Michael Brodsky, PhD
Research Focus - Using Gene Editing to Model and Target Huntington’s Disease and Other Human Disease
- Creation of new human disease models with the Mutagenesis Core Facility
- Manipulating DNA repair pathways to improve gene editing approaches to correct trinucleotide repeat expansion diseases
- Allele-specific gene editing of the mutant Huntington’s Disease gene
Representative Publication
Borel F, Sun H, Zeiger M, et al. Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema. Proc Natl Acad Sci USA. 2018;115(11):2788-2793.