Professor, Program in Molecular Medicine, Co-Director, UMass Chan Diabetes Center of Excellence, The Herman G. Berkman Chair in Diabetes Care Innovation

Reconstructing human Type 1 diabetes in novel "humanized" mice as preclinical models investigating cells and tissues derived from T1D patients 

Testing genetically modified stem cell-derived insulin-producing islets to protect them from autoimmune attack

The William and Doris Krupp Professor of Medicine, Co-Director, UMass Chan Diabetes Center of Excellence, Director, Breakthrough T1D Center of Excellence in New England

Exploring beta cell biology and anti-beta cell immune responses underlying Type 1 diabetes

Developing innovative techniques to sort human pancreatic islet cell subsets from donors with both Type 1 and Type 2 diabetes to determine the transcriptome from those purified cells

Assistant Professor, Program in Molecular Medicine, Investigator, Breakthrough T1D Center of Excellence in New England

Studying the influence of molecular metabolism on cell function and fate in pancreatic beta cells and local immune cells in health, obesity and diabetes. We identified metabolic pathways that protect against inflammation associated with metabolic disease.

Now we're looking at how these pathways shape the metabolic milieu of pancreatic islets and local immune cell activities using metabolomics, proteomics and transcriptomics.

Associate Professor, Program in Molecular Medicine, The Harvey A. Shultz Chair in Diabetes, Associate Director, UMass Chan Diabetes Center of Excellence, Co-Director, UMass Humanized Mouse Core, 

Developing novel "humanized" mouse models to observe and identify immune mechanisms that regulate Type 1 diabetes development

Investigating interactions between human pancreatic beta cells and immune cells from individuals with T1D in vivo to understand the etiology and pathogenesis of the autoimmune attack 

Professor, Program in Molecular Medicine, Endowed Chair in Diabetes Research, Director, Clinical Translational Research Pathway, T.H. Chan School of Medicine

Professor, Program in Molecular Medicine, The Isadore and Fannie Foxman Chair of Medical Research

Investigating molecular mechanisms whereby insulin signaling regulates energy homeostasis

Gene editing & deletion to enhance insulin signaling/energy expenditure in Type 2 diabetes & obesity

Techniques include RNAi screens, digital imaging, TIRF microscopy, gene knockouts and analysis of human adipose tissues

Chair, Program in Molecular Medicine, H. Arthur Smith Chair in Biomedical Research, Howard Hughes Medical Institute Investigator

Investigating molecular mechanisms by which inflammation contributes to Type 2 diabetes, cancer & stroke

Our studies of stress signaling pathways have led to the discovery of new genes that contribute to the development of T2D and other metabolic diseases

Professor, Program in Molecular Medicine

Investigating insulin resistance development in obesity and lipodystrophy

Identifying therapeutic strategies to improve how the body processes blood glucose

Exploring biochemical mechanisms controlling cell growth and metabolism and their significance to the pathogenesis of Type 2 diabetes

Associate Professor, Department of Medicine, The George F. and Sybil H. Fuller Term Chair in Diabetes, Investigator, Breakthrough T1D Center of Excellence in New England

Professor of Molecular Medicine, Director, Metabolic Disease Research Center 

Associate Professor, Program in Molecular Medicine

Professor and Vice Chair, Department of Surgery, The Johnnie Ray Cox Term Chair in Biomedical Research

Investigating new hematopoietic stem cell–based therapeutic approaches to treat people with Type 2 diabetes and other common diseases

Determining the effects of T2D on wound healing and identifying the molecular & cellular mechanisms that could lead to potential therapies

Professor of Pediatrics, Psychiatry and Population & Quantitative Health Sciences, Chair and Professor, Department of Obstetrics and Gynecology, Founding Director, Ob/Gyn Research Division

Interested in the role that adipose tissue plays in gestational diabetes, as well as angiogenic biomarkers and gestational weight gain

Assistant Professor of Surgery, Division of Vascular and Endovascular Surgery, Medical Director, Lower Extremity Wound Clinic, UMass Memorial Medical Center

Professor of Medicine, Division of Infectious Diseases and Immunology, Investigator, Breakthrough T1D Center of Excellence in New England