Vascular and Endovascular Surgery Society Award to Investigate Diabetic Wound Healing in the Nguyen Lab
Date Posted: Tuesday, January 26, 2021
Tammy T. Nguyen, MD, PhD, is analyzing bone marrow to learn why people with diabetes have a difficult time healing diabetic foot wounds.
“When you have a skin breakdown, your immune cells come in and they help clear out the infection and build a tissue base that allows for new tissues to grow and heal your wound,” said Dr. Nguyen, assistant professor of surgery at UMass Chan Medical School and Medical Director of the Lower Extremity Wound Clinic at UMass Memorial Medical Center. “I know that healing stems from immune cells, so my question is, does a person living with diabetes have an immune system that makes them maladaptive to wound healing?”
Dr. Nguyen received a $22,500 grant to explore this question. The Vascular and Endovascular Surgery Society’s 2021 Early Career Faculty Research Award is designed to help new vascular surgical investigators initiate projects that will lead to additional funding.
“I want to understand why patients with diabetes have a hard time healing their foot wounds. I see these patients in vascular surgery because a lot of them have blood vessel disease that inhibit them from healing. However, even if you fix their blood vessel disease, sometimes they still have a hard time healing, suggestive of their underlying diabetes,” added Dr. Nguyen. “People with diabetes in general are known to be poor wound healers. It doesn’t matter if it’s the foot or you operate on the belly - anywhere - they just don’t heal very well. We don’t really know why.”
She is comparing immune cells from people with diabetes who have had amputations as well as nondiabetic patients who have had amputations for other reasons.
Dr. Nguyen joined UMass Chan Medical School as a faculty member after completing her residency at UMass Memorial. The Southern California native is an MD/PhD graduate of the University of Utah School of Medicine. Her PhD is in biochemistry.
She has combined her interests in vascular surgery and homeless medicine by helping to organize health fairs for the homeless in Worcester. On World Diabetes Day, November 14 2020, Dr. Nguyen and colleagues provided foot screenings at a Worcester homeless shelter while UMass Memorial Diabetes Center of Excellence care team members did check ups and distributed rfesources & supplies. The event has grown into a bi-annual diabetes foot & health clinic for the underserved community held every Fall and Spring.
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