martha L. Bulyk, and Albertha J. M. Walhout Link

A Tyramine-Gated Chloride Channel Coordinates Distinct Motor Programs of a Caenorhabditis elegans Escape Response, Jennifer K. Pirri, Adam D. McPherson, Jamie L. Donnelly, Michael M. Francis, and Mark J. Alkema Link